Prescription onlyLower-cost generic available

Neurontin Alternatives

(Gabapentin)

  • Pill
  • Oral solution
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Compare Neurontin (Gabapentin) to alternatives

These medications are comparable to Neurontin (Gabapentin) or used for similar purposes.

Neurontin
(Gabapentin)

Cymbalta
(Duloxetine)

Lyrica
(Pregabalin)

Depacon
(Valproate, Valproic Acid, Or Divalproex)

Elavil
(Amitriptyline)

Norpramin
(Desipramine)

Pamelor
(Nortriptyline)

Lidoderm
(Lidocaine)

Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Treats nerve pain and prevents seizures. Lyrica (Pregabalin) works well as an add-on medicine for seizures and fibromyalgia, but it's especially effective for nerve-related pain after shingles. Not available as a generic, so it might be expensive.Prevents seizures and stabilizes mood. Depacon (Valproate, Valproic Acid, Or Divalproex) is good long-term prevention for epilepsy, bipolar disorder, and migraines, but can cause weight gain.Improves mood and relieves certain kinds of pain. Elavil (Amitriptyline) is an older antidepressant that's sometimes used to treat pain and sleep problems, but it can have more side effects than similar medications.Coming soon.Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Treats nerve pain. Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.542087542087542Neurontin
Reviews for Neurontin (Gabapentin)
57%
of people say Neurontin (Gabapentin) is worth it
39%
say it works well
19%
say it's a big hassle
Reviews for Cymbalta (Duloxetine)
59%
+2% vs. Neurontin (Gabapentin)
49%
+10% vs. Neurontin (Gabapentin)
24%
5% vs. Neurontin (Gabapentin)
Reviews for Lyrica (Pregabalin)
46%
11% vs. Neurontin (Gabapentin)
41%
+2% vs. Neurontin (Gabapentin)
32%
13% vs. Neurontin (Gabapentin)
Reviews for Depacon (Valproate, Valproic Acid, Or Divalproex)
46%
11% vs. Neurontin (Gabapentin)
39%
Same vs. Neurontin (Gabapentin)
27%
8% vs. Neurontin (Gabapentin)
Reviews for Elavil (Amitriptyline)
52%
5% vs. Neurontin (Gabapentin)
34%
5% vs. Neurontin (Gabapentin)
23%
4% vs. Neurontin (Gabapentin)

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Side effects
NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
  • Dizziness 21%
  • Drowsiness 16%
  • Lack of muscle coordination 7%
  • Leg or ankle swelling 6%
  • Fatigue 6%
  • Hostility 5%
  • Involuntary eye movement 4%
  • Double vision 4%
  • Tremor 4%
  • Dry mouth 4%
More Neurontin side effects »
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%
  • Constipation 7%
  • Somnolencee 7%
  • Decreased appetite 7%
  • Fatigued 6%
  • Sleep difficulty 5%
  • Dizziness 4%
  • Fatigue 4%
More Cymbalta side effects »
  • Dizziness 36%
  • Nerve damage 34%
  • Drowsiness 24%
  • Lack of muscle coordination 24%
  • Weight gain 15%
  • Constipation 13%
  • Weight increased 12%
  • Dry mouth 12%
  • Leg or ankle swelling 12%
  • Vision blurred 11%
More Lyrica side effects »
  • Nausea 34%
  • Muscle weakness 20%
  • Vomiting 20%
  • Abdominal pain 17%
  • Dizziness 12%
  • Headache 10%
  • Double vision 7%
  • Involuntary eye movement 7%
  • Lack of muscle coordination 7%
  • Accidental injury 6%
More Depakote side effects »

The Elavil FDA package insert doesn’t have numbers about how common side effects are.

More about Elavil side effects »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »

The Lidocaine FDA package insert doesn’t have numbers about how common side effects are.

More about Lidocaine side effects »
How it works
NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Lyrica (Pregabalin) is a nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.Depacon (Valproate, Valproic Acid, Or Divalproex) is an antiepileptic. Researchers don't know exactly how it works. It seems to increase the amount of GABA, a chemical that calms nerves in the brain.Elavil (Amitriptyline) is a tricyclic antidepressant (TCA). Researchers don't know exactly how it works. It may change serotonin and norepinephrine activity in the brain, which regulates mood and pain perception. It also has sedative effects.Coming soon.Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Lidoderm (Lidocaine) is a local anesthetic. It absorbs into your skin where it targets damaged nerves and relieves burning pain.
Type of medication
NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
Anticonvulsant
GABA analog
Prescription only
Antidepressant
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Anticonvulsant
GABA analog
Prescription only
AnticonvulsantPrescription only
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Coming soon.
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Local anestheticPrescription only
Available as
NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
  • Pill
  • Oral solution
  • Extended release
  • Pill
  • Liquid
  • Pill
  • Extended release
  • Extended release capsule
  • Sprinkle
  • Liquid
  • Pill
  • Pill
  • Pill
  • Liquid
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Used for (click to learn more)
NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
  • Depression
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Neurontin (Gabapentin)

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lyrica (Pregabalin)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Depacon (Valproate, Valproic Acid, Or Divalproex)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Elavil (Amitriptyline)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Norpramin (Desipramine)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Pamelor (Nortriptyline)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Lidoderm (Lidocaine)
Risk factors for serious side effects
NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
      Pregnancy category
      NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      DFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      NFDA pregnancy category (Unknown)

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      See the FDA package insert
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      Alcohol
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      No specific alcohol-related info.
      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
      No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
      Food
      • Take the extended-release tablet with food.
      • Take with food to avoid upset stomach.
      No specific food-related info.
      • Take with food to avoid upset stomach.
      No specific food-related info.No specific food-related info.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
      Sleep
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      No specific sleep-related info.
      • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
      • Can make you drowsy or dizzy.
      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
      No specific sleep-related info.
      • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
      • Can cause dizziness, drowsiness, constipation, and weight gain.
      No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
      Weight
      No specific weight-related info.No specific weight-related info.No specific weight-related info.
      • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
      • May cause hair loss and weight gain.
      • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
      • Can cause dizziness, drowsiness, constipation, and weight gain.
      No specific weight-related info.No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
      • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
      • It's available as a generic, so it's less expensive than similar medications.
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates for depression.
      • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      • Relieves nerve-related (neuropathic) pain caused by different conditions including diabetes, shingles (herpes zoster), fibromyalgia, and spinal cord damage.
      • Studies show that lower doses of Lyrica (Pregabalin) cause fewer side effects and still relieve pain just as well as higher doses.
      • Also used in combination with other medications to treat epilepsy (partial seizures).
      • Lowers the frequency of seizures, especially for people with absence, tonic-clonic, and complex partial seizures.
      • One of the first-line options to stabilize mood for people with bipolar disorder.
      • Helpful in preventing frequent migraine headaches.
      • Low doses work well to treat certain kinds of chronic pain. It can take 2 weeks to feel the full effects of the medication.
      • Low doses of Elavil (Amitriptyline) start working in 45 minutes to help you sleep better.
      • Six out of every ten people who use an antidepressant for the first time find that it works for them.
      Coming soon.
      • Helpful with treating certain types of pain, like migraines or nerve-related pain.
      • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
      • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
      • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
      • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
      Downsides and risks
      NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
      • Not the best option for people with high blood pressure.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      • Not available as a generic, so it can be pricey.
      • You can't skip or miss doses since suddenly stopping Lyrica (Pregabalin) can cause seizures.
      • Lyrica (Pregabalin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, and confusion.
      • Has a higher risk than other pain medicines of affecting your heart rate or rhythm, so it might not be the best choice if you have cardiovascular disease (previous heart attack, stroke, fast/uncontrolled heart rate, or irregular heartbeat).
      • Can cause upset stomach, hair loss, weight gain, sleepiness, and tremor.
      • Can cause liver damage, so it's probably not safe if you already have liver problems.
      • Not safe to use if you're pregnant.
      • Requires routine blood tests to see how the medicine is affecting your body.
      • When used for depression, Elavil (Amitriptyline) causes more side effects and has a higher risk of overdose than other antidepressants. It's usually used when other medications haven't worked.
      • It's more likely to cause sleepiness, nausea, constipation, diarrhea, and weight gain (1 to 5 pounds) than other antidepressants.
      • People age 65 and older have a higher risk for this medication's side effects.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Coming soon.
      • Side effects are usually manageable, but can be annoying.
      • Increases the risk of falls, especially when used in the elderly.
      • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
      • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
      • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
      • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
      • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
      • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
      Tips from our pharmacists for people taking the medication
      NeurontinCymbaltaLyricaDepakoteElavilNorpraminPamelorLidocaine
      • Side effects are common, but usually manageable.
      • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
      • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
      • Take the extended-release tablet with food.
      • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
      • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Take with food to avoid upset stomach.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Some people feel relief from pain in a week.
      • Can make you drowsy or dizzy.
      • Don't stop taking it suddenly without talking to your doctor. You'll need to slowly lower your dose over at least a week to avoid withdrawal symptoms.
      • Tell your doctor if you have unexplained confusion or changes in your thoughts or behavior.
      • It's not safe to take this medication with alcohol or other drugs that make you drowsy.
      • For the first week, avoid activities that require you to be alert.
      • Don't use if pregnant.
      • Requires routine blood tests.
      • May cause hair loss and weight gain.
      • Different versions of Depakote have different dosing. Be careful.
      • Report confusion, persistent abdominal pain, yellowing of eyes/skin, or easy bruising to your doctor.
      • Takes 3 to 4 weeks to feel full effects on mood.
      • Take with food to avoid upset stomach.
      • Take at bedtime to avoid some of its side effects.
      • Can cause dizziness, drowsiness, constipation, and weight gain.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Coming soon.
      • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
      • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Starts working with the first dose, but full effects can take longer.
      • Remove the protective lining on the patch before applying the patch to unbroken skin.
      • Leave the patch on for up to 12 hours during a 24 hour period.
      • You can cut the patches to create a custom fit for the area of skin you need to apply it to.
      • Don't place any tight wraps or heating pads over the patch while it's on.
      • Make sure not to touch your eyes after touching the patch. Always wash your hands after putting it on or taking it off.
      Learn more
      More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
      More about CymbaltaSide effectsReviews & ratingsFDA package insert
      More about LyricaSide effectsReviews & ratingsFDA package insert
      More about DepakoteSide effectsReviews & ratingsFDA package insert
      More about ElavilSide effectsReviews & ratingsFDA package insert
      More about NorpraminSide effectsReviews & ratingsFDA package insert
      More about PamelorSide effectsReviews & ratingsFDA package insert
      More about LidocaineSide effectsReviews & ratingsFDA package insert