Prescription onlyLower-cost generic available



  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Ogen (Estropipate) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

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  • Available as a generic, which can be less expensive than other estrogen pills.
  • Ogen (Estropipate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Ogen (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.

Save on your next Ogen (Estropipate) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

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Side effects for Ogen (Estropipate)

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These are side effects of Ogen (Estropipate) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you start Ogen (Estropipate)

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Tips from our pharmacists
  • Take Ogen (Estropipate) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
  • Use the lowest dose possible of Ogen (Estropipate) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Ogen (Estropipate) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
  • Tell your doctor about any unusual vaginal bleeding.

Risks and Warnings for Ogen (Estropipate)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Ogen (Estropipate)

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The FDA category for this medication is X. It is advised that you: Unsafe
  • Upsides and downsides from our pharmacists
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.