Prescription onlyNo lower cost generic available

Ogen Vaginal Cream

(Estropipate)

Prescription onlyNo lower cost generic available
  • Vaginal cream, gel, or ointment
  • Vaginal dryness and inflammation
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Relieves vaginal dryness due to menopause.

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Our bottom line

Ogen Vaginal Cream (Estropipate) works well for vaginal problems caused by menopause. It has fewer side effects than estrogen pills, but you might still need to use it every day.

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Upsides

  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).

Downsides

  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you have to use Ogen Vaginal Cream (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
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Side effect rates for Ogen Vaginal Cream (Estropipate)

Risks and Warnings for Ogen Vaginal Cream (Estropipate)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Ogen Vaginal Cream (Estropipate)

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Pregnancy
Pain
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).