Prescription onlyLower-cost generic availableClass: Pain


(oxycodone / ibuprofen)

Prescription onlyLower-cost generic availableClass: Pain
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Treats moderate to severe pain.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Combunox (Oxycodone / Ibuprofen) is a strong pain reliever that also lowers inflammation, but it can't be used more than seven days.

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Prices and coupons for 60 (5mg/400mg) tablets of oxycodone / ibuprofen


  • The ibuprofen in Combunox (Oxycodone / Ibuprofen) helps lower inflammation and pain. Since it's not an opioid, it reduces the amount of narcotics you'll need to use to treat your pain.
  • Oxycodone and ibuprofen well work together to relieve short-term muscle and bone-related pain.
  • Can be used to treat moderate to severe pain accompanied by a fever.


  • Combunox (Oxycodone / Ibuprofen) can only be used for short-term pain, less than seven days.
  • Isn't used to treat arthritis pain or other long-term causes of pain.
  • Can have side effects caused by both medications.
  • There are a lot of medical conditions that'll prevent you from taking this medication, so you'll need to check with your doctor if it's safe for you to take.
  • It's a dangerous medication for pregnant women.
How it works

Combunox (Oxycodone / Ibuprofen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Ibuprofen is a non-opioid pain reliever and lowers inflammation.

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Side effect rates for Combunox (oxycodone / ibuprofen)

1238 From clinical trials of Oxycodone Ibuprofen / Moderate to severe pain (5/400 mg)
  • Nausea
  • Drowsiness
  • Vomiting
  • Dizziness
  • Sweat

Risks and Warnings for Combunox (oxycodone / ibuprofen)

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    • Higher risk if:
    • Children age 18 and younger

    Even one dose of Combunox (Oxycodone / Ibuprofen) can be too much for children. Keep the medicine out of reach from children. If you suspect your child has taken Combunox (Oxycodone / Ibuprofen), watch for decreased activity, extreme tiredness, and lips and fingers turning blue from low oxygen. Go to a hospital immediately and the doctors can give a medicine that reverses the effects of Combunox (Oxycodone / Ibuprofen).

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Combunox (oxycodone / ibuprofen)

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  • Take it with a meal or a snack to prevent an upset stomach.
Kidneys and liver
  • Combunox (Oxycodone / Ibuprofen), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk for kidney problems. It's important to get lab tests to check your kidney function periodically if you use Combunox (Oxycodone / Ibuprofen) for long periods of time.
  • Can be used to treat moderate to severe pain accompanied by a fever.
  • Isn't used to treat arthritis pain or other long-term causes of pain.
  • Starts treating pain in 30 to 60 minutes.