Prescription onlyNo lower cost generic available

Ogen Vaginal Cream

(Estropipate)

  • Vaginal cream, gel, or ointment
  • Vaginal dryness and inflammation
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Relieves vaginal dryness due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Ogen Vaginal Cream (Estropipate) works well for vaginal problems caused by menopause. It has fewer side effects than estrogen pills, but you might still need to use it every day.

  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Generally works well with few side effects.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • The cream can weaken latex (rubber) condoms, cervical caps, and diaphrams. Don't use these within 72 hours after a dose.
  • Inserting the applicator can possibly cause discomfort or infection.
  • If you have your uterus, you have to use Ogen Vaginal Cream (Estropipate) with another hormone called progestin to lower your risk of uterine cancer.
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Side effects for Ogen Vaginal Cream (Estropipate)

Manufacturers don’t say how common these side effects are

  • Abdominal cramps
  • Abnormal jerking movements
  • Aggravation of porphyria
  • Bloating
  • Breast tenderness and/or enlargement
  • Change in amount of cervical secretion.
  • Changes in libido
  • Changes in vaginal bleeding
  • Chloasma or melasma
  • Cholestatic jaundice
  • Dizziness
  • Erythema multiforme
  • Excessive hair growth
  • Headache
  • Hemorrhagic eruption
  • Increase in size of uterine leiomyomata.
  • Increase or decrease in weight
  • Increased incidence of gallbladder disease
  • Intolerance of contact lenses
  • Loss of scalp hair
  • Mental depression
  • Migraine
  • Nausea
  • Reduced carbohydrate tolerance
  • Steepening of corneal curvature
  • Swelling due to excess fluid
  • Tender red bumps under skin
  • Vaginal candidiasis.
  • Vomiting

What to expect when you take Ogen Vaginal Cream (Estropipate)

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Tips from our pharmacists
  • Apply Ogen Vaginal Cream (Estropipate) directly to your vagina daily.
  • Attach the applicator to the tube and squeeze it to get your dose into the applicator. Insert the applicator deeply into your vagina and press the plunger to release all the medicine.
  • Best used at bedtime to increase effectiveness.
  • Consider wearing a panty liner.
  • Clean the applicator with soap and warm water after each use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.
  • Tell your doctor about any unusual vaginal bleeding.

Risks and Warnings for Ogen Vaginal Cream (Estropipate)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Ogen Vaginal Cream (Estropipate)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Sex
  • Upsides and downsides from our pharmacists
  • No vaginal sex immediately after using Ogen Vaginal Cream (Estropipate) to prevent your partner from being exposed to the medicine.
  • Ogen Vaginal Cream (Estropipate) relieves vaginal dryness and irritation to make sex more enjoyable.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because over time, Ogen Vaginal Cream (Estropipate) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).