Relieves menopause symptoms and lowers your risk of osteoporosis.
Our pharmacists’ bottom line
Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.
- Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
- Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
- Improves mood, energy, and mental alertness for some people.
- Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
- Doesn't affect your cholesterol levels as much as other estrogen treatments.
- More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
- Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
- Increases your risk of developing blood clots and stroke.
- You may get irregular bleeding and spotting that can last a few months to a year.
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Side effects for Prefest (Estradiol / Norgestimate)
From clinical trials of Prefest / Postmenopausal hormone replacement ( 579)
- HeadacheHeadache23% for Prefest vs.0% for placebo
- Upper respiratory-tract infectionUpper respiratory-tract infection21% for Prefest vs.0% for placebo
- Breast painBreast pain16% for Prefest vs.0% for placebo
- Back painBack pain12% for Prefest vs.0% for placebo
- Abdominal painAbdominal pain12% for Prefest vs.0% for placebo
- Flu-like symptomsa-like symptomsFlu-like symptomsa-like symptoms11% for Prefest vs.0% for placebo
- Joint painJoint pain9% for Prefest vs.0% for placebo
- Vaginal bleeding (all)Vaginal bleeding (all)9% for Prefest vs.0% for placebo
- Menstrual crampsMenstrual cramps8% for Prefest vs.0% for placebo
- Sinus inflammationSinus inflammation8% for Prefest vs.0% for placebo
What to expect when you start Prefest (Estradiol / Norgestimate)Skip what to expect section. Skip to Risks & Warnings section.
- Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
- Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
- Can cause nausea, dizziness, bloating, and breast tenderness.
- Tell your doctor about any unusual vaginal bleeding.
- Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Risks and Warnings for Prefest (Estradiol / Norgestimate)Skip Risks and Warnings section. Skip to Tips section.
- Higher risk if:
- › Using estrogen for more than one year
Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.