Prescription or OTCLower-cost generic availableClass: Gastrointestinal

Prilosec Alternatives

(omeprazole)

Prescription or OTCLower-cost generic availableClass: Gastrointestinal
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Compare Prilosec (omeprazole) to alternatives

These medications are comparable to Prilosec (omeprazole) or used for similar purposes.

Prilosec
(omeprazole)

Nexium
(esomeprazole)

Alka-Seltzer Original
(aspirin / citric acid / sodium bicarbonate)

Pepcid
(famotidine)

Zegerid
(omeprazole / sodium bicarbonate)

Rolaids
(calcium carbonate / magnesium hydroxide)

Tums
(calcium carbonate)

Maalox
(aluminum / magnesium / simethicone)

Zantac 75
(ranitidine)

Tagamet
(cimetidine)

Protonix
(pantoprazole)

Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Nexium (Esomeprazole) gives you long-lasting heartburn relief. But this purple pill ain't cheap! The generic forms of alternative drugs work just as well, and are usually less expensive.Relieves heartburn, headache, and body pains. Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn, ulcers, and acid tummy. Zegerid (Omeprazole / Sodium Bicarbonate) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn and acid tummy. Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.Relieves heartburn. Tums (Calcium Carbonate) gives quick relief for heartburn, but don't expect it to last all day.Relieves heartburn and acid tummy. Maalox (Aluminum / Magnesium / Simethicone) gives quick relief for heartburn, gas, and bloating. It may not be as effective or last as long as alternative antacids though.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.
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Reviews & ratings
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5.53Omeprazole
Reviews for Prilosec (omeprazole)
80%
of people (All ages) say Prilosec (omeprazole) is worth it
59%
say it works well
8%
say it's a big hassle
1167 reviews
Have you used Prilosec (omeprazole)?
Worth itNot sureNot worth it
Reviews for Nexium (esomeprazole)
75%
-5% worse vs. Prilosec (omeprazole)
59%
Same vs. Prilosec (omeprazole)
11%
-3% worse vs. Prilosec (omeprazole)
1239 reviews
Have you used Nexium (esomeprazole)?
Worth itNot sureNot worth it
Reviews for Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)
81%
+1% better vs. Prilosec (omeprazole)
52%
-7% worse vs. Prilosec (omeprazole)
8%
Same vs. Prilosec (omeprazole)
1055 reviews
Have you used Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate)?
Worth itNot sureNot worth it
Reviews for Pepcid (famotidine)
75%
-5% worse vs. Prilosec (omeprazole)
41%
-18% worse vs. Prilosec (omeprazole)
8%
Same vs. Prilosec (omeprazole)
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Reviews for Zegerid (omeprazole / sodium bicarbonate)
72%
-8% worse vs. Prilosec (omeprazole)
55%
-4% worse vs. Prilosec (omeprazole)
12%
-4% worse vs. Prilosec (omeprazole)
Have you used Zegerid (omeprazole / sodium bicarbonate)?
Worth itNot sureNot worth it
Reviews for Rolaids (calcium carbonate / magnesium hydroxide)
75%
-5% worse vs. Prilosec (omeprazole)
37%
-22% worse vs. Prilosec (omeprazole)
7%
+1% better vs. Prilosec (omeprazole)
1089 reviews
Have you used Rolaids (calcium carbonate / magnesium hydroxide)?
Worth itNot sureNot worth it
Reviews for Tums (calcium carbonate)
82%
+2% better vs. Prilosec (omeprazole)
43%
-16% worse vs. Prilosec (omeprazole)
5%
+3% better vs. Prilosec (omeprazole)
1373 reviews
Have you used Tums (calcium carbonate)?
Worth itNot sureNot worth it
Reviews for Maalox (aluminum / magnesium / simethicone)
69%
-11% worse vs. Prilosec (omeprazole)
30%
-29% worse vs. Prilosec (omeprazole)
9%
-1% worse vs. Prilosec (omeprazole)
213 reviews
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
Reviews for Zantac 75 (ranitidine)
72%
-8% worse vs. Prilosec (omeprazole)
44%
-15% worse vs. Prilosec (omeprazole)
7%
+1% better vs. Prilosec (omeprazole)
1062 reviews
Have you used Zantac 75 (ranitidine)?
Worth itNot sureNot worth it
Reviews for Tagamet (cimetidine)
63%
-17% worse vs. Prilosec (omeprazole)
36%
-23% worse vs. Prilosec (omeprazole)
12%
-4% worse vs. Prilosec (omeprazole)
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Reviews for Protonix (pantoprazole)
68%
-12% worse vs. Prilosec (omeprazole)
51%
-8% worse vs. Prilosec (omeprazole)
13%
-5% worse vs. Prilosec (omeprazole)
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Side effects
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Upper respiratory infection 75%
  • Fever 33%
  • Headache 7%
  • Abdominal pain 5%
  • Nausea 4%
  • Diarrhea 4%
  • Accidental injuries 4%
  • Passing gas 3%
  • Vomiting 3%
More Omeprazole side effects »
  • Diarrhea 3%
  • Headache 2%
  • Drowsiness 2%
  • Change in taste 7%
  • Abdominal pain 4%
  • Nausea 2%
  • Irritability 5%
  • Vomiting 5%
More Nexium side effects »

We haven’t found good data for Alka-Seltzer side effects.

FDA side effect reports for Alka-Seltzer »
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »

The Zegerid FDA package insert doesn’t have numbers about how common side effects are.

More about Zegerid side effects »

We haven’t found good data for Rolaids side effects.

FDA side effect reports for Rolaids »

We haven’t found good data for Tums side effects.

FDA side effect reports for Tums »

We haven’t found good data for Maalox side effects.

FDA side effect reports for Maalox »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
  • Abnormally large breasts in males 4%
  • Headache 2%
More Tagamet side effects »
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »
How it works
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Nexium (Esomeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) is a combination medicine. Sodium bicarbonate is an antacid that relieves heartburn and acid tummy (indigestion). Aspirin is a pain reliever that treats headache and body pains.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Zegerid (Omeprazole / Sodium Bicarbonate) is a type of antacid called a proton pump inhibitor. It blocks the release of acid in your stomach, which treats heartburn and helps ulcers heal.Rolaids (Calcium Carbonate / Magnesium Hydroxide) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).Tums (Calcium Carbonate) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).Maalox (Aluminum / Magnesium / Simethicone) is a combination medicine for stomach trouble. Aluminum and magnesium are antacids that relieve heartburn and acid tummy (indigestion). Simethicone relieves gas and bloating.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.
Type of medication
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
Prescription or OTC
Prescription or OTC
Over-the-counter
Prescription or OTC
Prescription or OTC
Over-the-counter
Over-the-counter
Over-the-counter
Prescription or OTC
Prescription or OTC
Prescription only
Available as
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Extended release
  • Extended release
  • Chewable tablet
  • Effervescent tablet
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Chewable tablet
  • Liquid
  • Chewable tablet
  • Liquid
  • Chewable tablet
  • Liquid
  • Pill
  • Oral solution
  • Injection
  • Pill
  • Liquid
  • Pill
  • Packet
Used for
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
Risk factors for serious side effects
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Prilosec (omeprazole) risks & warnings »
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Nexium (esomeprazole) risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Age 65 or older
  • Congestive heart failure (CHF)
  • High blood pressure
Detailed Alka-Seltzer Original (aspirin / citric acid / sodium bicarbonate) risks & warnings »
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Zegerid (omeprazole / sodium bicarbonate) risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Hyperparathyroid disease
  • Taking high doses of Vitamin D
  • Previous kidney stones
Detailed Rolaids (calcium carbonate / magnesium hydroxide) risks & warnings »
  • Current kidney disease
  • Kidney dialysis
  • Hyperparathyroid disease
  • Taking high doses of Vitamin D
  • Previous kidney stones
Detailed Tums (calcium carbonate) risks & warnings »
  • Age 65 or older
  • Current kidney disease
Detailed Maalox (aluminum / magnesium / simethicone) risks & warnings »
  • Current kidney problems
  • Current liver problems
  • Acute Porphyria
  • History of Phenylketonuria (PKU)
Detailed Zantac 75 (ranitidine) risks & warnings »
  • Current kidney disease
  • Current liver disease
  • Age 50 or older
  • Current severe illness
  • Autoimmune disease
Detailed Tagamet (cimetidine) risks & warnings »
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
  • People with lupus
Detailed Protonix (pantoprazole) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Nexium.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Nexium.
No interactions related info.
  • Few drug interactions.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
No interactions related info.
  • You need to separate Tums from some medications to avoid interactions.
No interactions related info.
  • Few drug interactions.
  • Has more drug interactions than zantac and pepcid.
No interactions related info.
Food
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Take 1 hour before a meal.
  • Take 1 hour before a meal.
  • Take it with food to lower the chance of an upset stomach.
No food related info.
  • Take 1 hour before a meal.
No food related info.No food related info.
  • Take 1-3 hours after a meal.
No food related info.No food related info.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
Kidneys and liver
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
No kidneys and liver related info.No kidneys and liver related info.
  • If you have kidney or hyperparathyroid disease Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) can build up in your blood. This may can cause toxic levels of sodium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate); a different antacid would be better for you.
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
No kidneys and liver related info.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
  • If you have kidney or hyperparathyroid disease Rolaids (Calcium Carbonate / Magnesium Hydroxide) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Rolaids (Calcium Carbonate / Magnesium Hydroxide); a different antacid would be better for you.
  • Rolaids (Calcium Carbonate / Magnesium Hydroxide) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Rolaids (Calcium Carbonate / Magnesium Hydroxide). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
  • If you have kidney or hyperparathyroid disease Tums (Calcium Carbonate) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Tums (Calcium Carbonate); a different antacid would be better for you.
  • Tums (Calcium Carbonate) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Tums (Calcium Carbonate). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
  • People with kidney disease may need to avoid Maalox. Ask your doctor.
  • If you have kidney disease Maalox (Aluminum / Magnesium / Simethicone) can build up in your blood. This may can cause toxic levels of aluminum or magnesium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Maalox (Aluminum / Magnesium / Simethicone); a different antacid would be better for you.
  • People with kidney disease may need to take a lower dose.
  • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
  • People with kidney disease may need to take a lower dose.
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
Pain
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
Upsides and benefits
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Most people can take Nexium without any noticeable day-to-day side effects.
  • Nexium lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Most people can take Zegerid without any noticeable day-to-day side effects.
  • Zegerid lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
  • Most people can take Ranitidine without any noticeable day-to-day side effects.
  • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Most people can take Cimetidine without any noticeable day-to-day side effects.
  • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
Downsides and risks
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Nexium long-term.
  • Can be expensive—especially the purple brand-name pill. Other alternatives are usually cheaper than Nexium and work just as well.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Nexium.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Zegerid long-term.
  • Although the generic is affordable, other medications might still be cheaper than Zegerid.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Zegerid.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some chalky aftertaste.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some chalky aftertaste.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Some people don't care for the taste.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
  • Has more drug interactions than zantac and pepcid.
  • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
Tips from our pharmacists for people taking the medication
OmeprazoleNexiumAlka-SeltzerPepcidZegeridRolaidsTumsMaaloxZantacTagametpantoprazole
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
  • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
  • When using Nexium long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Nexium.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Nexium.
  • Don't take Alka-Seltzer if you're allergic to aspirin.
  • Take it with food to lower the chance of an upset stomach.
  • This medicine isn't recommended for kids 12 and younger because it has aspirin in it.
  • Stop taking this right away and talk to your doctor if you have ringing in your ears, rash, trouble breathing, unusual bleeding, or nausea or vomiting that doesn't go away.
  • Having a dental or medical procedure? You may need to stop taking this before the big day. Ask your dentist or doctor.
  • Alka-Seltzer contains sodium. If you need to follow a low sodium diet a different medication would be better for you.
  • Not a good choice if you have stomach bleeding, bleeding problems, diabetes, or gout, or if you're taking medicines to thin your blood.
  • Short-term treatment of ulcers and acid reflux.
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Zegerid.
  • If you've been having heartburn for 3 months or more, talk to your doctor before taking Zegerid. Get a check-up to make sure you aren't having a more serious stomach problem.
  • Talk to your doctor if you're still having heartburn after two weeks of use. Don't keep taking Zegerid; get checked-out first.
  • Take at the first sign of discomfort.
  • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
  • Take 1-2 hours apart from other medication that you take by mouth.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
  • Don't take if you have high blood calcium levels.
  • Take at the first sign of discomfort.
  • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
  • You need to separate Tums from some medications to avoid interactions.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
  • Don't take if you have high blood calcium levels.
  • Take 1-3 hours after a meal.
  • Take 1-2 hours apart from other medication that you take by mouth.
  • Tell your doctor if you have severe diarrhea or constipation.
  • People with kidney disease may need to avoid Maalox. Ask your doctor.
  • Works best if you take it with a full glass of water.
  • Starts working in one hour.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease may need to take a lower dose.
  • Works best if you take it with a full glass of water.
  • Starts working in one hour.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease may need to take a lower dose.
  • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
  • Take the tablet form of Protonix (pantoprazole) with or without food.
  • The medicine should be swallowed whole and not to to be chewed or crushed.
  • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
  • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
  • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
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