Percocet

(Oxycodone / Acetaminophen)

3.8/ 5 average rating with 1399 reviewsforPercocet
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Treats moderate to severe pain.

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Prescription opioids are used to treat several kinds of pain - but they carry significant risks, including addiction. Learn more about these drugs and be sure to discuss the risks with your doctor.

Our bottom line

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

Quick facts about Percocet
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (oxycodone / acetaminophen)
Prices and discounts
Lowest price for 120 5mg-325mg tablets
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$24.06
  • Price before coupon
    $33.82
  • Lowest price with coupon
    $24.06
  • Savings
    29%

Upsides

  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.

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What to expect from Percocet, on one page

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People’s experience with Percocet

1399reviews so far. What do you think?

Downsides

  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.

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Get our free fact sheet

What to expect from Percocet, on one page

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Prices and discounts
Lowest price for 120 5mg-325mg tablets
Determining your location...
$24.06
  • Price before coupon
    $33.82
  • Lowest price with coupon
    $24.06
  • Savings
    29%
How it works

Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.

Quick facts about Percocet
  • Drug class: Pain
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (oxycodone / acetaminophen)

Dosage forms

  • Pill
  • Oral solution
People’s experience with Percocet

1399reviews so far. What do you think?

What to expect when you take Percocet (Oxycodone / Acetaminophen) for Pain

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Skip side effects section. Skip to risks and warnings section.

Side effect rates for Percocet (Oxycodone / Acetaminophen)

Risks and Warnings for Percocet (Oxycodone / Acetaminophen)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Current liver disease
    • Taking with alcohol
    • Taking other medicines with acetaminophen

    The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Percocet (Oxycodone / Acetaminophen)

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Pregnancy
Alcohol
  • Avoid alcohol.
  • Reviewed Percoceton 10/27/2016I equate the repercussions of taking a percocet to drinking a six-pack of beer, in that I feel similar hang-over effects when I don't take one the next day.
    26
    Man
    Pain (moderate to moderately-severe)
Food
  • Take it with food to lower the chance of an upset stomach.
Kidneys and liver
  • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
  • Don't take more than instructed to prevent liver damage.
Pain
  • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
  • Works best if you take it as soon as you start feeling pain.
  • Pain relief lasts 4-6 hours.
  • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Reviewed Percocet Used for breakthrough pain, don't wait till pain gets bad, take immediately
    56
    Woman
  • Reviewed Percoceton 9/15/2016It's a hassle to see a pain specialist every month and it costs a lot of money. I have to pay the pain specialist $150 per visit plus the medication is expensive. It does help immensely though.
    36
    Man
    Pain (moderate to moderately-severe)
  • Reviewed Percoceton 6/30/2017I take this for severe back pain. I've been on it for a few years. It will make me hyper, so I make sure to take my last one of the day by the latest 5:30pm. Withdraw is extremely hard. I had almost a week without it when my doc was on vacation and it was horrible. Overall, I'm so thankful for this medication.
    34
    Woman
    Two years or more
    Pain (moderate to moderately-severe)
Sleep
  • Can help you fall asleep easier.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Reviewed Percoceton 10/26/2016It will make you sleepy
    55
    Woman
    Pain (moderate to moderately-severe)