Prescription onlyLower-cost generic availableClass: Autoimmune

Deltasone Alternatives

(prednisone)

Prescription onlyLower-cost generic availableClass: Autoimmune
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Compare Deltasone (prednisone) to alternatives

These medications are comparable to Deltasone (prednisone) or used for similar purposes.

Deltasone
(prednisone)

Medrol
(methylprednisolone)

Decadron
(dexamethasone)

Omnipred
(prednisolone acetate)

Cortef
(hydrocortisone)

Calms down your immune system. Deltasone (prednisone) is effective for controlling allergic reactions and conditions involving the immune system. It can quickly make you feel better, but Deltasone (prednisone) can cause serious complications and side effects if taken for a long time.Calms down your immune system. Medrol (methylprednisolone) is very effective for controlling allergic reactions and many types of inflammatory conditions, but it is associated with serious and potentially life-threatening side effects if you have to take it for a long time.Calms down your immune system. Decadron (dexamethasone) is a long-acting oral corticosteroid that is very effective in treating allergic reactions and immune conditions, however, if you're taking Decadron (dexamethasone) for a long time, there can be serious side effects.Calms down redness and swelling in the eye. Omnipred (prednisolone acetate) is a steroid used in the eye that is effective for treatment and symptom relief, but with long-term use, it can have some side effects.Cortef (Hydrocortisone) lowers inflammation, suppresses the immune system, and replaces low cortisol. Cortef (Hydrocortisone) is identical to an essential hormone that humans produce and has been proven to work safely.
Reviews & ratings
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4.8prednisone
Reviews for prednisone
59%
of people (All ages) say prednisone is worth it
45%
say it works well
20%
say it's a big hassle
540 reviews
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
Reviews for Medrol
59%
Same vs. prednisone
53%
-8% worse vs. prednisone
23%
+3% better vs. prednisone
Have you used Medrol (methylprednisolone)?
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Have you used Decadron (dexamethasone)?
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Have you used Omnipred (prednisolone acetate)?
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Have you used Cortef (hydrocortisone)?
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Side effects
prednisoneMedroldexamethasoneprednisolone acetateCortef

The prednisone FDA package insert doesn’t have numbers about how common side effects are.

More about prednisone side effects »

The Medrol FDA package insert doesn’t have numbers about how common side effects are.

More about Medrol side effects »

The dexamethasone FDA package insert doesn’t have numbers about how common side effects are.

More about dexamethasone side effects »

The prednisolone acetate FDA package insert doesn’t have numbers about how common side effects are.

More about prednisolone acetate side effects »

We haven’t found good data for Cortef side effects.

FDA side effect reports for Cortef »
How it works
prednisoneMedroldexamethasoneprednisolone acetateCortef
Deltasone (prednisone) is a corticosteroid similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.Medrol (methylprednisolone) is a corticosteroid that is similar to a hormone your body naturally makes in response to stress. It helps reduce swelling and blocks the actions of your immune system that normally would cause pain, discomfort, or harm.Decadron (dexamethasone) is a corticosteroid that is similar to what your body naturally makes. It reduces swelling and other immune responses that can cause you pain, discomfort, or harm.Prednisolone acetate is a steroid that is similar to your body's natural steroids. It reduces swelling in the eye and alleviates pain, discomfort, or harm.Cortef (Hydrocortisone) is a short-acting corticosteroid. It lowers inflammation by preventing your capillaries (small blood vessels) from leaking out excess fluid and chemicals that cause swelling.
Type of medication
prednisoneMedroldexamethasoneprednisolone acetateCortef
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Pill
  • Delayed release pill
  • Liquid
  • Pill
  • Injection
  • Pill
  • Liquid
  • Liquid
  • Pill
  • Liquid
  • Suppository
Used for
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Allergies
  • Inflammation Of The Eye
Risk factors for serious side effects
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Taking high doses of Deltasone (prednisone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Deltasone (prednisone) for a long time
Detailed Deltasone (prednisone) risks & warnings »
  • Taking high doses of Medrol (methylprednisolone) for a long period of time
  • Young children
  • Stress such as trauma, injury, or infection
  • Taking other medicines that weaken the immune system
  • Taking Medrol (methylprednisolone) for a long time
Detailed Medrol (methylprednisolone) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Taking other immunosuppressants
  • Long-term treatment
  • Not vaccinated against viral diseases
Detailed Decadron (dexamethasone) risks & warnings »
  • Asthma
Detailed Omnipred (prednisolone acetate) risks & warnings »
  • Lowering dose or stopping too quickly especially after long-term treatment
  • Stress such as trauma, surgery or infection
  • Long-term treatment
  • Not vaccinated against viral diseases
  • Contact with people who have viral illness
Detailed Cortef (hydrocortisone) risks & warnings »
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Price
prednisoneMedroldexamethasoneprednisolone acetateCortef
No price related info.No price related info.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
No price related info.No price related info.
Food
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Take Decadron (dexamethasone) in the morning with food to minimize stomach upset. If taking an evening dose, take 2-3 hours before bedtime to help you sleep better at night.
No food related info.No food related info.
Kidneys and liver
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Deltasone (prednisone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
  • Medrol (methylprednisolone) can cause high blood pressure, unexplained weight gain, and other changes in the way your kidneys work. If you have a history of heart failure, high blood pressure, or kidney problems, talk to your doctor first before using this medicine.
  • Decadron (dexamethasone) can cause high blood pressure, increased salt retention and increased processing of electrolytes by your kidneys. If you have heart failure, high blood pressure, or kidney damage, talk to your doctor.
No kidneys and liver related info.
  • Adrenal suppression leading to adrenal crisis can occur if you lower your dose or stop taking Cortef (Hydrocortisone) too quickly. Symptoms include joint or muscle pain, extreme low energy and depression. Changes in your Cortef (Hydrocortisone) dose need to be done slowly over time. Talk to your doctor before you make any changes or stop the medication.
Pain
prednisoneMedroldexamethasoneprednisolone acetateCortef
No pain related info.No pain related info.
  • Taking Decadron (dexamethasone) increases the risk of injury to the lining of your stomach and intestine including irritation and tears. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor and get medical care right away if you have stomach pain or bloody/dark stools when you go to the bathroom.
  • Decadron (dexamethasone) can increase your chance of infection. Call your doctor right away if you have a fever, chills, flu-like signs, cough, pain with passing urine, or a wound that will not heal.
  • If inflammation or pain gets worse or lasts longer than 2 days while taking Omnipred (prednisolone acetate), talk to your doctor.
  • Taking Cortef (Hydrocortisone) increases the risk of injury to the lining of your stomach and intestine including irritation, tears/holes and ulcers. You should avoid alcohol/alcoholic beverages because it can worsen stomach irritation. Tell your doctor or get medical care right away if you have stomach pain, notice blood or dark colored stools when you go to the bathroom.
Weight
prednisoneMedroldexamethasoneprednisolone acetateCortef
No weight related info.No weight related info.No weight related info.No weight related info.
  • Some people gain weight while taking Cortef (Hydrocortisone). Using a weight loss program, eating smaller portions, and drinking a glass of water before meals tend to help.
Upsides and benefits
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Deltasone (prednisone) effectively treats a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Good long-term treatment option for autoimmune disorders.
  • Deltasone (prednisone) is available in a generic form.
  • Medrol (methylprednisolone) is effective for treating a variety of conditions involving the immune system.
  • Can help improve energy and stimulate your appetite.
  • Works quickly to provide relief for swelling, rash, asthma attacks, and pain.
  • Medrol (methylprednisolone) is available in a generic form.
  • Available as blister packs that organize tablets into specific days and times for easier administration.
  • Effective in treating many conditions.
  • Can improve energy and appetite.
  • Can control immune responses that are causing you discomfort and works quickly to relieve symptoms like swelling, rash, asthma attacks, and pain.
  • Has long-term benefit in calming down the immune system and keeping it from causing your body harm, such as in autoimmune conditions.
  • Available in generic form.
  • Omnipred (prednisolone acetate) works only within the eye, so it will relieve symptoms without having the side effects of oral steroids.
  • Kicks in relatively quickly to relieve symptoms.
  • Available in generic form.
  • Normal doses of hydrocortisone have been safely and successfully used for over 60 years. It's especially good for people using it as a long-term cortisol supplement.
  • Cortef (Hydrocortisone) converts into cortisol, a natural hormone, which will not interfere with other medications you may be taking.
  • Taking a dose of Cortef (Hydrocortisone) in the evening doesn't affect your ability to sleep.
  • At safe doses, Cortef (Hydrocortisone) can actually increase your body's ability to fight infection.
Downsides and risks
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Deltasone (prednisone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Deltasone (prednisone) is used for more than 2 weeks, you will need to work with a doctor to taper off the medicine by gradually decreasing the dose.
  • Deltasone (prednisone) can harm an unborn baby, so it's not a good option for pregnant women.
  • Medrol (methylprednisolone) can cause unwanted side effects such as mood changes, trouble sleeping, and increase in blood pressure as well as blood sugar at higher doses.
  • Long-term use can cause problems to your skin, bones, eyes, and place you at a higher risk for infections.
  • If Medrol (methylprednisolone) is used for more than 2 weeks, you will need to work with a doctor to get off of the medicine by gradually decreasing the dose.
  • Medrol (methylprednisolone) can cause harm to an unborn baby, so it might not be a good option for pregnant women.
  • Might cause abnormal growth and development when used in children.
  • Many side effects, particularly with long term use.
  • Side effects include mood changes, trouble sleeping and increase in blood pressure and blood sugar at higher doses.
  • Long-term use can cause problems with skin, bone, eye health and put you at a higher risk for infections.
  • If you've been using corticosteroids for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly.
  • Limited studies conducted with use of steroids during pregnancy or breastfeeding - potential harm to unborn baby.
  • Depending on the condition, you might have to use Omnipred (prednisolone acetate) up to 4 times a day, particularly in the beginning.
  • If using Omnipred (prednisolone acetate) long-term, may require some monitoring by your doctor.
  • Contains sulfite, so depending on the severity of your allergy, may not be suitable for those with allergies to sulfite.
  • Long-term use can lead to increased risk of more serious side effects.
  • In the first few weeks, your doctor might adjust the dose of Cortef (Hydrocortisone) multiple times.
  • You may be at an increased risk of infection if you take high doses of Cortef (Hydrocortisone), or if you take it in combination with other immunosuppressive medications.
  • Your body could stop making its own cortisol once it gets used to Cortef (Hydrocortisone). If so, you'll likely have to keep taking Cortef (Hydrocortisone) for a really long time.
  • Depending on why your doctor prescribed Cortef (Hydrocortisone) to you, corticosteroids can have different effects on your body.
Tips from our pharmacists for people taking the medication
prednisoneMedroldexamethasoneprednisolone acetateCortef
  • Take Deltasone (prednisone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Deltasone (prednisone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Deltasone (prednisone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Deltasone (prednisone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • Deltasone (prednisone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
  • Take Medrol (methylprednisolone) in the morning with food to lower your chances of getting stomach upset and having trouble sleeping. For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
  • Medrol (methylprednisolone) can increase your appetite, make your body retain more water, and cause changes to your mood.
  • Medrol (methylprednisolone) can increase your blood pressure and blood sugar at higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Medrol (methylprednisolone) for longer than 2 weeks, you may need to gradually stop taking this medicine. Take it exactly as your doctor told you and do not stop suddenly.
  • While you are on this medicine, don't get any live vaccines, unless approved by your doctor.
  • Medrol (methylprednisolone) can increase your chances of getting an infection. Call your doctor right away if you have a fever, chills, flu-like symptoms, cough, pain with passing urine, or a wound that will not heal.
  • The dose and how long you need to take the medicine for depends on your specific condition and response.
  • Take Decadron (dexamethasone) in the morning with food to minimize stomach upset. If taking an evening dose, take 2-3 hours before bedtime to help you sleep better at night.
  • Decadron (dexamethasone) can cause an increase in appetite and water retention, as well as changes in mood.
  • Decadron (dexamethasone) can increase blood pressure and blood sugar with higher doses. If you have high blood pressure or diabetes, it is important that you check your blood pressure and blood sugar regularly while taking this medicine.
  • If you need to take Decadron (dexamethasone) for longer than 2 weeks, you may need to gradually stop taking this medication. Take it exactly as your doctor prescribed and do not stop suddenly.
  • Decadron (dexamethasone) can increase your chance of infection. Call your doctor right away if you have a fever, chills, flu-like signs, cough, pain with passing urine, or a wound that will not heal.
  • If inflammation or pain gets worse or lasts longer than 2 days while taking Omnipred (prednisolone acetate), talk to your doctor.
  • Only a small drop is needed per eye. Tilt your head back and place a drop into your lower eyelid, being careful not to touch the bottle tip to your eyelid or other surface. Afterwards, pinch the top of your nose (in between the eyes) for 15-30 seconds so that the liquid gets absorbed into your eyes.
  • If dose calls for multiple drops, wait 5 minutes in between each drop.
  • Shake well before use. You can store Omnipred (prednisolone acetate) at room temperature, but keeping it in the refrigerator can help alleviate symptoms of pain. Do not freeze.
  • Temporary burning and stinging in the eye may occur after putting in the drop.
  • If you are taking Omnipred (prednisolone acetate) long-term, you may need to gradually stop taking this medication. Take it exactly as your doctor prescribed and do not stop suddenly.
  • You can crush the tablets and take Cortef (Hydrocortisone) with your food or drink. Do not open up a capsule, since they need to be swallowed whole.
  • Be sure not to stop taking Cortef (Hydrocortisone) suddenly, as it can lead to loss of appetite, nausea, weakness, low blood pressure, and low blood sugar.
  • Some people gain weight while taking Cortef (Hydrocortisone). Using a weight loss program, eating smaller portions, and drinking a glass of water before meals tend to help.
Learn more
More about prednisoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Deltasone (prednisone)?
Worth itNot sureNot worth it
More about MedrolSide effectsReviews & ratingsFDA package insert
Have you used Medrol (methylprednisolone)?
Worth itNot sureNot worth it
More about dexamethasoneSide effectsReviews & ratingsFDA package insert
Have you used Decadron (dexamethasone)?
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More about prednisolone acetateSide effectsReviews & ratingsFDA package insert
Have you used Omnipred (prednisolone acetate)?
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More about CortefSide effectsReviews & ratingsFDA package insert
Have you used Cortef (hydrocortisone)?
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