Prescription onlyLower-cost generic available


(Hydrocodone / Acetaminophen)

  • Pill
  • Oral solution
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Treats moderate to severe pain.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Norco (Hydrocodone / Acetaminophen) is a good option to treat pain as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addition. Learn more about these drugs and be sure to discuss the risks with your doctor.
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  • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Norco if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Norco, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.

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Side effects for Norco (Hydrocodone / Acetaminophen)

Manufacturers don’t say how common these side effects are

  • Abnormally slow breathing
  • Anxiety
  • Constipation
  • Dizziness
  • Drowsiness
  • Fear
  • Impairment of mental and physical performance
  • Intense emotional discomfort
  • Itching
  • Lack of energy
  • Lightheadedness
  • Mental clouding
  • Mood changes
  • Nausea
  • Psychic dependence
  • Sdedation
  • Skin rash
  • Spasm of vesical sphincters
  • Ureteral spasm
  • Urinary retention
  • Vomiting

What to expect when you start Norco (Hydrocodone / Acetaminophen)

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Tips from our pharmacists
  • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
  • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.

Risks and Warnings for Norco (Hydrocodone / Acetaminophen)

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    • Higher risk if:
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen

    The acetaminophen component in Norco (Hydrocodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Norco (Hydrocodone / Acetaminophen) can cause serious harm to your liver. You may develop life-threatening liver problems that need a liver transplant. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Norco (Hydrocodone / Acetaminophen).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Norco (Hydrocodone / Acetaminophen)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Upsides and downsides from our pharmacists
  • Avoid alcohol.
  • Just avoid alcohol and becareful not to take anymore then needed.
    Age: 27
    Gender: man
  • Upsides and downsides from our pharmacists
  • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
  • Tips from our pharmacists
  • Take it with food to lower the chance of an upset stomach.
  • Taking with food eases dizziness.
    Age: 48
    Gender: woman
    Taken for: Pain (moderate to moderately-severe)
    Duration taken: two years or more
Weight gain or loss
  • Risks from our pharmacists
  • Hydrocodone, one of the medications in Norco (Hydrocodone / Acetaminophen) passes into breast milk. Women with a history of long-term opioid use increase the risk of neonatal withdrawal syndrome. Symptoms in the newborn include irritability, vomiting, diarrhea, tremor and lack of weight gain. Opioid withdrawal in infants is a life-threatening emergency and needs medical help right away.