Prescription onlyLower-cost generic available

Macrobid Alternatives

(Nitrofurantoin)

Back to: Full Site Navigation

Compare Macrobid (Nitrofurantoin) to alternatives

These medications are comparable to Macrobid (Nitrofurantoin) or used for similar purposes.

Macrobid
(Nitrofurantoin)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Augmentin
(Amoxicillin / Clavulanate)

Cetraxal
(Ciprofloxacin)

Treats urinary tract infections. Macrobid (Nitrofurantoin) works best in young, otherwise healthy females. It shouldn't be used by children, the elderly, or people with kidney problems.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.Kills bacteria. Augmentin (Amoxicillin / Clavulanate) is good for treating many bacterial infections and is available as generic. However, it will make birth control pills less effective. It also has to be taken with food since it can cause an upset stomach.Treats ear infections. Cetraxal (Ciprofloxacin) is an easy to use antibiotic that treats most ear infections.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Loading pricing data...
Loading pricing data...
Loading pricing data...
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
4% vs. Macrobid (Nitrofurantoin)
50%
Same vs. Macrobid (Nitrofurantoin)
22%
9% vs. Macrobid (Nitrofurantoin)
Reviews for Augmentin (Amoxicillin / Clavulanate)
68%
+5% vs. Macrobid (Nitrofurantoin)
52%
+2% vs. Macrobid (Nitrofurantoin)
13%
Same vs. Macrobid (Nitrofurantoin)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
NitrofurantoinBactrimAugmentinCetraxal

The Nitrofurantoin FDA package insert doesn’t have numbers about how common side effects are.

More about Nitrofurantoin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »

The Augmentin FDA package insert doesn’t have numbers about how common side effects are.

More about Augmentin side effects »

The Cetraxal FDA package insert doesn’t have numbers about how common side effects are.

More about Cetraxal side effects »
How it works
NitrofurantoinBactrimAugmentinCetraxal
Macrobid (Nitrofurantoin) is an antibiotic. It's used to treat urinary tract infections by killing bacteria in the urine.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.Augmentin (Amoxicillin / Clavulanate) is a combination antibiotic. Amoxicillin kills bacteria and prevents them from reproducing and making their own protective covering. Clavulanate stops chemicals the bacteria make to resist antibiotics.Cetraxal (Ciprofloxacin) is an antibiotic that stops bacteria from being able to grow and replicate. Preventing bacteria from working prevents the infection from continuing.
Type of medication
NitrofurantoinBactrimAugmentinCetraxal
AntibioticPrescription only
Antibiotic
Sulfonamide
Prescription only
Antibiotic
Penicillin
Prescription only
Antibiotic
Quinolone
Prescription only
Available as
NitrofurantoinBactrimAugmentinCetraxal
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
  • Chewable tablet
  • Extended release
  • Liquid
  • Ear drops
Used for (click to learn more)
NitrofurantoinBactrimAugmentinCetraxal
Risk factors for serious side effects
NitrofurantoinBactrimAugmentinCetraxal
  • Pregnant women
  • Newborn babies
  • History of kidney disease
  • History of liver disease
  • Long antibiotic treatment period
Detailed Macrobid (Nitrofurantoin) risks & warnings »
Coming soon.Coming soon.Coming soon.
Pregnancy category
NitrofurantoinBactrimAugmentinCetraxal
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
DFDA pregnancy category (Weigh risks vs. benefits)

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
  • Take it with food (ideally breakfast and dinner) to prevent side effects and improve the drug's absorption.
No specific food-related info.
  • Should be taken with food since it can cause stomach upset.
  • Take each dose with a meal since it may cause an upset stomach.
No specific food-related info.
Kidneys and liver
  • Can't be used if you have kidney problems or don't urinate often (the medication could build up and cause toxicity).
  • Macrobid (Nitrofurantoin) can cause significant kidney problems. Don't take it if you haven't been urinating often enough or have a history of kidney problems.
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
NitrofurantoinBactrimAugmentinCetraxal
  • Macrobid (Nitrofurantoin) works well to treat urinary tract infections.
  • Young and otherwise healthy females have the best results when taking Macrobid (Nitrofurantoin).
  • It's not too common, but you can get a test done that'll show if Macrobid (Nitrofurantoin) will work for you.
  • Available in different forms: tablet, capsule and suspension.
  • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
  • Available in generic.
  • Used to treat many types of bacterial infections.
  • Available in different forms: tablet, capsule, and suspension.
  • Less resistance seen in bacteria to this antibiotic. Your doctor may run tests to see which antibiotics will kill the bacteria causing your infection.
  • Available in generic.
  • Used to treat many types of bacterial infections.
  • Cetraxal (Ciprofloxacin) is an effective antibiotic to treat bacteria that typically grow in the ear.
  • Cetraxal (Ciprofloxacin) is easy to use and it's okay even if there's a small amount of liquid left in the vial after giving yourself the dose.
  • Usually only given twice a day.
Downsides and risks
NitrofurantoinBactrimAugmentinCetraxal
  • Shouldn't be used for a long period of time.
  • Can't be used in children under 12 years old.
  • Interacts with drugs like probenecid and sulfinpyrazone.
  • Can't be used if you have kidney problems or don't urinate often (the medication could build up and cause toxicity).
  • Makes your skin more sensitive to the sun.
  • Has to be taken with plenty of liquids.
  • May cause birth defects.
  • Can cause diarrhea.
  • If you're on birth control pills, you should use a barrier method (condoms, diaphragms) since Augmentin can make them less effective.
  • Should be taken with food since it can cause stomach upset.
  • If you have phenylketonuria (PKU), talk to your doctor to prescribe an alternative.
  • Cetraxal (Ciprofloxacin) is not available generically, so it may be a bit pricey.
  • Can cause ear pain, itching, or a headache.
  • Discontinue use immediately if a rash develops on or in your ear.
Tips from our pharmacists for people taking the medication
NitrofurantoinBactrimAugmentinCetraxal
  • Take it with food (ideally breakfast and dinner) to prevent side effects and improve the drug's absorption.
  • Don't take it with antacids that contain magnesium.
  • It's common to feel better before you're supposed to stop taking Macrobid (Nitrofurantoin), but take it for the entire time your doctor prescribed it. Skipping doses or stopping early can lower the drug's effectiveness and increase the chance that the drug won't work as well next time.
  • Take this medication exactly how your doctor tells you to.
  • Can make your skin more sensitive to the sun.
  • Drink plenty of liquids when taking the medication.
  • Can cause diarrhea, nausea or vomiting.
  • Can cause rash.
  • Take this medication exactly as your doctor tells you to.
  • Take each dose with a meal since it may cause an upset stomach.
  • If you are taking birth control pills, this can make it less effective.
  • Store the suspension in the refrigerator. All other forms can be kept at room temperature.
  • Each vial is used for only one dose, so dispose of the container after using it.
  • Warm the dose by holding it in your hand for a minute before using it.
  • Lie on your side with your affected ear upwards. Put a drop in the ear and lie there for a minute or two before getting up.
  • Don't use if you're allergic to or had a reaction to ciprofloxacin or other quinolone-type antibiotics.
  • Stop using [name_ common] if a rash forms in or around the ear.
  • Avoid getting it in your eyes or mouth.
Learn more
More about NitrofurantoinSide effectsReviews & ratingsAlternativesFDA package insert
More about BactrimSide effectsReviews & ratingsFDA package insert
More about AugmentinSide effectsReviews & ratingsFDA package insert
More about CetraxalSide effectsReviews & ratingsFDA package insert