Prescription onlyLower-cost generic available



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Helps you feel less queasy.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.

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  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.

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Side effects for Phenergan (Promethazine)

Manufacturers don’t say how common these side effects are

  • Abnormal movements
  • Abnormally fast heart beat
  • Abnormally slow breathing
  • Abnormally slow heartbeat
  • Abscesses
  • Agitated behaivor
  • Agranulocytosis
  • Angioneurotic edema
  • Asthma
  • Blood clot in a vein
  • Blurred vision
  • Burning
  • Catatonic-like states
  • Confusion
  • Convulsive seizures
  • Decreased blood pressure
  • Delirium
  • Diploplia
  • Disorientation
  • Dizziness
  • Drowsiness
  • Drowsiness
  • Dry mouth
  • Euphoria
  • Excessive bruising or bleeding
  • Excitation
  • Extrapyramidal symptoms
  • Faintness
  • Fatigue
  • Gangrene
  • Hallucations
  • Hives
  • Hyperexcitability
  • Inability to move
  • Incoordination
  • Increased blood pressure
  • Lack of energy
  • Life-threatening fever and muscle rigidity
  • Low white blood cells
  • Nasal stuffiness
  • Nausea
  • Nervousness
  • Nightmares
  • Pain
  • Paralysis with tremors
  • Rash
  • Redness
  • Relaxation or sleepiness
  • Ringing in the ears
  • Sensitivity to light
  • Sensory loss
  • Severe spasm of distal vessels
  • Sleep difficulty
  • Stopped breathing
  • Superficial leg vein clots
  • Swelling
  • Thrombocytopenia
  • Thrombophlebitis
  • Tissue death
  • Tremors
  • Uncontrollable emotion
  • Vomiting
  • Yellow skin or eyes

What to expect when you take Phenergan (Promethazine)

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Tips from our pharmacists
  • Promethazine comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
  • Don't give to kids 2 and under.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
  • Avoid using if you experience seizures (epilepsy).
  • Don't use if you're 65 or older because you're at higher risk for serious side effects.

Risks and Warnings for Phenergan (Promethazine)

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    • Higher risk if:
    • Children under 2 years of age

    It's not recommended for children and teenagers, especially under the age of 2, to take Phenergan (Promethazine). There are reports of children whose breathing has slowed down after taking Phenergan (Promethazine), and some have died, especially if they were taking other medications that also slow down breathing.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Phenergan (Promethazine)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Upsides and downsides from our pharmacists
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Tips from our pharmacists
  • Don't drink alcohol to avoid intense side effects.
  • It works well but it's downside is the drowsiness. If you need the sleep, then I would recommend this. Zofran does very little for me.
    Age: 33
    Gender: Woman
    Taken for: Nausea and vomiting
  • Very cheap and works way better than OTC remedies as motion sickness preventative - take before departure. Can technically be used as backup/additive to transdermal scopolamine, tho might increase drowsiness and dry mouth.
    Age: 55
    Gender: Woman
    Taken for: Motion sickness
  • I take this as required for a sleep aid. I like how mild they are & really relax me to the point I drift off instead of being knocked out by a benzo. Also really help with nausea, wish I'd known about these sooner! Absolutely eradicate hangovers too!
    Age: 21
    Gender: Woman
    Taken for: Sedation