Prescription onlyLower-cost generic availableClass: Pain

Percocet 

(oxycodone / acetaminophen)

Prescription onlyLower-cost generic availableClass: Pain
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Treats moderate to severe pain.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Price and discounts
Prices and coupons for 120 (5mg/325mg) tablets of oxycodone / acetaminophen

Upsides

  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
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1399 reviews

Downsides

  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
How it works

Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.

What to expect when you take Percocet (oxycodone / acetaminophen) for Pain

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Side effect rates for Percocet (oxycodone / acetaminophen)

Risks and Warnings for Percocet (oxycodone / acetaminophen)

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    • Higher risk if:
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen

    The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Percocet (oxycodone / acetaminophen)

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Pregnancy
Alcohol
  • Avoid alcohol.
  • I equate the repercussions of taking a percocet to drinking a six-pack of beer, in that I feel similar hang-over effects when I don't take one the next day.
Food
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
  • Don't take more than instructed to prevent liver damage.
  • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
Pain
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Take 2 a day for chronic pain. Takes the edge off and I thank God for it. Never increased my dosage. once I n awhile 3 5/325 followed by one the next.
  • Used for breakthrough pain, don't wait till pain gets bad, take immediately
  • It's a hassle to see a pain specialist every month and it costs a lot of money. I have to pay the pain specialist $150 per visit plus the medication is expensive. It does help immensely though.
Sleep
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
  • It will make you sleepy