Prescription onlyClass: Endocrine


(pioglitazone / alogliptin)

Prescription onlyClass: Endocrine
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Lowers blood sugar.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Oseni (pioglitazone / alogliptin) combines 2 medicines into one pill, but neither are first-choice treatment for diabetes.


  • Lowers A1c (average blood sugar over time) levels by 1.5%.
  • Available as a single-pill taken once daily.


  • Oseni (pioglitazone / alogliptin) may cause weight gain.
  • May not be good for people with heart or liver problems.
  • May cause bone fractures, especially in women.
  • May cause joint pain.
  • Raises your risk for bladder cancer.
How it works

Oseni (pioglitazone / alogliptin) contains 2 anti-diabetic medicines. Pioglitazone increases your body's sensitivity to insulin while alogliptin increases insulin and decreases glucagon production.

What to expect when you take Oseni (pioglitazone / alogliptin) for Type 2 diabetes

Skip what to expect section. Skip to Risks & Warnings section.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Oseni (pioglitazone / alogliptin)

  • Low blood sugar

Risks and Warnings for Oseni (pioglitazone / alogliptin)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Heart failure
    • Congestive heart failure
    • Heart disease

    Oseni (pioglitazone / alogliptin) can cause heart failure or worsen your heart failure in people who already have it. Tell your doctor if you have heart disease. Call your doctor right away if you have shortness of breath, a big weight gain, a heartbeat that is not normal, or swelling in the arms or legs that is new or worse.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Oseni (pioglitazone / alogliptin)

Final section. Do you want to return to drug navigation?
  • Avoid alcohol while taking Oseni (pioglitazone / alogliptin) as it may cause severely low blood sugar.
  • Take by mouth with or without food.
  • May cause joint pain.
  • Oseni (pioglitazone / alogliptin) may cause weight gain.