Prescription onlyLower-cost generic availableClass: Pain

Combunox Alternatives

(oxycodone / ibuprofen)

Prescription onlyLower-cost generic availableClass: Pain
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Compare Combunox (oxycodone / ibuprofen) to alternatives

These medications are comparable to Combunox (oxycodone / ibuprofen) or used for similar purposes.

Combunox
(oxycodone / ibuprofen)

Percocet
(oxycodone / acetaminophen)

Treats moderate to severe pain. Combunox (Oxycodone / Ibuprofen) is a strong pain reliever that also lowers inflammation, but it can't be used more than seven days.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Reviews & ratings
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Have you used Combunox (oxycodone / ibuprofen)?
Worth itNot sureNot worth it
Reviews for Percocet
70%
-70% worse vs. Oxycodone Ibuprofen
49%
-49% worse vs. Oxycodone Ibuprofen
15%
+15% better vs. Oxycodone Ibuprofen
1399 reviews
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it
Side effects
Oxycodone IbuprofenPercocet
  • Nausea 2%
  • Drowsiness 5%
  • Vomiting 2%
  • Dizziness 2%
  • Sweat 2%
More Oxycodone Ibuprofen side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
How it works
Oxycodone IbuprofenPercocet
Combunox (Oxycodone / Ibuprofen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Ibuprofen is a non-opioid pain reliever and lowers inflammation.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
Oxycodone IbuprofenPercocet
Prescription onlyPrescription only
Available as
Oxycodone IbuprofenPercocet
  • Pill
  • Pill
  • Oral solution
Used for
Oxycodone IbuprofenPercocet
Risk factors for serious side effects
Oxycodone IbuprofenPercocet
  • Children age 18 and younger
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • History of heart attack
Detailed Combunox (oxycodone / ibuprofen) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Percocet (oxycodone / acetaminophen) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
Oxycodone IbuprofenPercocet
No alcohol related info.
  • Avoid alcohol.
Food
Oxycodone IbuprofenPercocet
  • Take it with a meal or a snack to prevent an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
Oxycodone IbuprofenPercocet
  • Combunox (Oxycodone / Ibuprofen), and similar medications in the NSAID family, can lower kidney function or cause permanent kidney damage. Taking the lowest dose for the shortest amount of time necessary can lower your risk for kidney problems. It's important to get lab tests to check your kidney function periodically if you use Combunox (Oxycodone / Ibuprofen) for long periods of time.
  • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
  • Don't take more than instructed to prevent liver damage.
Pain
Oxycodone IbuprofenPercocet
  • Starts treating pain in 30 to 60 minutes.
  • Can be used to treat moderate to severe pain accompanied by a fever.
  • Isn't used to treat arthritis pain or other long-term causes of pain.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
Sleep
Oxycodone IbuprofenPercocet
No sleep related info.
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
Oxycodone IbuprofenPercocet
  • The ibuprofen in Combunox (Oxycodone / Ibuprofen) helps lower inflammation and pain. Since it's not an opioid, it reduces the amount of narcotics you'll need to use to treat your pain.
  • Oxycodone and ibuprofen well work together to relieve short-term muscle and bone-related pain.
  • Can be used to treat moderate to severe pain accompanied by a fever.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides and risks
Oxycodone IbuprofenPercocet
  • Combunox (Oxycodone / Ibuprofen) can only be used for short-term pain, less than seven days.
  • Isn't used to treat arthritis pain or other long-term causes of pain.
  • Can have side effects caused by both medications.
  • There are a lot of medical conditions that'll prevent you from taking this medication, so you'll need to check with your doctor if it's safe for you to take.
  • It's a dangerous medication for pregnant women.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Tips from our pharmacists for people taking the medication
Oxycodone IbuprofenPercocet
  • Combunox (Oxycodone / Ibuprofen) is a combination of two pain medications. It shouldn't be used for more than seven days.
  • Starts treating pain in 30 to 60 minutes.
  • Take it with a meal or a snack to prevent an upset stomach.
  • The ibuprofen can cause bleeding problems, including stomach ulcers.
  • Don't use it if you're taking 'blood thinner' medications or aspirin.
  • Avoid any activity that requires you to be alert until you know how the medication affects you.
  • Be sure your doctor is aware of all other medications you're taking, including OTC products and herbals.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
Learn more
More about Oxycodone IbuprofenSide effectsAlternativesFDA package insert
Have you used Combunox (oxycodone / ibuprofen)?
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More about PercocetSide effectsReviews & ratingsFDA package insert
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it