Oxycontin Alternatives

Alternatives

Compare Oxycontin (Oxycodone) to alternatives

These medications are comparable to Oxycontin (Oxycodone) or used for similar purposes.

oxycodone

Norco
(Hydrocodone / Acetaminophen)

Ultram
(tramadol)

Percocet
(Oxycodone / Acetaminophen)

Ms Contin
(Morphine Sulfate)

Tylenol #3
(Acetaminophen / Codeine)

Treats severe pain. Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.Treats moderate to severe pain. Norco (Hydrocodone / Acetaminophen) is a good option to treat pain as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.Treats moderate to severe pain. Ultram (tramadol) works well for pain. Although it's a little weaker than other opioids, it can still be addictive.Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.Treats severe pain. Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Oxycodone
Reviews for Oxycodone
66%
of people (All ages) say Oxycodone is worth it
50%
say it works well
19%
say it's a big hassle
1241 reviews
Have you used Oxycontin (Oxycodone)?
Worth itNot sureNot worth it
Reviews for Norco
67%
-1% worse vs. Oxycodone
44%
+6% better vs. Oxycodone
13%
-6% worse vs. Oxycodone
1194 reviews
Have you used Norco (Hydrocodone / Acetaminophen)?
Worth itNot sureNot worth it
Reviews for Tramadol
61%
+5% better vs. Oxycodone
40%
+10% better vs. Oxycodone
16%
-3% worse vs. Oxycodone
642 reviews
Have you used Ultram (tramadol)?
Worth itNot sureNot worth it
Reviews for Percocet
70%
-4% worse vs. Oxycodone
49%
+1% better vs. Oxycodone
15%
-4% worse vs. Oxycodone
1399 reviews
Have you used Percocet (Oxycodone / Acetaminophen)?
Worth itNot sureNot worth it
Reviews for Morphine Sulfate
55%
+11% better vs. Oxycodone
43%
+7% better vs. Oxycodone
20%
+1% better vs. Oxycodone
541 reviews
Have you used Ms Contin (Morphine Sulfate)?
Worth itNot sureNot worth it
Reviews for Acetaminophen With Codeine
69%
-3% worse vs. Oxycodone
41%
+9% better vs. Oxycodone
9%
-10% worse vs. Oxycodone
581 reviews
Have you used Tylenol #3 (Acetaminophen / Codeine)?
Worth itNot sureNot worth it
Side effects
OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
  • Sweating 3%
  • Dry Mouth 4%
  • Asthenia 6%
  • Vomiting 5%
  • Dizziness 4%
  • Pruritus 11%
  • Constipation 16%
  • Nausea 12%
  • Somnolence 19%
More Oxycodone side effects »

The Norco FDA package insert doesn’t have numbers about how common side effects are.

More about Norco side effects »
  • Dyspepsia 5%
  • Dry Mouth 5%
  • Diarrhea 5%
  • Asthenia 6%
  • Sweating 6%
  • CNS Stimulation 7%
  • Pruritus 8%
  • Vomiting 9%
  • Sleepiness 16%
  • Headache 18%
More Tramadol side effects »

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »

The Morphine Sulfate FDA package insert doesn’t have numbers about how common side effects are.

More about Morphine Sulfate side effects »

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »
How it works
OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
Oxycontin (Oxycodone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.Norco (Hydrocodone / Acetaminophen) is a combination pain medicine. Hydrocodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.Ultram (tramadol) is an opioid pain reliever. Researchers don't know exactly how it works, but it alters certain brain chemicals to lower pain perception and improve mood.Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.Ms Contin (Morphine Sulfate) is an opioid medicine that works in the brain to lower pain perception.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Pill
  • Oral solution
  • Pill
  • Extended release
  • Extended release capsule
  • Dissolving tablet
  • Pill
  • Oral solution
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
  • Pill
  • Liquid
Used for
OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
Risk factors for serious side effects
OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Oxycontin (Oxycodone) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Norco (Hydrocodone / Acetaminophen) risks & warnings »
  • Pregnancy
  • Age 65 or greater
  • Overdose
  • Using alcohol, benzodiazepines or other medicines that slow breathing
  • Taking more than the prescribed dose
Detailed Ultram (tramadol) risks & warnings »
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Percocet (Oxycodone / Acetaminophen) risks & warnings »
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Ms Contin (Morphine Sulfate) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    No interactions related info.No interactions related info.
    • Ultram (tramadol) can interact with your other medicines, which can change how it affects your pain. Stopping these medicines while taking Ultram (tramadol) can make you more likely to have serious, life threatening side effects. Make sure your doctor and pharmacist know all the medicines you're taking, and let them know of any changes.
    No interactions related info.No interactions related info.No interactions related info.
    Alcohol
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    No alcohol related info.
    • Avoid alcohol.
    No alcohol related info.
    • Avoid alcohol.
    No alcohol related info.
    • Avoid alcohol.
    Food
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    • Take it with food to lower the chance of an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    • Take Ultram (tramadol) with food to avoid an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    No kidneys and liver related info.
    • The acetaminophen component in Norco (Hydrocodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Norco (Hydrocodone / Acetaminophen) can cause serious harm to your liver. You may develop life-threatening liver problems that need a liver transplant. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Norco (Hydrocodone / Acetaminophen).
    • Don't take more than instructed to prevent liver damage.
    • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
    • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
    • Don't take more than instructed to prevent liver damage.
    No kidneys and liver related info.
    • Don't take more than instructed to prevent liver damage.
    Pain
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
    • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
    • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
    • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • Good for chronic pain that requires around-the-clock relief.
    • Doesn't work for as-needed or quick pain relief.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Good for as-needed pain and control.
    Sleep
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common.
    No sleep related info.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    Upsides and benefits
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
    • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
    • Can have fewer side effects than other opioid pain relievers.
    • Generally considered to be stronger than morphine.
    • Combination pain medicine with an opiod component (hydrocodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    • Relieves moderate to severe pain. It has been shown to work as well as other opioid pain medications.
    • Compared to typical opioids, it provides unique pain relief and effects on your mood when taken regularly.
    • Has a lower chance of causing breathing problems compared to other typical opioids.
    • Doesn't cause as much constipation as other opioid pain medicines. Staying hydrated and taking laxatives can help treat this side effect.
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    • Provides longer relieve for moderate to severe pain to improve quality of life.
    • Good for chronic pain that requires around-the-clock relief.
    • Might have fewer side effects than other opioid pain relievers.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relieve for mild to moderate pain to improve quality of life.
    • Good for as-needed pain and control.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
    • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
    • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
    • Long-term use will likely cause physical dependence.
    • Need be weaned slowly off the medicine after using it longer than two weeks.
    • Dizziness and drowsiness is common.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Norco if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Norco, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    • Some people think it's weaker than other opioid pain medications. It can also cause more upset stomach.
    • Like other opioid pain relievers, Ultram (tramadol) has a high risk of addiction, abuse, misuse, overdose, and death.
    • The extended release version of Ultram (tramadol) should only be used for severe pain that requires daily, around-the-clock treatment once alternative treatments haven't worked.
    • It's a controlled substance regulated by the federal government. This means that your use of Ultram (tramadol) will be tracked to prevent potential prescription abuse.
    • Like all opioids, don't use when pregnant, since the baby can become dependent on it and have withdrawal symptoms after birth.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    • Doesn't work for as-needed or quick pain relief.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
    • Long term use will likely cause physical dependence.
    • Must be weaned slowly off the medicine after use longer than 2 weeks.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    OxycodoneNorcoTramadolPercocetMorphine SulfateAcetaminophen With Codeine
    • Opioid pain medicine that provides longer pain relief—up to 12 hours.
    • Works best when taken regularly instead of as-needed.
    • Especially useful for people with chronic pain problems.
    • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
    • Swallow it whole. Don't crush, chew, or split the medicine.
    • Can make you dizzy or drowsy.
    • Avoid activities that need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    • This is a combination pain medication. It contains both an opioid medicine and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain. Starts working in 30 minutes and pain relief lasts 4 to 6 hours.
    • Can make you dizzy or drowsy. Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • Starts working in one hour and works best if you take it regularly.
    • Can make you dizzy or drowsy, so avoid activities that need you to be fully alert until you know how this medicine affects you.
    • Take Ultram (tramadol) with food to avoid an upset stomach.
    • There are different doses for people who are older or who have liver or kidney disease, so work with your doctor to get the right dose.
    • Swallow the extended-release tablets whole. They're designed to release the drug slowly and breaking, crushing, or chewing them could cause a serious overdose.
    • Take the extended-release tablets exactly as your doctor and pharmacist tell you. If you forget, take it as soon as you remember. Don't take extra medicine to make up for a missed dose.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • Opioid pain medicine that provides longer pain relief—up to 12 hours.
    • Works best when taken regularly instead of as-needed.
    • Especially useful for people with chronic pain problems.
    • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
    • Swallow it whole. Don't crush, chew, or split the medicine.
    • Can make you dizzy or drowsy.
    • Avoid activities that need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    Learn more
    More about OxycodoneSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Oxycontin (Oxycodone)?
    Worth itNot sureNot worth it
    More about NorcoSide effectsReviews & ratingsFDA package insert
    Have you used Norco (Hydrocodone / Acetaminophen)?
    Worth itNot sureNot worth it
    More about TramadolSide effectsReviews & ratingsFDA package insert
    Have you used Ultram (tramadol)?
    Worth itNot sureNot worth it
    More about PercocetSide effectsReviews & ratingsFDA package insert
    Have you used Percocet (Oxycodone / Acetaminophen)?
    Worth itNot sureNot worth it
    More about Morphine SulfateSide effectsReviews & ratingsFDA package insert
    Have you used Ms Contin (Morphine Sulfate)?
    Worth itNot sureNot worth it
    More about Acetaminophen With CodeineSide effectsReviews & ratingsFDA package insert
    Have you used Tylenol #3 (Acetaminophen / Codeine)?
    Worth itNot sureNot worth it