Prescription onlyNo lower cost generic available


(Estradiol / Norgestimate)

  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Relieves menopause symptoms and lowers your risk of osteoporosis.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyNo lower cost generic available

Our bottom line

Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.


  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.


  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.

Save on your next Prefest (Estradiol / Norgestimate) prescription

Get the lowest price for your medication, even if you have insurance.

  • (1) 30 tablets package
  • Cost for (1) 30 tablets package of Prefest (Estradiol / Norgestimate) at pharmacies

What to expect when you take Prefest (Estradiol / Norgestimate)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Prefest (Estradiol / Norgestimate)

From clinical trials of Prefest / Postmenopausal hormone replacement  ( 579)

  • HeadacheHeadache23% for Prefest vs.0% for placebo
  • Upper respiratory-tract infectionUpper respiratory-tract infection21% for Prefest vs.0% for placebo
  • Breast painBreast pain16% for Prefest vs.0% for placebo
  • Back painBack pain12% for Prefest vs.0% for placebo
  • Abdominal painAbdominal pain12% for Prefest vs.0% for placebo
  • Flu-like symptomsa-like symptomsFlu-like symptomsa-like symptoms11% for Prefest vs.0% for placebo
  • Joint painJoint pain9% for Prefest vs.0% for placebo
  • Vaginal bleeding (all)Vaginal bleeding (all)9% for Prefest vs.0% for placebo
  • Menstrual crampsMenstrual cramps8% for Prefest vs.0% for placebo
  • Sinus inflammationSinus inflammation8% for Prefest vs.0% for placebo

Risks and Warnings for Prefest (Estradiol / Norgestimate)

Skip Risks and Warnings section. Skip to Tips section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Prefest (Estradiol / Norgestimate)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is X. It is advised that you: Unsafe