Prescription onlyLower-cost generic availableClass: Autoimmune



Prescription onlyLower-cost generic availableClass: Autoimmune
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Improves inflammatory conditions like rheumatoid arthritis.

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Our bottom line

Plaquenil (Hydroxychloroquine) is a great medication for rheumatoid arthritis and comes with less side effects than other DMARDs.

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Prices and coupons for 60 (200mg) tablets of hydroxychloroquine


  • Plaquenil (Hydroxychloroquine) has been shown to improve physical function in up to 80% of patients.
  • Plaquenil (Hydroxychloroquine) and similar DMARD medications help minimize joint damage, decrease symptoms and lessen future complications.
  • Plaquenil (Hydroxychloroquine) is an excellent choice for people who have difficulty tolerating newer biologic medications.
  • A generic form of Plaquenil (Hydroxychloroquine) is available.


  • You will likely have to take additional medications like Methotrexate to keep your RA in control.
  • In some people, small particles develop in the eyes, so you’ll have to get your eyes checked once per year.
  • It can take up to 6 months before the full benefits of Plaquenil (Hydroxychloroquine) are felt.
  • Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil (Hydroxychloroquine).
How it works

Plaquenil (Hydroxychloroquine) is called a DMARD, a disease-modifying antirheumatic drug. It prevents your body from activating cells that cause inflammation.

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Side effect rates for Plaquenil (hydroxychloroquine)

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These are side effects of Plaquenil (hydroxychloroquine) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Plaquenil (hydroxychloroquine)

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  • Doctors should be completely familiar with the medication label before prescribing Plaquenil (Hydroxychloroquine).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Plaquenil (hydroxychloroquine)

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  • Certain medications can interact with Plaquenil (Hydroxychloroquine), so to be safe, tell your doctor about other medications and supplements you may be taking.
  • Stay away from alcohol while taking Plaquenil (Hydroxychloroquine).
  • Take Plaquenil with food Before starting medication see an optometrist for baseline assessment of your eyes.
  • Eat with food to help prevent stomach upset
  • This medicine has worked well for me however, I do have some side effects that are not as bad as the pain. Tinitis and headaches