Prescription onlyLower-cost generic availableClass: Gastrointestinal



Prescription onlyLower-cost generic availableClass: Gastrointestinal
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Treats heartburn and excess release of stomach acid.

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Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

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Prices and coupons for 30 (40mg) tablets of pantoprazole


  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
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  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
How it works

Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.

What to expect when you take Protonix (pantoprazole) for Reduces stomach acid

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Side effect rates for Protonix (pantoprazole)

1555 From clinical trials of pantoprazole / GERD
  • Headache
  • Diarrhea
  • Nausea
  • Stomach pain
  • Vomiting
  • Gas
  • Dizziness
  • Joint pain

Risks and Warnings for Protonix (pantoprazole)

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    • Higher risk if:
    • Using multiple daily doses and/or for 1 year or longer
    • People age 65 or older
    • High risk of bone fractures

    Protonix (pantoprazole) can weaken your bones and increase your risk of getting bone fractures especially in the hip, wrist, or back. The chances of this happening are higher if you take the medicine for 1 year or longer. Use Protonix (pantoprazole) at the lowest dose and for the shortest amount of time possible.

Common concerns from people taking Protonix (pantoprazole)

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  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
Kidneys and liver
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.