Prescription onlyNo lower cost generic available

Nolvadex Alternatives

(Tamoxifen)

  • Pill
  • Liquid
  • Breast cancer (treatment and prevention)
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Compare Nolvadex (Tamoxifen) to alternatives

These medications are comparable to Nolvadex (Tamoxifen) or used for similar purposes.

Nolvadex
(Tamoxifen)

Arimidex
(Anastrozole)

Aromasin
(Exemestane)

Femara
(Letrozole)

Lowers risk of and treats breast cancer. Nolvadex (Tamoxifen) is an effective, first-line option for certain types of breast cancers, but it has many severe side effects and needs a lot of monitoring.Coming soon.Coming soon.Coming soon.
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Reviews & ratings
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Side effects
NolvadexArimidexAromasinFemara
  • Vaginal discharge 15%
  • Irregular menses 6%
  • Weight loss (>5%) 5%
  • Any side effect 5%
  • Skin changes 4%
  • Holding water 2%
  • Nausea 2%
  • Thrombocytopenia 2%
More Nolvadex side effects »

We haven’t found good data for Arimidex side effects.

FDA side effect reports for Arimidex »

We haven’t found good data for Aromasin side effects.

FDA side effect reports for Aromasin »

We haven’t found good data for Femara side effects.

FDA side effect reports for Femara »
How it works
NolvadexArimidexAromasinFemara
Nolvadex (Tamoxifen) is an estrogen receptor antagonist. It stops tumor growth by blocking the effects of estrogen in breast tissue.Coming soon.Coming soon.Coming soon.
Type of medication
NolvadexArimidexAromasinFemara
Anticancer
Estrogen receptor antagonist
Prescription only
Coming soon.
Coming soon.
Coming soon.
Available as
NolvadexArimidexAromasinFemara
  • Pill
  • Liquid
  • Pill
  • Pill
  • Pill
Used for (click to learn more)
NolvadexArimidexAromasinFemara
  • Breast cancer (treatment and prevention)
  • Breast cancer
  • Breast cancer
  • Breast cancer
Risk factors for serious side effects
NolvadexArimidexAromasinFemara
    • Women of childbearing age
      • Current liver problems
        Detailed Nolvadex (Tamoxifen) risks & warnings »
        Coming soon.Coming soon.Coming soon.
        Pregnancy category
        NolvadexArimidexAromasinFemara
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        XFDA pregnancy category (Unsafe)

        Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take Nolvadex (Tamoxifen) once a day with a full glass of water. It can be taken with or without food.
        No specific food-related info.No specific food-related info.No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
        Sleep
        No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
        Weight
        No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
        Upsides and benefits
        NolvadexArimidexAromasinFemara
        • In studies, postmenopausal women who were at high risk for breast cancer took Nolvadex (Tamoxifen) for 5 years and lowered their risk by about 50%.
        • Nolvadex (Tamoxifen) is the only medicine approved to lower risk of breast cancer regardless of menopausal status. Other medicines are approved only for postmenopausal women.
        • Effective in treating metastatic breast cancer in men and women.
        • Available in both tablets and a sugar-free solution.
        Coming soon.Coming soon.Coming soon.
        Downsides and risks
        NolvadexArimidexAromasinFemara
        • If you're taking Nolvadex (Tamoxifen) to lower your risk for breast cancer, it can raise your risk of having a stroke or getting a blood clot, especially if you have a history of blood clots or you're currently taking a blood thinner, like warfarin. Tell your doctor about any health conditions before you start taking Nolvadex (Tamoxifen).
        • Can raise the risk of fractures in premenopausal women.
        • There are many drug interactions, including antidepressants and other chemotherapy (anti-cancer) medicines. Talk to your doctor or pharmacist before making any changes.
        • Requires regular blood tests and doctor exams to monitor for side effects.
        • Not the best choice if you have eye or liver problems.
        Coming soon.Coming soon.Coming soon.
        Tips from our pharmacists for people taking the medication
        NolvadexArimidexAromasinFemara
        • Nolvadex (Tamoxifen) can raise your risk of getting uterine or endometrial cancer. Talk to your doctor if you have abnormal vaginal bleeding or an irregular menstrual cycle.
        • Common side effects include hot flashes, vaginal discharge, nausea, and vomiting.
        • Take Nolvadex (Tamoxifen) once a day with a full glass of water. It can be taken with or without food.
        • If you're taking the solution, make sure to keep it at room temperature and protect it from light. Throw it away after 3 months, even if you haven't finished all of it.
        • Drinking grapefruit juice with Nolvadex (Tamoxifen) can raise your risk of side effects.
        Coming soon.Coming soon.Coming soon.
        Learn more
        More about NolvadexSide effectsReviews & ratingsAlternativesFDA package insert
        More about ArimidexSide effectsReviews & ratingsFDA package insert
        More about AromasinSide effectsReviews & ratingsFDA package insert
        More about FemaraSide effectsReviews & ratingsFDA package insert