Prescription onlyLower-cost generic availableClass: Cardiovascular

Plavix Alternatives

(clopidogrel)

Prescription onlyLower-cost generic availableClass: Cardiovascular
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Compare Plavix (clopidogrel) to alternatives

These medications are comparable to Plavix (clopidogrel) or used for similar purposes.

Plavix
(clopidogrel)

Coumadin
(warfarin)

aspirin

Effient
(prasugrel)

Lovenox
(enoxaparin)

heparin

Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.Prevents blood clots. Coumadin (warfarin) is a cheap and effective medicine that prevents new blood clots. It requires regular blood tests and you'll need to eat, exercise, and take your medicines consistently.Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.Coming soon.Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.Prevents blood clots. Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5Plavix
Reviews for Plavix
59%
of people (All ages) say Plavix is worth it
49%
say it works well
16%
say it's a big hassle
343 reviews
Have you used Plavix (clopidogrel)?
Worth itNot sureNot worth it
Reviews for Coumadin
61%
-2% worse vs. Plavix
54%
-5% worse vs. Plavix
21%
+5% better vs. Plavix
513 reviews
Have you used Coumadin (warfarin)?
Worth itNot sureNot worth it
Reviews for Aspirin
76%
-17% worse vs. Plavix
41%
+8% better vs. Plavix
6%
-10% worse vs. Plavix
533 reviews
Have you used Aspirin?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Effient (prasugrel)?
Worth itNot sureNot worth it
Reviews for Lovenox
63%
-4% worse vs. Plavix
63%
-14% worse vs. Plavix
16%
Same vs. Plavix
Have you used Lovenox (enoxaparin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Heparin?
Worth itNot sureNot worth it
Side effects
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »

We haven’t found good data for Effient side effects.

FDA side effect reports for Effient »
  • Injection site hematoma 7%
  • Excessive bleeding 7%
  • Major hemorrhage 4%
  • Nausea 1%
  • Confusion 1%
  • Fever 2%
More Lovenox side effects »

We haven’t found good data for Heparin side effects.

FDA side effect reports for Heparin »
How it works
PlavixCoumadinAspirinEffientLovenoxHeparin
Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.Coumadin (warfarin) prevents blood clots from forming. It doesn't break up clots that already exist. It can only stop new ones from forming or old ones from getting bigger.Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.Coming soon.Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.Heparin is an anticoagulant that binds with proteins and platelets to stop blood clots from being made and traveling to the brain, heart, and lungs.
Type of medication
PlavixCoumadinAspirinEffientLovenoxHeparin
Prescription onlyPrescription onlyOver-the-counterPrescription onlyPrescription only
Available as
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Pill
  • Pill
  • Pill
  • Pill
  • Injection
  • Injection
Used for
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Heart Attack Or Pre Heart Attack Percutaneous Coronary Intervention Thrombosis Prophylaxis
Risk factors for serious side effects
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
Detailed Plavix (clopidogrel) risks & warnings »
  • Coumadin (warfarin) dose too high
  • Age greater than 65 year
  • History of stomach bleeding
  • High blood pressure
  • Kidney or liver problems
Detailed Coumadin (warfarin) risks & warnings »
  • Children 18 years or younger
  • Children recovering from viral infections
  • History of stomach bleeding or ulcers
  • Age 60 years or older
  • Taking Aspirin, NSAIDs, or blood thinners
Detailed Aspirin risks & warnings »
    Coming soon.
    • Spinal puncture (spinal tap)
    • Getting anesthesia in the spine (epidural anesthesia)
    • Taking NSAIDs or other blood thinning medicines
    • History of bleeding problems
    • Severe high blood pressure
    Detailed Lovenox (enoxaparin) risks & warnings »
    • History of bleeding problems
    • Severe high blood pressure
    • Older age
    • Heparin-induced thrombocytopenia
    Detailed Heparin risks & warnings »
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Interactions
    PlavixCoumadinAspirinEffientLovenoxHeparin
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Coumadin (warfarin) interacts with many drugs and supplements. This can increase your risk of bleeding or of developing a new blood clot. If you start a new medication or change your diet, let your doctor know so they can change your dose if necessary.
    • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
    No interactions related info.No interactions related info.No interactions related info.No interactions related info.
    Food
    PlavixCoumadinAspirinEffientLovenoxHeparin
    No food related info.No food related info.
    • Take with food to lower the chance of an upset stomach.
    No food related info.
    • Available in generic so it can be cheaper than other "blood thinners".
    No food related info.
    Pain
    PlavixCoumadinAspirinEffientLovenoxHeparin
    No pain related info.No pain related info.
    • Used in higher doses to relieve pain, swelling, and fever.
    No pain related info.No pain related info.No pain related info.
    Upsides and benefits
    PlavixCoumadinAspirinEffientLovenoxHeparin
    • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
    • Studies have shown clopidogrel lowers your risk of death or further heart complications.
    • Coumadin (warfarin) is available as a generic, so it should be less expensive than the brand version.
    • In case you start bleeding too much while using Coumadin (warfarin), your doctor can give you another drug that reverses Coumadin (warfarin)'s effects.
    • Coumadin (warfarin) comes in numerous strengths.
    • Coumadin (warfarin) has been around for a long time and is one of the most commonly used 'blood thinner' medicines.
    • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
    • Used in higher doses to relieve pain, swelling, and fever.
    • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
    Coming soon
    • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
    • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
    • Available in generic so it can be cheaper than other "blood thinners".
    • Good option if you're pregnant or have cancer.
    • Safe to use in pregnancy and if you're breast feeding.
    • There are other medications that can help stop unexpected bleeding while taking Heparin.
    • Available as a generic medication.
    • Usually used in the hospital, but can be given at home too.
    Downsides and risks
    PlavixCoumadinAspirinEffientLovenoxHeparin
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Doesn't work well for people with certain genetic variations.
    • Raises your risk of bleeding and bruising.
    • Requires regular blood work, such as an INR, to make sure Coumadin (warfarin) is working correctly.
    • Your daily dose of Coumadin (warfarin) can change if you change your diet, exercise patterns, or use of alcohol.
    • A lot of other drugs and supplements interact with Coumadin (warfarin), so you'll need to check with your doctor or pharmacist before starting any new medicines.
    • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
    • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
    • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
    • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
    Coming soon
    • It is only available as an injection, so it's not great if you're afraid of needles.
    • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
    • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
    • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
    • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
    Tips from our pharmacists for people taking the medication
    PlavixCoumadinAspirinEffientLovenoxHeparin
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Can raise your risk of bleeding or bruising.
    • Take it exactly as instructed.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
    • Prevents clots from forming or getting bigger. It doesn't break up clots that already exist.
    • Take Coumadin (warfarin) exactly as your doctor tells you.
    • Once you're taking Coumadin (warfarin), it'll take longer for your body to heal if you get cut or bruised. Call your doctor if you notice any unusual bleeding or bruising.
    • Carry a list of your medications with you or wear a medical bracelet that says you're on Coumadin (warfarin) in case you have a medical emergency.
    • Your doctor will check your blood regularly for the first few months that you're taking Coumadin (warfarin).
    • To get the best results, don't fall behind on taking your other medicines and eat the same amount of vegetables each day.
    • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
    • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
    • Take with food to lower the chance of an upset stomach.
    • Don't use for kids younger than 18 years old.
    • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
    Coming soon
    • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
    • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
    • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
    • Can cause swelling in your legs, diarrhea, and nausea.
    • Make sure to change where you inject Heparin every time.
    • Don't take aspirin or other anti-inflammatory medications without talking to your doctor first.
    • You will have to do regular blood draws or labs to make sure that Heparin is working for you.
    Learn more
    More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Plavix (clopidogrel)?
    Worth itNot sureNot worth it
    More about CoumadinSide effectsReviews & ratingsFDA package insert
    Have you used Coumadin (warfarin)?
    Worth itNot sureNot worth it
    More about AspirinSide effectsReviews & ratingsFDA package insert
    Have you used Aspirin?
    Worth itNot sureNot worth it
    More about EffientSide effectsFDA package insert
    Have you used Effient (prasugrel)?
    Worth itNot sureNot worth it
    More about LovenoxSide effectsReviews & ratingsFDA package insert
    Have you used Lovenox (enoxaparin)?
    Worth itNot sureNot worth it
    More about HeparinSide effectsReviews & ratingsFDA package insert
    Have you used Heparin?
    Worth itNot sureNot worth it