Prescription or OTCLower-cost generic available

Prilosec

(Omeprazole)

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Treats heartburn and stomach ulcers.

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Prescription or OTCLower-cost generic available

Our pharmacists’ bottom line

Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.

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  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.

Save on your next Prilosec (Omeprazole) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

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Side effects for Prilosec (Omeprazole)

From clinical trials of Omeprazole / Any condition ( 3096)

  • Upper respiratory infectionUpper respiratory infection75% for Omeprazole vs.0% for placebo
  • FeverFever33% for Omeprazole vs.0% for placebo
  • Upper respiratory infectionUpper respiratory infection19% for Omeprazole vs.0% for placebo
  • HeadacheHeadache7% for Omeprazole vs.0% for placebo
  • Abdominal painAbdominal pain5% for Omeprazole vs.0% for placebo
  • NauseaNausea4% for Omeprazole vs.0% for placebo
  • DiarrheaDiarrhea4% for Omeprazole vs.0% for placebo
  • Accidental injuriesAccidental injuries4% for Omeprazole vs.0% for placebo
  • Passing gasPassing gas3% for Omeprazole vs.0% for placebo
  • VomitingVomiting3% for Omeprazole vs.0% for placebo

What to expect when you take Prilosec (Omeprazole) for Reduces stomach acid

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Tips from our pharmacists
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
  • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.

Risks and Warnings for Prilosec (Omeprazole)

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  • Heartburn and feelings of upset stomach can be warning signs of a more serious stomach problem or cancer. If you need to take Prilosec (Omeprazole) for 2 weeks or more go see a doctor. It's safest to get checked out to make sure you do not have a serious stomach condition.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Prilosec (Omeprazole)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Food
  • Tips from our pharmacists
  • Take 1 hour before a meal.
  • I take 10mg every morning at least an hour before I eat something. As long as I follow this rule every day, I never have heartburn. If I don't, I will get heartburn regularly over even the most mildest foods.
    Age: 33
    Gender: Man
    Taken for: Heartburn
    Duration taken: Two years or more
  • Omeprazole has always worked well for me. Without it id always have really bad heartburn. Best if taken an hour or so before a meal I always take mine an hour before supper since supper is always my biggest meal of the day
    Age: 52
    Gender: Man
    Taken for: Gastroesophageal Reflux Disease (GERD)
    Duration taken: Two years or more
  • Taking it every day 30mins before breakfast results in no heartburn at all. But i´m concerned about long term side effects like problems in B12 inhibit, calcium, colesterol
    Age: 34
    Gender: Man
    Taken for: Gastroesophageal Reflux Disease (GERD)
    Duration taken: Two years or more