Prescription onlyLower-cost generic availableClass: Mental health

Paxil Alternatives

(Paroxetine)

Prescription onlyLower-cost generic availableClass: Mental health
Back to: Full Site Navigation

Compare Paxil (Paroxetine) to alternatives

These medications are comparable to Paxil (Paroxetine) or used for similar purposes.

Paxil
(Paroxetine)

Cymbalta
(Duloxetine)

Wellbutrin
(Bupropion)

Celexa
(Citalopram)

Zoloft
(Sertraline)

Remeron
(Mirtazapine)

Oleptro
(Trazodone)

Lexapro
(Escitalopram)

Prozac
(Fluoxetine)

Effexor
(Venlafaxine)

Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.Improves mood. Wellbutrin (Bupropion) is good for treating depression and has fewer sexual side effects than other antidepressants, but you need to be okay with avoiding alcohol.Improves mood and helps you relax. Celexa (Citalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Zoloft (Sertraline) is good for treating depression and anxiety. It's more likely to cause insomnia and diarrhea than other antidepressants.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.Improves mood and helps you relax. Lexapro (Escitalopram) is good for treating depression and anxiety. Might be less likely to cause side effects than some antidepressants, but not the best choice for people with heart or liver problems.Improves mood and helps you relax. Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.Improves mood and helps you relax. Effexor (Venlafaxine) is good for treating depression and anxiety. May work when other antidepressants haven't, it's but more likely to cause side effects and withdrawal symptoms than other antidepressants.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Paxil
Reviews for Paxil (Paroxetine)
52%
of people (All ages) say Paxil (Paroxetine) is worth it
39%
say it works well
24%
say it's a big hassle
694 reviews
Have you used Paxil (Paroxetine)?
Worth itNot sureNot worth it
Reviews for Cymbalta (Duloxetine)
58%
+6% better vs. Paxil (Paroxetine)
49%
+10% better vs. Paxil (Paroxetine)
24%
Same vs. Paxil (Paroxetine)
496 reviews
Have you used Cymbalta (Duloxetine)?
Worth itNot sureNot worth it
Reviews for Wellbutrin (Bupropion)
60%
+8% better vs. Paxil (Paroxetine)
40%
+1% better vs. Paxil (Paroxetine)
13%
+11% better vs. Paxil (Paroxetine)
1164 reviews
Have you used Wellbutrin (Bupropion)?
Worth itNot sureNot worth it
Reviews for Celexa (Citalopram)
61%
+9% better vs. Paxil (Paroxetine)
51%
+12% better vs. Paxil (Paroxetine)
16%
+8% better vs. Paxil (Paroxetine)
520 reviews
Have you used Celexa (Citalopram)?
Worth itNot sureNot worth it
Reviews for Zoloft (Sertraline)
59%
+7% better vs. Paxil (Paroxetine)
41%
+2% better vs. Paxil (Paroxetine)
15%
+9% better vs. Paxil (Paroxetine)
1472 reviews
Have you used Zoloft (Sertraline)?
Worth itNot sureNot worth it
Reviews for Remeron (Mirtazapine)
45%
-7% worse vs. Paxil (Paroxetine)
39%
Same vs. Paxil (Paroxetine)
26%
-2% worse vs. Paxil (Paroxetine)
152 reviews
Have you used Remeron (Mirtazapine)?
Worth itNot sureNot worth it
Reviews for Oleptro (Trazodone)
73%
+21% better vs. Paxil (Paroxetine)
49%
+10% better vs. Paxil (Paroxetine)
24%
Same vs. Paxil (Paroxetine)
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Reviews for Lexapro (Escitalopram)
61%
+9% better vs. Paxil (Paroxetine)
48%
+9% better vs. Paxil (Paroxetine)
15%
+9% better vs. Paxil (Paroxetine)
1063 reviews
Have you used Lexapro (Escitalopram)?
Worth itNot sureNot worth it
Reviews for Prozac (Fluoxetine)
62%
+10% better vs. Paxil (Paroxetine)
40%
+1% better vs. Paxil (Paroxetine)
16%
+8% better vs. Paxil (Paroxetine)
1319 reviews
Have you used Prozac (Fluoxetine)?
Worth itNot sureNot worth it
Reviews for Effexor (Venlafaxine)
62%
+10% better vs. Paxil (Paroxetine)
51%
+12% better vs. Paxil (Paroxetine)
23%
+1% better vs. Paxil (Paroxetine)
577 reviews
Have you used Effexor (Venlafaxine)?
Worth itNot sureNot worth it
Side effects
PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
  • Nausea 17%
  • Drowsiness 14%
  • Dry mouth 6%
  • Headache 1%
  • Muscle weakness 9%
  • Constipation 5%
  • Sleep difficulty 7%
  • Ejaculatory disturbance‡§ 13%
  • Dizziness 7%
  • Diarrhea 4%
More Paxil side effects »
  • Nausea 15%
  • Headache 2%
  • Dry mouth 8%
  • Somnolencee 7%
  • Fatigue 4%
  • Sleep difficulty 4%
  • Constipation 5%
  • Dizziness 4%
  • Diarrhea 3%
  • Decreased appetite 5%
More Cymbalta side effects »
  • Agitation 10%
  • Dry mouth 10%
  • Headache/migraine 4%
  • Constipation 9%
  • Nausea/vomiting 4%
  • Excessive sweating 7%
  • Dizziness 6%
  • Tremor 13%
  • Sleep difficulty 3%
More Wellbutrin side effects »
  • Nausea 7%
  • Dry mouth 6%
  • Drowsiness 8%
  • Sleep difficulty 1%
  • Sweating increased 2%
  • Diarrhea 3%
  • Tremor 2%
  • Ejaculation disorder 5%
  • Inflammation inside the nose 1%
  • Indigestion 1%
More Celexa side effects »
  • Nausea 10%
  • Diarrhea/loose stools 6%
  • Sleep difficulty 2%
  • Mouth dry 7%
  • Fatigue 10%
  • Dizziness 2%
  • Feeling unwell 2%
  • Indigestion 4%
  • Loss of appetite 5%
  • Lower sex drive 2%
More Zoloft side effects »
  • Drowsiness 36%
  • Dry mouth 10%
  • Increased appetite 15%
  • Constipation 6%
  • Weight gain 10%
  • Muscle weakness 3%
  • Dizziness 4%
  • Flu syndrome 2%
  • Abnormal dreams 3%
  • Thinking abnormal 2%
More Remeron side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
  • Nausea 8%
  • Ejaculation disorder 9%
  • Sleep difficulty 5%
  • Diarrhea 3%
  • Dry mouth 1%
  • Drowsiness 4%
  • Inflammation inside the nose 1%
  • Dizziness 2%
  • Flu-like symptomsa-like symptoms 1%
  • Sweating increased 3%
More Lexapro side effects »
  • Nausea 13%
  • Headache 2%
  • Sleep difficulty 18%
  • Nervousness 5%
  • Drowsiness 7%
  • Anxiety 6%
  • Diarrhea 4%
  • Muscle weakness 5%
  • Loss of appetite 7%
  • Dizziness 3%
More Prozac side effects »
  • Nausea 24%
  • Dizziness 19%
  • Sleep difficulty 10%
  • Drowsiness 14%
  • Muscle weakness 12%
  • Loss of appetite 12%
  • Nervousness 10%
  • Sweating 7%
  • Abnormality of accommodation 8%
  • Indigestion 5%
More Effexor side effects »
How it works
PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.Wellbutrin (Bupropion) is an atypical antidepressant. Researchers don't know exactly how it works, but it seems to change dopamine and norepinephrine activity in the brain, which regulate mood.Celexa (Citalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases the activity of serotonin in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Lexapro (Escitalopram) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Effexor (Venlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulate mood.
Type of medication
PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
  • Pill
  • Extended release tablet
  • Liquid
  • Extended release
  • Pill
  • Extended release
  • Pill
  • Oral solution
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
  • Pill
  • Extended release
  • Pill
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
  • Pill
  • Extended release
Used for
PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
Risk factors for serious side effects
PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
      Detailed Paxil (Paroxetine) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • Stopping Cymbalta (Duloxetine) suddenly
      • History of high blood pressure
      • Taking other blood-thinning drugs
        • History of bipolar disorder
        • At risk for bipolar disorder
        Detailed Cymbalta (Duloxetine) risks & warnings »
        • Age 24 years or younger
        • History of depression
        • History of bipolar disorder
        • At risk for bipolar disorder
        • Withdrawing from nicotine
        • History of seizures
        • Alcoholism
        • Eating disorder
        • Higher dose
        • Drug interactions
        • History of bipolar disorder
        • At risk for bipolar disorder
        • Current kidney problems
        • Current liver problems
          Detailed Wellbutrin (Bupropion) risks & warnings »
          • Age 24 years or younger
          • Using other medications that affect serotonin
          • History of bipolar disorder
          • At risk for bipolar disorder
          • Stopping Celexa (Citalopram) suddenly
          • Higher dose
          • History of heart problems
          • History of liver problems
          • Older age
          • Taking other blood-thinning drugs
            Detailed Celexa (Citalopram) risks & warnings »
            • Under 24 years old
            • Interactions with other medications
                • Stopping Zoloft (Sertraline) suddenly
                • Taking with blood-thinning drugs
                • Elderly
                • Taking with diuretic medications
                Detailed Zoloft (Sertraline) risks & warnings »
                • Age 24 years or younger
                • Using other medications that affect serotonin
                • History of heart problems
                • History of liver problems
                • Higher dose
                • Alcohol
                • Taking other medicines that make you less alert
                    Detailed Remeron (Mirtazapine) risks & warnings »
                    • Age 24 years or younger
                    • History of seizures
                    • Alcoholism
                    • Eating disorder
                    • Higher dose
                    • Drug interactions
                      • Age 65 years or older
                      • Alcohol
                      • Taking other medicines that make you less alert
                      Detailed Oleptro (Trazodone) risks & warnings »
                      • Age 24 years or younger
                      • Using other medications that affect serotonin
                      • Stopping Lexapro (Escitalopram) suddenly
                      • Higher dose
                      • History of heart problems
                      • History of liver problems
                      • Taking other blood-thinning drugs
                        • History of bipolar disorder
                        • At risk for bipolar disorder
                        Detailed Lexapro (Escitalopram) risks & warnings »
                        • Age 24 years or younger
                        • Using other medications that affect serotonin
                        • Stopping Prozac (Fluoxetine) suddenly
                        • History of heart problems
                        • History of liver problems
                        • Drug interactions
                        • Taking other blood-thinning drugs
                          • History of bipolar disorder
                          • At risk for bipolar disorder
                          Detailed Prozac (Fluoxetine) risks & warnings »
                          • Age 24 years or younger
                          • Using other medications that affect serotonin
                          • Stopping Effexor (Venlafaxine) suddenly
                          • History of high blood pressure
                          • Taking other blood-thinning drugs
                            • History of bipolar disorder
                            • At risk for bipolar disorder
                            Detailed Effexor (Venlafaxine) risks & warnings »
                            Pregnancy

                            Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

                            Interactions
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                            • It interacts with St. John's Wort and Tryptophan.
                            No interactions related info.No interactions related info.No interactions related info.No interactions related info.No interactions related info.
                            Alcohol
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            No alcohol related info.No alcohol related info.
                            • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
                            No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
                            Food
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            • Take with food to avoid upset stomach.
                            • Take with food to avoid upset stomach.
                            No food related info.
                            • Take with food to avoid upset stomach.
                            No food related info.No food related info.No food related info.
                            • Take with food to avoid upset stomach.
                            • Take in the morning with food to avoid side effects.
                            No food related info.
                            Kidneys and liver
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            No kidneys and liver related info.
                            • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
                            • Wellbutrin (Bupropion) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent increased risk for side effects.
                            • Not a good option for you if you have heart or liver problems.
                            No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
                            • Not a good option for you if you have heart or liver problems.
                            No kidneys and liver related info.No kidneys and liver related info.
                            Pain
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            No pain related info.
                            • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
                            No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.No pain related info.
                            Sex
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            No sex related info.No sex related info.No sex related info.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            No sex related info.No sex related info.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            Sleep
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            • It causes drowsiness, so it's good for people who have trouble sleeping.
                            No sleep related info.No sleep related info.No sleep related info.
                            • Causes less drowsiness than other antidepressants.
                            • Zoloft (Sertraline) may increase the risk of low sodium levels in the blood (hyponatremia). Watch out for symptoms including headache, difficulty concentrating, memory problems, confusion, weakness, and unsteadiness, which may lead to falls. Talk to a doctor right away before developing more serious symptoms, such as hallucination, fainting, coma, and death.
                            No sleep related info.No sleep related info.No sleep related info.No sleep related info.No sleep related info.
                            Weight
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
                            • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
                            No weight related info.
                            • It's less likely to cause weight gain than other antidepressants.
                            • Can cause minor weight gain (1 to 5 pounds).
                            No weight related info.
                            • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
                            • Can increase appetite and weight.
                            • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
                            No weight related info.
                            • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
                            No weight related info.No weight related info.
                            Upsides and benefits
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            • Effective at relieving depression and anxiety symptoms.
                            • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
                            • It causes drowsiness, so it's good for people who have trouble sleeping.
                            • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at relieving depression and anxiety symptoms.
                            • Lowers relapse rates for depression.
                            • Can relieve some types of chronic pain. Might be particularly good at pain relief for people who are also depressed.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at relieving depression symptoms.
                            • Causes fewer sexual side effects than other antidepressants. Can actually boost sex drive for some people.
                            • Can be taken with other antidepressants to counteract their sexual side effects.
                            • Has some stimulant effects, so it can be energizing.
                            • Can help with ADHD symptoms.
                            • Also used to suppress appetite and help you quit smoking.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at relieving depression and anxiety symptoms.
                            • Causes less sleepiness compared to other antidepressants.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at lowering symptoms and relapse rates of depression and anxiety disorders.
                            • Causes less drowsiness than other antidepressants.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at relieving some depression symptoms.
                            • Starts to work more quickly than most antidepressants.
                            • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
                            • Good option for people who are underweight or frail, because it can help you gain weight.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Commonly used in lower doses to help treat sleep problems (insomnia).
                            • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
                            • Fewer sexual side effects than many other antidepressants.
                            • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
                            • Comes as a generic medication and is cheaper than many other sleep aides.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at relieving depression and anxiety symptoms.
                            • Lowers relapse rates of depression.
                            • Causes less sleepiness than some other antidepressants.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at relieving depression and anxiety symptoms.
                            • Lowers relapse rates of depression and bulimia nervosa.
                            • Causes less sleepiness than other antidepressants.
                            • It's more energizing than other antidepressants, so it's good for people who have low energy.
                            • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Effective at relieving depression and anxiety symptoms.
                            • Lowers relapse rates of depression.
                            • Causes more sleepiness than other antidepressants, so it's good for people who have trouble sleeping.
                            • Six out of ten people who use an antidepressant for the first time find that it works for them.
                            • Might work when other antidepressants haven't worked since it affects two chemicals in the brain that impact your mood. Many other antidepressants affect only serotonin, but not norepinephrine too.
                            Downsides and risks
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
                            • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
                            • Can harm an unborn child, so you can't take it if you're pregnant.
                            • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Not a good option if you're a heavy drinker, or if you have liver or kidney problems.
                            • Not the best option for people with high blood pressure.
                            • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Wellbutrin (Bupropion) can be stimulating, so it can cause anxiety or insomnia the first few days you're taking it.
                            • Generally not as good as other antidepressants for people who have anxiety.
                            • It's less likely to cause weight gain than other antidepressants.
                            • Has a higher risk of causing seizures, especially if you have a seizure disorder, eating disorder, or if you drink alcohol. So, it's not a good medication if you drink a lot.
                            • It contains the same ingredient as a medication that helps you to stop smoking, (Zyban), so these two meds can't be used together.
                            • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • Can cause minor weight gain (1 to 5 pounds).
                            • Celexa (Citalopram) can cause an irregular heartbeat if you take a high dose (40 mg a day, or more).
                            • Not a good option for you if you have heart or liver problems.
                            • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24 years.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • More likely to cause diarrhea than other antidepressants.
                            • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Not as effective as other medications for depression.
                            • More sedating than other antidepressants.
                            • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
                            • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Not as effective as other medications for depression.
                            • More sedating than other antidepressants.
                            • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
                            • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • More likely to cause minor weight gain (1 to 5 pounds) than other antidepressants.
                            • Can cause an irregular heartbeat if you take a high dose (20 mg a day, or more).
                            • Not a good option for you if you have heart or liver problems.
                            • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                            • The first antidepressant you try doesn't always work, and might have side effects you really don't like. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
                            • More likely than other antidepressants to interact with other medications you're taking.
                            • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
                            • Not the best option for people with high blood pressure.
                            • Overdosing on this medication could be fatal.
                            • It's more likely to cause nausea and vomiting or make you feel sick if you miss a dose than other antidepressants. Also causes more sleepiness than others.
                            • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
                            • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
                            Tips from our pharmacists for people taking the medication
                            PaxilCymbaltaWellbutrinCelexaZoloftRemeronOleptroLexaproProzacEffexor
                            • Take with food to avoid upset stomach.
                            • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                            • Stop taking it slowly to avoid getting withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • The controlled-release (CR) tablet can cause less nausea than other forms.
                            • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
                            • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
                            • Take with food to avoid upset stomach.
                            • Full effects in 8 to 12 weeks for mood, 2 weeks for pain.
                            • Stop taking slowly to avoid withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • Wellbutrin (Bupropion) makes you energized, so take it in the morning to avoid difficulty sleeping later that night.
                            • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                            • There are no sexual side effects from this medication.
                            • Stop taking it slowly to avoid getting withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • The extended-release tablet shell can show up unchanged in your stool, but don't worry since the medication was still absorbed by your body.
                            • Take with food to avoid upset stomach.
                            • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                            • Stop taking it slowly to avoid getting withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                            • It interacts with St. John's Wort and Tryptophan.
                            • Stop taking it slowly to avoid getting withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • Makes you sleepy. Take at bedtime.
                            • Can increase appetite and weight.
                            • Takes 8 to 12 weeks to see full effects on mood.
                            • Stop taking slowly to avoid withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • Makes you sleepy. Take at bedtime.
                            • Can cause temporary dry mouth and upset stomach.
                            • Seek medical attention for unwanted, persistent erection.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • Take with food to avoid upset stomach.
                            • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                            • Stop taking it slowly to avoid getting withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • Take in the morning with food to avoid side effects.
                            • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                            • Stop taking it slowly to avoid getting withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
                            • You can take the extended-release form once a day with food either in the morning or in the evening at about the same time each day.
                            • Extended-release capsules should be swallowed whole. If you can’t swallow pills, open the capsule, sprinkle it on a spoonful of applesauce and then swallow it without chewing.
                            • Stop taking it slowly to avoid getting withdrawal symptoms.
                            • Tell your doctor if you notice sudden mood changes or unusual thoughts.
                            Learn more
                            More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert
                            Have you used Paxil (Paroxetine)?
                            Worth itNot sureNot worth it
                            More about CymbaltaSide effectsReviews & ratingsFDA package insert
                            Have you used Cymbalta (Duloxetine)?
                            Worth itNot sureNot worth it
                            More about WellbutrinSide effectsReviews & ratingsFDA package insert
                            Have you used Wellbutrin (Bupropion)?
                            Worth itNot sureNot worth it
                            More about CelexaSide effectsReviews & ratingsFDA package insert
                            Have you used Celexa (Citalopram)?
                            Worth itNot sureNot worth it
                            More about ZoloftSide effectsReviews & ratingsFDA package insert
                            Have you used Zoloft (Sertraline)?
                            Worth itNot sureNot worth it
                            More about RemeronSide effectsReviews & ratingsFDA package insert
                            Have you used Remeron (Mirtazapine)?
                            Worth itNot sureNot worth it
                            More about OleptroSide effectsReviews & ratingsFDA package insert
                            Have you used Oleptro (Trazodone)?
                            Worth itNot sureNot worth it
                            More about LexaproSide effectsReviews & ratingsFDA package insert
                            Have you used Lexapro (Escitalopram)?
                            Worth itNot sureNot worth it
                            More about ProzacSide effectsReviews & ratingsFDA package insert
                            Have you used Prozac (Fluoxetine)?
                            Worth itNot sureNot worth it
                            More about EffexorSide effectsReviews & ratingsFDA package insert
                            Have you used Effexor (Venlafaxine)?
                            Worth itNot sureNot worth it