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Compare Plavix (Clopidogrel) to alternatives

These medications are comparable to Plavix (Clopidogrel) or used for similar purposes.

Plavix
(Clopidogrel)

Coumadin
(Warfarin)

Aspirin

Effient
(Prasugrel)

Lovenox
(Enoxaparin)

Heparin

Prevents blood clots. Plavix (Clopidogrel) works well to prevent blood clots and heart complications, but watch out for drug interactions.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.Relieves pain, fever, and inflammation. Protects your heart and thins blood. A low dose of Aspirin (81mg) every day can protect your heart, but it's not the best medicine to take for pain, swelling, or fever.Coming soon.Prevents blood clots. Lovenox (Enoxaparin) is a good anticoagulant that reduces the risk of death or bleeding, and blood clots are less likely to happen. However, it is only available as an injection which isn't great if you're afraid of needles.Prevents blood clots. Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.002949852507375Plavix
Reviews for Plavix (Clopidogrel)
59%
of people say Plavix (Clopidogrel) is worth it
49%
say it works well
16%
say it's a big hassle
Reviews for Coumadin (Warfarin)
61%
+2% vs. Plavix (Clopidogrel)
54%
+5% vs. Plavix (Clopidogrel)
21%
5% vs. Plavix (Clopidogrel)
Reviews for Aspirin
76%
+17% vs. Plavix (Clopidogrel)
41%
8% vs. Plavix (Clopidogrel)
6%
+10% vs. Plavix (Clopidogrel)

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Side effects
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Minor bleeding 3%
  • Major bleeding 1%
  • Any noncerebral bleeding 1%
More Plavix side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »

We haven’t found good data for Aspirin side effects.

FDA side effect reports for Aspirin »

We haven’t found good data for Effient side effects.

FDA side effect reports for Effient »
  • Injection site hematoma 7%
  • Fever 2%
  • Confusion 1%
  • Nausea 1%
More Lovenox side effects »

We haven’t found good data for Heparin side effects.

FDA side effect reports for Heparin »
How it works
PlavixCoumadinAspirinEffientLovenoxHeparin
Plavix (Clopidogrel) is an antiplatelet blood thinner. It prevents blood platelets from working, which makes it harder for your body to form blood clots.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.Aspirin is a salicylate and non-steroidal anti-inflammatory drug (NSAID). It blocks the inflammation process in your body, which relieves swelling and pain. It also prevents blood platelets from forming clots, which thins your blood.Coming soon.Lovenox (Enoxaparin) is an anticoagulant that prevents certain blood-clotting proteins from working. By stopping blood clots from forming, there's a lower chance of having a stroke or blood clots travel to your lungs.Heparin is an anticoagulant that binds with proteins and platelets to stop blood clots from being made and traveling to the brain, heart, and lungs.
Type of medication
PlavixCoumadinAspirinEffientLovenoxHeparin
Anticoagulant
Anti-platelet
Prescription only
Anticoagulant
Vitamin K antagonist
Prescription only
Pain reliever
Salicylate
Anticoagulant
Anti-platelet
Over-the-counter
Coming soon.
Anticoagulant
Heparin
Prescription only
Anticoagulant
Heparin
Prescription only
Available as
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Pill
  • Pill
  • Pill
  • Pill
  • Injection
  • Injection
Used for (click to learn more)
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Heart attack or pre-heart attack - Percutaneous coronary intervention - Thrombosis; Prophylaxis
Risk factors for serious side effects
PlavixCoumadinAspirinEffientLovenoxHeparin
  • Genetic variation (CYP2C19 poor metabolizer)
  • Drug-interactions
  • Age greater than 65
  • History of gastrointestinal bleeding
  • High blood pressure
  • Liver problems
  • Drug interactions
  • Certain genetic disposition
    Detailed Plavix (Clopidogrel) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    PlavixCoumadinAspirinEffientLovenoxHeparin
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    NFDA pregnancy category (Unknown)

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    BFDA pregnancy category (Probably safe)

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Eat foods containing consistent amounts of Vitamin K.
    • Take with food to lower the chance of an upset stomach.
    No specific food-related info.No specific food-related info.No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
    No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    PlavixCoumadinAspirinEffientLovenoxHeparin
    • Thins your blood to protect your heart after a heart attack or after a procedure on your heart.
    • Studies have shown clopidogrel lowers your risk of death or further heart complications.
    • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
    • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
    • Has an antidote, Vitamin K, in case of a major accidental bleeding.
    • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
    • It's dirt cheap.
    • When taking low doses (81 mg) every day, Aspirin provides protection for your heart and prevents heart attacks and stroke.
    • Used in higher doses to relieve pain, swelling, and fever.
    • Available over-the-counter in drugstores by itself and in combination with other cold and flu medications.
    Coming soon.
    • In a study that compared Lovenox (Enoxaparin) to other medications used to stop blood clots, there was a lower risk of clots coming back, with similar rates of major bleeding and mortality.
    • You don't need to go in for lab tests to check whether it's working, unlike other medications like warfarin that require regular blood draws.
    • Available in generic so it can be cheaper than other "blood thinners".
    • Good option if you're pregnant or have cancer.
    • Safe to use in pregnancy and if you're breast feeding.
    • There are other medications that can help stop unexpected bleeding while taking Heparin.
    • Available as a generic medication.
    • Usually used in the hospital, but can be given at home too.
    Downsides and risks
    PlavixCoumadinAspirinEffientLovenoxHeparin
    • Doesn't work well for people with certain genetic variations.
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    • Raises your risk of bleeding and bruising.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Not a preferred medication for treating pain, swelling, or fever due to its high risk of bleeding.
    • NSAIDs (like ibuprofen and naproxen) and acetaminophen (Tylenol) are better for treating pain and fever thank Aspirin.
    • Aspirin raises your risk of bleeding, especially when used with other blood thinner medications like warfarin (Coumadin).
    • Studies show that using higher doses of Aspirin (162 mg or more) every day raises your risk of stomach bleeding and doesn't provide any additional heart protection.
    Coming soon.
    • It is only available as an injection, so it's not great if you're afraid of needles.
    • While surprise bleeding episodes can be treated while taking Lovenox (Enoxaparin), they won't completely work.
    • It doesn't work as well as other medications for "thinning the blood" if you are overweight, underweight, or if you have kidney disease.
    • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
    • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
    Tips from our pharmacists for people taking the medication
    PlavixCoumadinAspirinEffientLovenoxHeparin
    • Let your doctor know about any fever, weakness, or unusual bleeding or bruising.
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Can raise your risk of bleeding or bruising.
    • Take it exactly as instructed.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • The amount you need depends on your diet, other medical problems, and genes.
    • Requires regular blood tests to get your dose right.
    • Eat foods containing consistent amounts of Vitamin K.
    • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
    • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • Take it exactly as instructed.
    • Can raise your risk of bleeding or bruising.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Using low doses (81mg) of Aspirin every day can lower your risk of heart attack and stroke, but it isn't good for everyone. Only take Aspirin daily if your doctor recommends it.
    • Higher Aspirin doses can be used to treat occasional pain, swelling, and fever. Using ibuprofen or acetaminophen (Tylenol) instead can lower your risk of serious bleeding.
    • Take with food to lower the chance of an upset stomach.
    • Don't use for kids younger than 18 years old.
    • Stop taking this right away and tell your doctor if you have ringing in your ears, unusual bleeding, or nausea or vomiting that doesn't go away.
    Coming soon.
    • Rotate the spot where you inject Lovenox (Enoxaparin) every day.
    • While on this, it can take longer to stop bleeding and you are more likely to bruise or bleed more easily.
    • Avoid taking certain anti-inflammatory drugs (like NSAIDs) because they can make you more likely to bleed.
    • Can cause swelling in your legs, diarrhea, and nausea.
    • Make sure to change where you inject Heparin every time.
    • Don't take aspirin or other anti-inflammatory medications without talking to your doctor first.
    • You will have to do regular blood draws or labs to make sure that Heparin is working for you.
    Learn more
    More about PlavixSide effectsReviews & ratingsAlternativesFDA package insert
    More about CoumadinSide effectsReviews & ratingsFDA package insert
    More about AspirinSide effectsReviews & ratingsFDA package insert
    More about EffientSide effectsFDA package insert
    More about LovenoxSide effectsReviews & ratingsFDA package insert
    More about HeparinSide effectsReviews & ratingsFDA package insert