Prescription onlyNo lower cost generic available


(Estradiol / Norgestimate)

  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
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Relieves menopause symptoms and lowers your risk of osteoporosis.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.

  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.

Save on your next Prefest (Estradiol / Norgestimate) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

  • (1) 30 tablets package
  • Cost for (1) 30 tablets package of Prefest (Estradiol / Norgestimate) at pharmacies
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Side effects for Prefest (Estradiol / Norgestimate)

From clinical trials of Prefest / Postmenopausal hormone replacement  ( 579)

  • HeadacheHeadache23% for Prefest vs.0% for placebo
  • Upper respiratory-tract infectionUpper respiratory-tract infection21% for Prefest vs.0% for placebo
  • Breast painBreast pain16% for Prefest vs.0% for placebo
  • Back painBack pain12% for Prefest vs.0% for placebo
  • Abdominal painAbdominal pain12% for Prefest vs.0% for placebo
  • Flu-like symptomsa-like symptomsFlu-like symptomsa-like symptoms11% for Prefest vs.0% for placebo
  • Joint painJoint pain9% for Prefest vs.0% for placebo
  • Vaginal bleeding (all)Vaginal bleeding (all)9% for Prefest vs.0% for placebo
  • Menstrual crampsMenstrual cramps8% for Prefest vs.0% for placebo
  • Sinus inflammationSinus inflammation8% for Prefest vs.0% for placebo

What to expect when you take Prefest (Estradiol / Norgestimate)

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Tips from our pharmacists
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.

Risks and Warnings for Prefest (Estradiol / Norgestimate)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Prefest (Estradiol / Norgestimate)

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The FDA category for this medication is X. It is advised that you: Unsafe