Prescription onlyLower-cost generic availableClass: Gastrointestinal

Phenergan Alternatives

(Promethazine)

Prescription onlyLower-cost generic availableClass: Gastrointestinal
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Compare Phenergan (Promethazine) to alternatives

These medications are comparable to Phenergan (Promethazine) or used for similar purposes.

Phenergan
(Promethazine)

Zofran
(Ondansetron)

Transderm-Scop
(Scopolamine)

Compro
(Prochlorperazine)

Helps you feel less queasy. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.Helps you feel less queasy. Zofran (Ondansetron) works well to prevent nausea and vomiting, and it's available in different forms that you don't have to swallow.Helps you feel less queasy. Transderm-Scop (Scopolamine) works well to prevent nausea and vomiting and the patch is low-hassle, but it takes about 4 hours to kick in.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.
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Reviews & ratings
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6.08Phenergan
Reviews for Phenergan (Promethazine)
82%
of people (All ages) say Phenergan (Promethazine) is worth it
76%
say it works well
5%
say it's a big hassle
Have you used Phenergan (Promethazine)?
Worth itNot sureNot worth it
Reviews for Zofran (Ondansetron)
66%
-16% worse vs. Phenergan (Promethazine)
51%
-25% worse vs. Phenergan (Promethazine)
15%
-10% worse vs. Phenergan (Promethazine)
366 reviews
Have you used Zofran (Ondansetron)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Transderm-Scop (Scopolamine)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Compro (Prochlorperazine)?
Worth itNot sureNot worth it
Side effects
PhenerganZofranScopolamineCompro

The Phenergan FDA package insert doesn’t have numbers about how common side effects are.

More about Phenergan side effects »
  • Headache 2%
  • Constipation 11%
  • Fever 5%
  • Increased ast and alt 5%
  • Drowsiness 4%
  • Itching 2%
  • Tingling sensation 2%
More Zofran side effects »
  • Dry mouth 66%
  • Dizziness 17%
  • Any side effect 10%
  • Drowsiness 4%
  • Agitation 2%
  • Visual impairment 2%
  • Confusion 1%
  • Dilated pupil 4%
  • Sore throat 1%
More Scopolamine side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »
How it works
PhenerganZofranScopolamineCompro
Phenergan (Promethazine) is an antihistamine, which helps control allergies. It also seems to block your body's natural reflex for vomiting, which makes it useful as an antiemetic (anti-nausea medicine).Zofran (Ondansetron) is an antiemetic (anti-nausea medicine). It works by blocking the nerves that cause your nausea and vomiting reflex.Transderm-Scop (Scopolamine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.
Type of medication
PhenerganZofranScopolamineCompro
Prescription only
Prescription only
Prescription only
Prescription only
Available as
PhenerganZofranScopolamineCompro
  • Pill
  • Liquid
  • Suppository
  • Pill
  • Dissolving tablet
  • Liquid
  • Sublingual film
  • Patch
  • Pill
  • Suppository
Used for
PhenerganZofranScopolamineCompro
Risk factors for serious side effects
PhenerganZofranScopolamineCompro
  • Children under 2 years of age
  • History of seizures
    • Age over 65
      Detailed Phenergan (Promethazine) risks & warnings »
        • Long QT syndrome
        Detailed Zofran (Ondansetron) risks & warnings »
        • Glaucoma
          • Doing an MRI
          • History of seizures
          • History of psychosis
          • Taking with alcohol
          • Taking other medicines that make you less alert
          Detailed Transderm-Scop (Scopolamine) risks & warnings »
          • Over age 65
          • Dementia
          • Taking antipsychotics
          • History of seizures
          • Age over 65
              • Taking with alcohol
              • Taking other medicines that make you less alert
              Detailed Compro (Prochlorperazine) risks & warnings »
              Pregnancy

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

              Interactions
              PhenerganZofranScopolamineCompro
              No interactions related info.
              • Can interact with antidepressants.
              No interactions related info.No interactions related info.
              Alcohol
              PhenerganZofranScopolamineCompro
              • Don't drink alcohol to avoid intense side effects.
              No alcohol related info.
              • You have to avoid alcohol while on the medication.
              • Don't drink alcohol if you have to use the patch.
              • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
              • Don't drink alcohol to avoid intense side effects.
              Pain
              PhenerganZofranScopolamineCompro
              • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
              No pain related info.No pain related info.
              • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
              Sleep
              PhenerganZofranScopolamineCompro
              • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
              • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
              No sleep related info.No sleep related info.
              • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
              • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
              Upsides and benefits
              PhenerganZofranScopolamineCompro
              • Available in generic.
              • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
              • Available in generic.
              • Available in forms that you don't have to swallow (like a tablet or film that dissolves in your mouth) if you're having trouble keeping anything down.
              • Starts working fast (in 30 minutes.
              • Even though there's no generic version available, it's inexpensive.
              • Placed on the skin so it can be used if you can't keep anything in your stomach.
              • Can be used for long-term control of nausea and vomiting since it's only placed on every 3 days.
              • Available in generic, so it's cheap.
              • Can be taken by mouth, as a shot, or rectally.
              • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
              Downsides and risks
              PhenerganZofranScopolamineCompro
              • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
              • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
              • Can make your skin more sensitive to the sun.
              • Can cause headaches.
              • Can interact with antidepressants.
              • Can only be used to prevent nausea and vomiting, not to treat if it's already happening.
              • Can only be used to prevent nausea and vomiting, not to treat it if it's already happening.
              • Takes about 4 hours for it to start working.
              • You have to avoid alcohol while on the medication.
              • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
              • Can't be used by people over 65 because they can be more affected by the side effects.
              • It can make you more likely to get heatstroke.
              Tips from our pharmacists for people taking the medication
              PhenerganZofranScopolamineCompro
              • Promethazine comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
              • Don't give to kids 2 and under.
              • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
              • Don't drink alcohol to avoid intense side effects.
              • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
              • Avoid using if you experience seizures (epilepsy).
              • Don't use if you're 65 or older because you're at higher risk for serious side effects.
              • If you're using the disintegrating tablet, make sure your hands are dry first, peel off the foil and remove the tablet. Place the tablet on the tongue to let it dissolve naturally, then swallow. Don't drink water or anything else.
              • Can cause headache, fatigue or constipation.
              • If you're taking the oral film, don't chew or swallow it. Let it dissolve naturally on the tongue.
              • It takes 30 minutes for Zofran to start working.
              • Wash your hands after you place the patch.
              • Don't touch or rub your eyes after putting on the patch before washing your hands.
              • Can cause blurry vision and sleepiness.
              • Take the patch off if you have to do an MRI.
              • Don't drink alcohol if you have to use the patch.
              • Place it on a few hours before if you know you'll be in a place where you might get motion sickness.
              • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
              • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
              • Don't drink alcohol to avoid intense side effects.
              • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
              • Avoid using if you experience seizures (epilepsy).
              • Don't use if you're 65 or older because you're at higher risk for serious side effects.
              Learn more
              More about PhenerganSide effectsReviews & ratingsAlternativesFDA package insert
              Have you used Phenergan (Promethazine)?
              Worth itNot sureNot worth it
              More about ZofranSide effectsReviews & ratingsFDA package insert
              Have you used Zofran (Ondansetron)?
              Worth itNot sureNot worth it
              More about ScopolamineSide effectsReviews & ratingsFDA package insert
              Have you used Transderm-Scop (Scopolamine)?
              Worth itNot sureNot worth it
              More about ComproSide effectsReviews & ratingsFDA package insert
              Have you used Compro (Prochlorperazine)?
              Worth itNot sureNot worth it