Prescription onlyNo lower cost generic available

Pradaxa Alternatives

(Dabigatran)

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Compare Pradaxa (Dabigatran) to alternatives

These medications are comparable to Pradaxa (Dabigatran) or used for similar purposes.

Pradaxa
(Dabigatran)

Aggrenox
(Aspirin / Dipyridamole)

Coumadin
(Warfarin)

Xarelto
(Rivaroxaban)

Heparin

Prevents blood clots. Pradaxa (Dabigatran) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Prevents blood clots that can cause a stroke. Aggrenox (Aspirin / Dipyridamole) prevents blood clots and stroke, but cheaper options are available that work just as well.Prevents blood clots. Coumadin (Warfarin) is an old, cheap, and effective medicine to prevent blood clots, but it requires some monitoring, dose adjustments, and even lifestyle changes.Prevents blood clots. Xarelto (Rivaroxaban) is a good medication for preventing blood clots. It doesn't require regular blood tests or changing doses often. It can be expensive and there's no way to reverse the medication's effects.Prevents blood clots. Heparin is a good anticoagulant that prevents blood clots. However, you'll need to get frequent blood tests to make sure it's working well.
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Reviews & ratings
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Reviews for Coumadin (Warfarin)
61%
+11% vs. Pradaxa (Dabigatran)
54%
+4% vs. Pradaxa (Dabigatran)
21%
21% vs. Pradaxa (Dabigatran)

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Side effects
PradaxaAggrenoxCoumadinXareltoHeparin

The Pradaxa FDA package insert doesn’t have numbers about how common side effects are.

More about Pradaxa side effects »
  • Headache 10%
  • Abdominal pain 6%
  • Nausea 6%
  • Diarrhea 3%
  • Indigestion 3%
  • Hemorrhage nos 2%
  • Back pain 1%
  • Dizziness 1%
  • Black "tarry" stools 1%
  • Feeling unwell 1%
More Aggrenox side effects »

The Coumadin FDA package insert doesn’t have numbers about how common side effects are.

More about Coumadin side effects »
  • Back pain 3%
More Xarelto side effects »

We haven’t found good data for Heparin side effects.

FDA side effect reports for Heparin »
How it works
PradaxaAggrenoxCoumadinXareltoHeparin
Pradaxa (Dabigatran) is an anticoagulant that stops the formation of blood clots.Aggrenox (Aspirin / Dipyridamole) is an antiplatelet blood thinner. It is a combination medication with two ingredients, aspirin and dipyridamole. Both make it harder for your body to form blood clots.Coumadin (Warfarin) is an anticoagulant blood thinner. It lowers chemicals called clotting factors so that it's harder for your body to form blood clots.Xarelto (Rivaroxaban) is an anticoagulant that stops the formation of blood clots.Heparin is an anticoagulant that binds with proteins and platelets to stop blood clots from being made and traveling to the brain, heart, and lungs.
Type of medication
PradaxaAggrenoxCoumadinXareltoHeparin
Anticoagulant
Thrombin inhibitor
Prescription only
Anticoagulant
Anti-platelet
Prescription only
Anticoagulant
Vitamin K antagonist
Prescription only
Anticoagulant
Factor Xa inhibitor
Prescription only
Anticoagulant
Heparin
Prescription only
Available as
PradaxaAggrenoxCoumadinXareltoHeparin
  • Pill
  • Pill
  • Pill
  • Pill
  • Injection
Used for (click to learn more)
PradaxaAggrenoxCoumadinXareltoHeparin
Risk factors for serious side effects
PradaxaAggrenoxCoumadinXareltoHeparin
  • Stopping Pradaxa (Dabigatran) too soon
  • Spinal tap
  • Anesthesia along the spine (epidural anesthesia)
  • Taking NSAIDs, aspirin, or other blood-thinning medicines
  • Drug interactions
  • Taking with NSAIDs, aspirin, or other blood-thinning medicines
    • Artificial heart valve
    Detailed Pradaxa (Dabigatran) risks & warnings »
    Coming soon.Coming soon.Coming soon.Coming soon.
    Pregnancy category
    PradaxaAggrenoxCoumadinXareltoHeparin
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    DFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    XFDA pregnancy category (Unsafe)

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    CFDA pregnancy category (Weigh risks vs. benefits)

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    See the FDA package insert
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    No specific food-related info.
    • Do not crush or chew capsules. Can take with or without food.
    • Eat foods containing consistent amounts of Vitamin K.
    • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
    • Take Xarelto (Rivaroxaban) with food and a full glass of water.
    No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
    Sleep
    No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
    Weight
    No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    PradaxaAggrenoxCoumadinXareltoHeparin
    • Clinical studies have shown that the risk of stroke and blood clots is lower than with warfarin, another popular "blood thinner" (anticoagulant).
    • Doesn't require regular blood tests or frequent dose changes.
    • In studies comparing Pradaxa (Dabigatran) to other "blood thinners", it worked just as well in preventing strokes and was better in lowering the risk of bleeding.
    • This helps to prevent strokes for people who had a stroke or TIA (transient ischemic attack) before.
    • In clinical studies, Aggrenox (Aspirin / Dipyridamole) lowered the chance of another stroke for a person with a previous stroke or mini-stroke (TIA) by 36%.
    • Works better than either aspirin or dipyridamole alone to prevent strokes.
    • Works as well as Plavix (clopidogrel), another antiplatelet medication, to prevent stroke.
    • Oral blood-thinning medicine that prevents blood clots from forming or getting bigger.
    • Prevents complications of blood clots that can cause extreme discomfort or death. Examples include stroke (blood clots in the brain), pulmonary embolism (blood clots in the lungs causing trouble breathing), or deep vein thrombosis (blood clots in the legs causing pain and blood vessel damage).
    • Has an antidote, Vitamin K, in case of a major accidental bleeding.
    • Coumadin (Warfarin) has been around for a long time, so we know a lot about how well it works and what the risks are.
    • It's dirt cheap.
    • Studies have shown that Xarelto (Rivaroxaban) works just as well as other blood thinners (anticoagulants) in preventing strokes and reducing bleeding.
    • Xarelto (Rivaroxaban) doesn't require regular blood testing or frequent dose adjustments.
    • Xarelto (Rivaroxaban) doesn't have as many food interactions as compared to other anticoagulants like warfarin (Coumadin).
    • Safe to use in pregnancy and if you're breast feeding.
    • There are other medications that can help stop unexpected bleeding while taking Heparin.
    • Available as a generic medication.
    • Usually used in the hospital, but can be given at home too.
    Downsides and risks
    PradaxaAggrenoxCoumadinXareltoHeparin
    • Not available as generic.
    • There are no antidotes to stop bleeding caused by taking too much Pradaxa (Dabigatran).
    • Can't take during pregnancy.
    • Raises your risk for bleeding and bruising.
    • Has to be taken twice a day unlike Plavix that only has to be taken once daily.
    • Can be more expensive than other alternatives that are available as a generic.
    • Can't be used by people with an aspirin allergy, or a history of stomach ulcers.
    • Raises your risk of bleeding and bruising.
    • Requires routine blood testing (called an INR) to see how well the medicine is working for you and to make the dose just right for you.
    • Many lifestyle factors can affect how well warfarin works, such as diet, alcohol, and activity level, so it's important that you try to stay consistent with your behaviors.
    • Lots of interactions with other drugs or supplements. Always check with your doctor or pharmacist before starting any new meds.
    • Xarelto (Rivaroxaban) can increase your risk of bleeding. Call your doctor right away if there is blood in your phlegm, urine, or stool (look for black, tarry stools).
    • Xarelto (Rivaroxaban) isn't available as a generic medication.
    • There are no antidotes to stop bleeding caused by taking too much Xarelto (Rivaroxaban).
    • Can't take during pregnancy.
    • You'll need to get labs/blood draws done on a regular basis to make sure the drug is working and to make sure you don't get unexpected side effects.
    • You can be at higher risk for bleeding or clotting while taking Heparin compared to other anticoagulants.
    Tips from our pharmacists for people taking the medication
    PradaxaAggrenoxCoumadinXareltoHeparin
    • Pradaxa (Dabigatran) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
    • When taking Pradaxa (Dabigatran), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
    • Take this exactly as your doctor or pharmacist tells you to.
    • Take with a full glass of water. Swallow the capsule whole. Don't chew, break, or open the capsule.
    • Take twice daily.
    • Do not crush or chew capsules. Can take with or without food.
    • Aggrenox (Aspirin / Dipyridamole) can cause unexpected bleeding or bruising.
    • Don't take if you're allergic to aspirin.
    • Headache is a common side effect, but it often goes away after the first week of use.
    • Thins your blood to prevent clots from forming or getting bigger. Doesn't break up existing clots.
    • The amount you need depends on your diet, other medical problems, and genes.
    • Take it exactly as instructed.
    • Can raise your risk of bleeding or bruising.
    • Requires regular blood tests to get your dose right.
    • Interacts with a lot of medicines and supplements. Don't start any new meds without talking to your doctor.
    • Eat foods containing consistent amounts of Vitamin K.
    • Tell your doctor immediately if you fell or if you have unusual bleeding, bruising, swelling, or changes in vision and coordination.
    • Get a medical bracelet so that people know you're on a blood thinner during an emergency situation.
    • Xarelto (Rivaroxaban) is an anticoagulant, so it's important not to miss a dose. Don't stop taking this medication without talking to your doctor first.
    • When taking Xarelto (Rivaroxaban), you can bleed more easily, so use a soft toothbrush and an electric razor to avoid cutting yourself.
    • Take Xarelto (Rivaroxaban) with food and a full glass of water.
    • You can crush the tablets and mix with applesauce.
    • Make sure to change where you inject Heparin every time.
    • Don't take aspirin or other anti-inflammatory medications without talking to your doctor first.
    • You will have to do regular blood draws or labs to make sure that Heparin is working for you.
    Learn more
    More about PradaxaSide effectsReviews & ratingsAlternativesFDA package insert
    More about AggrenoxSide effectsReviews & ratingsFDA package insert
    More about CoumadinSide effectsReviews & ratingsFDA package insert
    More about XareltoSide effectsReviews & ratingsFDA package insert
    More about HeparinSide effectsReviews & ratingsFDA package insert