Prescription onlyClass: Neuro/psych


(dextromethorphan / quinidine)

Prescription onlyClass: Neuro/psych
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Lowers the number of episodes of sudden, frequent, uncontrollable crying or laughing that doesn't match how you feel.

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Our bottom line

Nuedexta (dextromethorphan / quinidine) is the only medicine approved for pseudobulbar affect. It is only available as a brand name, so it can have an expensive copay.

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  • Nuedexta (dextromethorphan / quinidine) is recommended as a first choice medicine for pseudobulbar affect.
  • Compared to other medicines used to treat this condition, Nuedexta (dextromethorphan / quinidine) has fewer and milder side effects.


  • Nuedexta (dextromethorphan / quinidine) is only available as a brand name, so it can have an expensive copay.
  • Nuedexta (dextromethorphan / quinidine) can cause dizziness and might make you more likely to fall.
  • Nuedexta (dextromethorphan / quinidine) can cause changes in heartbeat. If you’ve had heart rhythm problems or heart disease, it might not be a good medicine for you.
How it works

Nuedexta (dextromethorphan / quinidine) is a combination of 2 medicines: dextromethorphan and quinidine. It's not clear how dextromethorphan helps maintain your mood. Quinidine slows the breakdown of dextromethorphan in the body.

What to expect when you take Nuedexta (dextromethorphan / quinidine) for Pseudobulbar affect

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Side effect rates for Nuedexta (dextromethorphan / quinidine)

216 From clinical trials of Nuedexta / Pseudobulbar affect (Dextromethorphan 20 mg/ quinidine sulfate 10 mg twice daily)
  • Diarrhea
  • Dizziness
  • Cough
  • Vomiting
  • Weakness
  • Swelling in arms and legs
  • Urinary tract infections
  • Flu
  • Liver damage
  • Gas

Risks and Warnings for Nuedexta (dextromethorphan / quinidine)

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    • Higher risk if:
    • Allergy to quinine or mefloquine

    Rare life-threatening allergic reactions have been reported with quinidine, a component of Nuedexta (dextromethorphan / quinidine). This is more common if you're allergic to quinine or mefloquine. If you suddenly have a high fever, chills, nausea or vomiting, call your doctor right away and stop taking it.

Common concerns from people taking Nuedexta (dextromethorphan / quinidine)

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Kidneys and liver
  • Hepatitis and liver damage have been reported rarely in people who've taken Nuedexta (dextromethorphan / quinidine). This usually happens in the first few weeks. Call your doctor right away if you suddenly develop a high fever and you haven't been sick.