Prescription onlyLower-cost generic available


(Oxycodone / Acetaminophen)

  • Pill
  • Oral solution
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Treats moderate to severe pain.

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Prescription onlyLower-cost generic available

Our bottom line

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.


  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
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  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.

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What to expect when you take Percocet (Oxycodone / Acetaminophen) for Pain

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Tips from our pharmacists
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Starts working in 30 minutes.
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Can make you dizzy or drowsy.
  • Avoid activities need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
  • Don't take more than instructed to prevent liver damage.
  • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
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Side effects for Percocet (Oxycodone / Acetaminophen)

Manufacturers don’t say how common these side effects are

  • Abnormally slow breathing
  • Agranulocytosis
  • Circulatory depression
  • Dizziness
  • Drowsiness or sedation
  • Erythematous skin reactions
  • Hematologic reactions
  • Hypoglyemic coma
  • Life-threatening lack of blood flow
  • Lightheadedness
  • Low blood pressure
  • Nausea
  • Renal tubular necrosis
  • Respiratory arrest
  • Skin eruptions
  • Stopped breathing
  • Urticarial
  • Vomiting

Risks and Warnings for Percocet (Oxycodone / Acetaminophen)

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    • Higher risk if:
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen

    The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Percocet (Oxycodone / Acetaminophen)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Upsides and downsides from our pharmacists
  • Avoid alcohol.
  • Risks from our pharmacists
  • Even 1 dose of an extended-release tablet can be too much for a child so store out of reach from children. In adults, raising the dose too quickly, high doses or mixing with alcohol or drugs that interact causes overdose and death. If you suspect a child has taken Percocet (Oxycodone / Acetaminophen), or an adult has taken too much, watch them for decreased activity, extreme tiredness small pupils, and lips and fingers turning blue from low oxygen. Call 911 or go to a hospital immediately. Doctors can give a medicine that reverses the effects of Percocet (Oxycodone / Acetaminophen).
  • I equate the repercussions of taking a percocet to drinking a six-pack of beer, in that I feel similar hang-over effects when I don't take one the next day.
  • Tips from our pharmacists
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
  • Try not to take Percocet every day if at all possible. I find that when I don't take any for a few days, the next time it is more effective/potent for relief from kidney stone pain. Hint: Drink grapefruit juice with it.
  • Upsides and downsides from our pharmacists
  • Dizziness and drowsiness is common, but your body may adjust.
  • Tips from our pharmacists
  • Can make you dizzy or drowsy.
  • dont take it in the day it will make you drowsy
  • Risks from our pharmacists
  • Oxycodone, one of the medications in Percocet (Oxycodone / Acetaminophen) passes into breast milk. Women with a history of long-term opioid use increase the risk of neonatal withdrawal syndrome. Symptoms in the newborn include irritability, vomiting, diarrhea, tremor and lack of weight gain. Opioid withdrawal in infants can be a life-threatening emergency and needs immediate medical care.