Prescription onlyLower-cost generic available


(Oxycodone / Ibuprofen)

  • Pill
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Treats moderate to severe pain.

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Prescription onlyLower-cost generic available

Our bottom line

Combunox (Oxycodone / Ibuprofen) is a strong pain reliever that also lowers inflammation, but it can't be used more than seven days.

Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.


  • The ibuprofen in Combunox (Oxycodone / Ibuprofen) helps lower inflammation and pain. Since it's not an opioid, it reduces the amount of narcotics you'll need to use to treat your pain.
  • Oxycodone and ibuprofen well work together to relieve short-term muscle and bone-related pain.
  • Can be used to treat moderate to severe pain accompanied by a fever.


  • Combunox (Oxycodone / Ibuprofen) can only be used for short-term pain, less than seven days.
  • Isn't used to treat arthritis pain or other long-term causes of pain.
  • Can have side effects caused by both medications.
  • There are a lot of medical conditions that'll prevent you from taking this medication, so you'll need to check with your doctor if it's safe for you to take.
  • It's a dangerous medication for pregnant women.

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  • (60) 5mg/400mg tablet
  • Cost for (60) 5mg/400mg tablets of Combunox (Oxycodone / Ibuprofen) at pharmacies

What to expect when you take Combunox (Oxycodone / Ibuprofen)

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Tips from our pharmacists
  • Combunox (Oxycodone / Ibuprofen) is a combination of two pain medications. It shouldn't be used for more than seven days.
  • Starts treating pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • The ibuprofen can cause bleeding problems, including stomach ulcers.
  • Don't use it if you're taking 'blood thinner' medications or aspirin.
  • Avoid any activity that requires you to be alert until you know how the medication affects you.
  • Be sure your doctor is aware of all other medications you're taking, including OTC products and herbals.
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Side effects for Combunox (Oxycodone / Ibuprofen)

From clinical trials of oxycodone ibuprofen / Moderate to severe pain (5/400 mg)  ( 1238)

  • NauseaNausea9% for Oxycodone/Ibuprofen vs.7% for placebo
  • DrowsinessDrowsiness7% for Oxycodone/Ibuprofen vs.2% for placebo
  • VomitingVomiting5% for Oxycodone/Ibuprofen vs.3% for placebo
  • DizzinessDizziness5% for Oxycodone/Ibuprofen vs.3% for placebo
  • SweatSweat2% for Oxycodone/Ibuprofen vs.0% for placebo
  • Passing gasPassing gas1% for Oxycodone/Ibuprofen vs.0% for placebo

Risks and Warnings for Combunox (Oxycodone / Ibuprofen)

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    • Higher risk if:
    • Children age 18 and younger

    Even one dose of Combunox (Oxycodone / Ibuprofen) can be too much for children. Keep the medicine out of reach from children. If you suspect your child has taken Combunox (Oxycodone / Ibuprofen), watch for decreased activity, extreme tiredness, and lips and fingers turning blue from low oxygen. Go to a hospital immediately and the doctors can give a medicine that reverses the effects of Combunox (Oxycodone / Ibuprofen).

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Combunox (Oxycodone / Ibuprofen)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Tips from our pharmacists
  • Take it with a meal or a snack to prevent an upset stomach.
Kidneys and liver
  • Risks from our pharmacists
  • Combunox (Oxycodone / Ibuprofen), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk for kidney problems. It's important to get lab tests to check your kidney function periodically if you use Combunox (Oxycodone / Ibuprofen) for long periods of time.