Prescription onlyNo lower cost generic available

Prefest

(Estradiol / Norgestimate)

Prescription onlyNo lower cost generic available
  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
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Relieves menopause symptoms and lowers your risk of osteoporosis.

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Our bottom line

Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.

Price and discounts
  • (1) 30 tablets package
  • Cost for (1) 30 tablets package of Prefest (Estradiol / Norgestimate) at pharmacies

Upsides

  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.

Downsides

  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
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Side effect rates for Prefest (Estradiol / Norgestimate)

579 From clinical trials of Prefest / Postmenopausal hormone replacement
  • Headache
  • Upper respiratory-tract infection
  • Breast pain
  • Back pain
  • Abdominal pain
  • Flu-like symptomsa-like symptoms
  • Joint pain
  • Vaginal bleeding (all)
  • Menstrual cramps
  • Sinus inflammation

Risks and Warnings for Prefest (Estradiol / Norgestimate)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Prefest (Estradiol / Norgestimate)

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Pregnancy
Weight
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Prefest (Estradiol / Norgestimate) is a mixture of estrogen and progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.