Prescription onlyLower-cost generic available



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Treats heartburn and stomach ulcers.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.

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  • Most people can take Pantoprazole without any noticeable day-to-day side effects.
  • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
  • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
  • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.

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Side effects for Protonix (Pantoprazole)

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These are side effects of Protonix (Pantoprazole) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you start Protonix (Pantoprazole)

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Tips from our pharmacists
  • Take with or without food.
  • Swallow tablets whole; don't split, crush, or chew.
  • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
  • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.

Risks and Warnings for Protonix (Pantoprazole)

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  • Heartburn and feelings of upset stomach can be warning signs of a more serious stomach problem or cancer. If you need to take Protonix (Pantoprazole) for 2 weeks or more go see a doctor. It's safest to get checked out to make sure you do not have a serious stomach condition.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Protonix (Pantoprazole)

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The FDA category for this medication is B. It is advised that you: Probably safe
  • Tips from our pharmacists
  • Take with or without food.
  • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
  • since it has to be taken 30 minutes before breakfast, it does interfere with morning routine.
    Age: 54
    Gender: woman
    Taken for: Duodenal ulcer
    Duration taken: a few months