Prescription or OTCLower-cost generic availableClass: Respiratory

Sudafed Pe 


Prescription or OTCLower-cost generic availableClass: Respiratory
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Clears your sinuses.

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Our bottom line

Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.

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Best available price for 1 (2ml of 2.5%) eye dropper of phenylephrine


  • Works to clear nasal congestion and helps you breathe better.
  • Helpful in relieving congestion-related headaches.
  • Has fewer side effects than other decongestants like pseudoephedrine.
  • It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
  • Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
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  • Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
  • You shouldn't use it if you have high blood pressure.
  • Can make your heart race or make you feel anxious and restless.
  • Shouldn't use it before you want to sleep.
  • Not as effective after using it for 4 days in a row.
How it works

Sudafed Pe (Phenylephrine) is a decongestant. It narrows blood vessels and reduces swelling in your nasal passages to make breathing easier.

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Side effect rates for Sudafed Pe (phenylephrine)

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These are side effects of Sudafed Pe (phenylephrine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Sudafed Pe (phenylephrine)

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    • Higher risk if:
    • History of high blood pressure
    • Taking MAO inhibitors

    People taking Sudafed Pe (Phenylephrine) and MAO inhibitors together, or up to 14 days apart from each other, can experience very high blood pressure that can cause headaches and strokes. MAOI drugs are used to treat Parkinson's disease, depression, and other emotional conditions. Talk to your doctor or pharmacist if you're taking MAO inhibitors and still want to use a cough medicine.

Common concerns from people taking Sudafed Pe (phenylephrine)

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