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Prevents blood clots.

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Prescription onlyLower-cost generic available

Our bottom line

Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.


  • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
  • Studies have shown clopidogrel lowers your risk of death or further heart complications.
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  • Raises your risk of bleeding and bruising.
  • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
  • Doesn't work well for people with certain genetic variations.

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What to expect when you take Plavix (Clopidogrel) for Anticoagulant

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Tips from our pharmacists
  • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
  • Can raise your risk of bleeding or bruising.
  • Take it exactly as instructed.
  • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
  • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
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Side effects for Plavix (Clopidogrel)

From clinical trials of Plavix / Blood thinning to prevent heart attack (With aspirin vs. Placebo + aspirin)  ( 12562)

  • Minor bleedingMinor bleeding5% for Clopidogrel vs.2% for placebo
  • Major bleedingMajor bleeding4% for Clopidogrel vs.3% for placebo
  • Any noncerebral bleedingAny noncerebral bleeding4% for Clopidogrel vs.3% for placebo
  • Life-threatening bleedingLife-threatening bleeding2% for Clopidogrel vs.2% for placebo
  • Bleeding requiring transfusion (≥ 4 units)Bleeding requiring transfusion (≥ 4 units)1% for Clopidogrel vs.1% for placebo
  • Requiring 2-3 units of bloodRequiring 2-3 units of blood1% for Clopidogrel vs.0% for placebo

Manufacturers don’t say how common these side effects are

  • Other major bleeding

Risks and Warnings for Plavix (Clopidogrel)

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    • Higher risk if:
    • Genetic variation (CYP2C19 poor metabolizer)
    • Drug-interactions

    Plavix (Clopidogrel) may not work well for some people. Certain medicines that reduce stomach acid can also prevent Plavix (Clopidogrel) from working. Your doctor may order a genetic test to make sure Plavix (Clopidogrel) is right for you. Do not start anything new without first talking to your doctor.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Plavix (Clopidogrel)

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The FDA category for this medication is B. It is advised that you: Probably safe