Prescription onlyLower-cost generic availableClass: Neuro/psych

Parnate

(tranylcypromine)

Prescription onlyLower-cost generic availableClass: Neuro/psych
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Stabilizes your mood.

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Our bottom line

Parnate (tranylcypromine) is not a first choice medicine to treat depression because of its side effects and interactions with other medicines and foods.

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Upsides

  • If other medicines haven't worked to help your depression, Parnate (tranylcypromine) can be a good alternative.
  • Parnate (tranylcypromine) doesn't cause weight gain.
  • Parnate (tranylcypromine) doesn't make you feel sleepy.
  • Parnate (tranylcypromine) is available as generic.

Downsides

  • You have to take Parnate (tranylcypromine) 2 to 3 times a day, which can be inconvenient.
  • If you take Parnate (tranylcypromine) any later than early afternoon, you might have problems sleeping.
  • Not recommended in children under 18 years of age.
How it works

Parnate (tranylcypromine) is a monoamine oxidase inhibitor. It increases the amount of norepinephrine, dopamine, and serotonin in your body which are believed to regulate mood.

What to expect when you take Parnate (tranylcypromine) for Depression

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Side effect rates for Parnate (tranylcypromine)

Risks and Warnings for Parnate (tranylcypromine)

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    • Higher risk if:
    • People under age 24

    Taking Parnate (tranylcypromine) can make you more likely to harm yourself or commit suicide, especially if you are younger and during the first few weeks of taking the medicine. If you or your child feel like they want to hurt themselves while taking Parnate (tranylcypromine), call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Parnate (tranylcypromine)

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Pregnancy
Interactions
  • Parnate (tranylcypromine) interacts with many medicines that can make you more likely to have side effects, so you'll want to tell your doctor and pharmacist what else you're taking, even the supplements and over-the-counter medicines. Your doctor might have to change how you take your medicines so that you don't get side effects.
Alcohol
  • Avoid alcohol and limit the amount of caffeine you take if you take Parnate (tranylcypromine).
  • Eating certain foods or drinking beer or wine while taking Parnate (tranylcypromine) can cause your blood pressure to become dangerously high. Talk to your doctor or go to the emergency room right away if you get a very bad headache, changes in your heart rate, neck stiffness or soreness, or nausea and vomiting.
Food
  • Eating certain foods or drinking beer or wine while taking Parnate (tranylcypromine) can cause your blood pressure to become dangerously high. Talk to your doctor or go to the emergency room right away if you get a very bad headache, changes in your heart rate, neck stiffness or soreness, or nausea and vomiting.
Weight
  • Parnate (tranylcypromine) doesn't cause weight gain.