Prescription onlyLower-cost generic available



  • Pill
  • Extended release
  • Oral solution
  • Liquid
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Treats severe pain.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.

Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.
Worth it?Is it worth it?
Works well?Does it work?
Hassle?Is it a hassle?
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Can have fewer side effects than other opioid pain relievers.
  • Generally considered to be stronger than morphine.
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
  • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
  • Long-term use will likely cause physical dependence.
  • Need be weaned slowly off the medicine after using it longer than two weeks.

Save on your next Oxycontin (Oxycodone) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Oxycontin (Oxycodone)

From clinical trials of Oxycodone / Any condition 

  • ConfusionConfusion5% for Oxycodone vs.0% for placebo
  • Abdominal painAbdominal pain5% for Oxycodone vs.0% for placebo
  • IndigestionIndigestion5% for Oxycodone vs.0% for placebo
  • Upset stomachUpset stomach5% for Oxycodone vs.0% for placebo
  • ChillsChills5% for Oxycodone vs.0% for placebo
  • FeverFever5% for Oxycodone vs.0% for placebo
  • Loss of appetiteLoss of appetite5% for Oxycodone vs.0% for placebo
  • TwitchingTwitching5% for Oxycodone vs.0% for placebo
  • Abnormal dreamsAbnormal dreams5% for Oxycodone vs.0% for placebo
  • AnxietyAnxiety5% for Oxycodone vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Abnormally slow breathing
  • Cns depression
  • Drug abuse, addiction, and dependence
  • Gastrointestinal effects
  • Hypotensive effects
  • Seizures

What to expect when you start Oxycontin (Oxycodone)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Can make you dizzy or drowsy.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.

Risks and Warnings for Oxycontin (Oxycodone)

Skip Risks and Warnings section. Skip to Tips section.
    • Higher risk if:
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems

    Taking too much Oxycontin (Oxycodone) can cause irregular or slow breathing that can put you in a coma and can cause death. Oxycontin (Oxycodone) should be swallowed whole, don't ever crush or chew. If your lips and fingers start turning blue from low oxygen, see a doctor immediately. In the hospital, doctors can give you a medicine that reverses the effects of Oxycontin (Oxycodone). Don't take more than your doctor prescribes. Always check with your doctor before starting any new medicines or supplements.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Oxycontin (Oxycodone)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is B. It is advised that you: Probably safe
  • Upsides and downsides from our pharmacists
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • Tips from our pharmacists
  • Take it with food to lower the chance of an upset stomach.
  • Taken with Tramadol, both are opiates. Stopped taking both within a week, caused major depression with suicidal tendencies. Loss of appetite and confusion, including sleep deprivation. Do not take both meds together under any circumstances.
    Age: 56
    Gender: man
    Taken for: Pain (moderate to severe)
  • Taking standard release version for breakthrough pain. It's very effective but does cause constipation. Taking a little too much or too frequently has a massive effect on sleep - in a bad way.
    Age: 41
    Gender: man
    Taken for: Chronic pain (severe)
    Duration taken: two years or more
  • sleep troubles if taken after 10 pm sometimes
    Taken for: Chronic pain (severe)
    Duration taken: two years or more