Prescription onlyLower-cost generic availableClass: Neuro/psych



Prescription onlyLower-cost generic availableClass: Neuro/psych
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Treats schizophrenia.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.

Price and discounts
Best available price for 30 (4mg) tablets of perphenazine
What is GoodRx?


  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.


  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
How it works

Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.

What to expect when you take Trilafon (perphenazine) for Schizophrenia

Skip what to expect section. Skip to Risks & Warnings section.
Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Trilafon (perphenazine)

Risks and Warnings for Trilafon (perphenazine)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • People age 65 or older with dementia and psychosis

    Older people who have dementia and psychosis have a higher risk of death if they take antipsychotic medicines like Trilafon (perphenazine). They shouldn't be given this medicine.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Trilafon (perphenazine)

Final section. Do you want to return to drug navigation?
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
  • You're more likely to gain weight.