Prescription onlyLower-cost generic availableClass: Gastrointestinal



Prescription onlyLower-cost generic availableClass: Gastrointestinal
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Helps you feel less queasy.

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Our bottom line

Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.

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Prices and coupons for 20 (25mg) tablets of promethazine


  • Available in generic.
  • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
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  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
  • Can make your skin more sensitive to the sun.
How it works

Phenergan (Promethazine) is an antihistamine, which helps control allergies. It also seems to block your body's natural reflex for vomiting, which makes it useful as an antiemetic (anti-nausea medicine).

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Side effect rates for Phenergan (promethazine)

Risks and Warnings for Phenergan (promethazine)

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    • Higher risk if:
    • Children under 2 years of age

    It's not recommended for children and teenagers, especially under the age of 2, to take Phenergan (Promethazine). There are reports of children whose breathing has slowed down after taking Phenergan (Promethazine), and some have died, especially if they were taking other medications that also slow down breathing.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Phenergan (promethazine)

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  • Don't drink alcohol to avoid intense side effects.
  • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
  • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
  • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
  • Very cheap and works way better than OTC remedies as motion sickness preventative - take before departure. Can technically be used as backup/additive to transdermal scopolamine, tho might increase drowsiness and dry mouth.
  • It works well but it's downside is the drowsiness. If you need the sleep, then I would recommend this. Zofran does very little for me.