Prescription onlyLower-cost generic available



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Improves inflammatory conditions like rheumatoid arthritis.

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Prescription onlyLower-cost generic available

Our bottom line

Plaquenil (Hydroxychloroquine) is a great medication for rheumatoid arthritis and comes with less side effects than other DMARDs.


  • Plaquenil (Hydroxychloroquine) has been shown to improve physical function in up to 80% of patients.
  • Plaquenil (Hydroxychloroquine) and similar DMARD medications help minimize joint damage, decrease symptoms and lessen future complications.
  • Plaquenil (Hydroxychloroquine) is an excellent choice for people who have difficulty tolerating newer biologic medications.
  • A generic form of Plaquenil (Hydroxychloroquine) is available.


  • You will likely have to take additional medications like Methotrexate to keep your RA in control.
  • In some people, small particles develop in the eyes, so you’ll have to get your eyes checked once per year.
  • It can take up to 6 months before the full benefits of Plaquenil (Hydroxychloroquine) are felt.
  • Many people have nausea, stomach cramps, and diarrhea when they first start taking Plaquenil (Hydroxychloroquine).

Save on your next Plaquenil (Hydroxychloroquine) prescription

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What to expect when you take Plaquenil (Hydroxychloroquine)

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Tips from our pharmacists
  • Don’t give up on Plaquenil (Hydroxychloroquine), it can take 2-4 months to take effect.
  • Take Plaquenil (Hydroxychloroquine) with milk to help decrease nausea.
  • If you have difficulty swallowing Plaquenil (Hydroxychloroquine), you can crush it, and mix it in jam or jelly.
  • While taking Plaquenil (Hydroxychloroquine) it is important to wear sunglasses in bright light to protect your eyes from damage. When you can’t avoid sunlight, be sure to use sunscreen, put on a long-sleeved shirt, pants, and a hat.
  • Stay away from alcohol while taking Plaquenil (Hydroxychloroquine).
  • Certain medications can interact with Plaquenil (Hydroxychloroquine), so to be safe, tell your doctor about other medications and supplements you may be taking.
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Side effects for Plaquenil (Hydroxychloroquine)

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These are side effects of Plaquenil (Hydroxychloroquine) reported to the FDA by people taking it, and by doctors and pharmacists.

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Risks and Warnings for Plaquenil (Hydroxychloroquine)

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  • Doctors should be completely familiar with the medication label before prescribing Plaquenil (Hydroxychloroquine).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Plaquenil (Hydroxychloroquine)

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The FDA category for this medication is N. It is advised that you: Unknown
  • Tips from our pharmacists
  • Stay away from alcohol while taking Plaquenil (Hydroxychloroquine).
  • Take after food. Get regular eye tests.Has stabilized my lupus and antibody levels have gone down.
  • Take Plaquenil with food Before starting medication see an optometrist for baseline assessment of your eyes.