Clears your sinuses.
Our pharmacists’ bottom line
Sudafed Pe (Phenylephrine) is a good medication for relieving stuffy nose. It doesn't work as well as pseudoephedrine (Sudafed), but it has fewer side effects.
- Works to clear nasal congestion and helps you breathe better.
- Helpful in relieving congestion-related headaches.
- Has fewer side effects than other decongestants like pseudoephedrine.
- It doesn't raise your blood pressure and heart rate as much, or cause as much trouble falling asleep.
- Doesn't give you rebound congestion (worse symptoms when you stop taking it) like nasal spray decongestants do.
- Phenylephrine doesn't last as long as other decongestants like pseudoephedrine (Sudafed).
- You shouldn't use it if you have high blood pressure.
- Can make your heart race or make you feel anxious and restless.
- Shouldn't use it before you want to sleep.
- Not as effective after using it for 4 days in a row.
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Side effects for Sudafed Pe (Phenylephrine)
What to expect when you start Sudafed Pe (Phenylephrine)Skip what to expect section. Skip to Risks & Warnings section.
- Starts working in 30 minutes.
- Phenylephrine can make you restless, so don't take it too close to bedtime.
- It's in other cold and flu combination medicines. Read labels closely so you don't accidentally double up and take too much of it in a day.
- Follow age-specific dosing instructions on how much to take.
- Let your doctor know if your symptoms don't improve in a few days.
Risks and Warnings for Sudafed Pe (Phenylephrine)Skip Risks and Warnings section. Skip to Tips section.
- Higher risk if:
- › History of high blood pressure
- › Taking MAO inhibitors
People taking Sudafed Pe (Phenylephrine) and MAO inhibitors together, or up to 14 days apart from each other, can experience very high blood pressure that can cause headaches and strokes. MAOI drugs are used to treat Parkinson's disease, depression, and other emotional conditions. Talk to your doctor or pharmacist if you're taking MAO inhibitors and still want to use a cough medicine.
Tips from pharmacists and people taking Sudafed Pe (Phenylephrine)Final section. Do you want to return to drug navigation?
- Upsides and downsides from our pharmacists
- › Shouldn't use it before you want to sleep.