Prescription onlyNo lower cost generic available

Prefest Alternatives

(Estradiol / Norgestimate)

  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Prevention of postmenopausal osteoporosis
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Compare Prefest (Estradiol / Norgestimate) to alternatives

These medications are comparable to Prefest (Estradiol / Norgestimate) or used for similar purposes.

Prefest
(Estradiol / Norgestimate)

Angeliq
(Drospirenone / Estradiol)

Climara Pro
(Estradiol / Levonorgestrel Patch)

Combipatch
(Estradiol / Norethindrone Patch)

Activella
(Estradiol / Norethindrone)

Relieves menopause symptoms and lowers your risk of osteoporosis. Prefest (Estradiol / Norgestimate) is effective at treating symptoms related to menopause and bone loss. It has a difficult dosing schedule to follow, but doesn't affect your cholesterol and triglyceride levels as much as other estrogen products.Relieves hot flashes and vaginal dryness due to menopause. Angeliq (Drospirenone / Estradiol) effectively relieves menopausal symptoms. There can be many side effects, so it's important to think through the benefits and potential hassles of this drug before using it.Relieves hot flashes and lowers your risk of osteoporosis. The Climara Pro (Estradiol / Levonorgestrel Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch once a week instead of pills every day.Treats low estrogen and relieves menopause symptoms. Combipatch (Estradiol / Norethindrone Patch) is effective at treating menopause symptoms, and it can be a good choice for women who need estrogen/progestin combo medications, but prefer to use a patch every twice a week instead of pills every day.Relieves menopause symptoms and lowers your risk of osteoporosis. Activella (Estradiol / Norethindrone) is effective at treating symptoms related to menopause and preventing bone loss. The estrogen/progestin combo is a good options for women with an intact uterus.
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Side effects
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone

The Prefest FDA package insert doesn’t have numbers about how common side effects are.

More about Prefest side effects »
  • Vulvovaginal fungal infections 5%
  • Gastrointestinal and abdominal pains 3%
  • Nausea 2%
  • Breast pain 2%
  • Leg or ankle swelling 1%
  • Diarrhea 1%
  • Headache 1%
More Angeliq side effects »

The Climara Pro FDA package insert doesn’t have numbers about how common side effects are.

More about Climara Pro side effects »
  • Sore throat 8%
  • Papanicolaou smear suspicious 3%
More Combipatch side effects »
  • Excessive vaginal bleeding 14%
  • Injury accidental 13%
  • Endometrial thickening 6%
  • Back pain 6%
  • Sinus inflammation 5%
  • Common cold 3%
  • Headache 3%
  • Weight increase 3%
  • "stomach flu" 2%
  • Other events 2%
More Estradiol Norethindrone side effects »
How it works
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
Prefest (Estradiol / Norgestimate) is a combination oral medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norgestimate (a progestin) protects the uterus from damage.Angeliq (Drospirenone / Estradiol) is a combination medicine that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats, but can also harm cells in the uterus after menopause. Drospirenone (a progestin) protects the uterus from damage.Climara Pro (Estradiol / Levonorgestrel Patch) is an estrogen/progestin combo patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Levonorgestrel (a progestin) protects the uterus from damage.Combipatch (Estradiol / Norethindrone Patch) is an estrogen/progestin combination patch that works to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.Activella (Estradiol / Norethindrone) contains two hormones that work to balance hormone changes in your body during and after menopause. Estradiol (an estrogen) reduces hot flashes and night sweats and prevents bone loss, but can also harm cells in the uterus after menopause. Norethindrone (a progestin) protects the uterus from damage.
Type of medication
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
Hormone replacement
Estrogen
Progestin
Prescription only
Hormone replacement
Progestin
Estrogen
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Hormone replacement
Estrogen
Progestin
Prescription only
Available as
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
  • Pill
  • Pill
  • Patch
  • Patch
  • Pill
Used for (click to learn more)
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
  • Hot flashes and night sweats
  • Hot flashes and night sweats
  • Hot flashes and night sweats
  • Hot flashes and night sweats
  • Hot flashes and night sweats
Risk factors for serious side effects
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
  • Using estrogen for more than one year
  • Personal or family history of breast cancer
  • Duration of use
  • Personal or family history of blood clots
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • Women of childbearing age
  • High levels of triglycerides
  • Family history of ovarian cancer
Detailed Prefest (Estradiol / Norgestimate) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.No specific sleep-related info.
Weight
No specific weight-related info.
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).
No specific weight-related info.No specific weight-related info.No specific weight-related info.
Upsides and benefits
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
  • Prefest (Estradiol / Norgestimate) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good for women with an intact uterus. The norgestimate (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Doesn't affect your cholesterol levels as much as other estrogen treatments.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Angeliq (Drospirenone / Estradiol) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good for women with an intact uterus. The drospirenone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Decreased bloating and possible weight loss from the drospirenone, which has diuretic properties (helps your body get rid of water through urination).
  • Improves mood, energy, and mental alertness for some people.
  • Once-a-week patch. Good for people who don't want to take daily pills.
  • The Climara Pro (Estradiol / Levonorgestrel Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Good for women with an intact uterus. The levonorgestrel (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Twice-a-week patch. Good for people who don't want to take daily pills.
  • Combipatch (Estradiol / Norethindrone Patch) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, vaginal dryness).
  • Good for women with an intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus caused by estrogen treatment.
  • Fewer side effects than pills since patches contain lower amounts of hormones.
  • Activella (Estradiol / Norethindrone) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Good choice for women with intact uterus. The norethindrone (a progestin) protects against the risk of cancer in the uterus from estrogen treatment.
  • Mimvey brand is less expensive than other estrogen/progestin combination medicines.
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also get enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
Downsides and risks
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norgestimate (a progestin).
  • Dosing schedule can be hard to follow with the 2 different kind of pills (estrogen-only and estrogen/progestin pills).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and drospirenone (a progestin).
  • Has a slightly higher risk of blood clots compared to other estrogen-progestin combination pills because of the type of progestin it contains (drospirenone).
  • Must be used carefully with any other medicine that can increase your potassium level.
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and levonorgestrel (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects than single-ingredient medications since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
  • Patch can fall off.
  • Can be expensive since it's only available as a brand name product.
  • More potential side effects since it exposes your whole body to two hormones, estrogen and norethindrone (a progestin).
  • Increases your risk of developing blood clots and stroke.
  • You may get irregular bleeding and spotting that can last a few months to a year.
Tips from our pharmacists for people taking the medication
PrefestAngeliqClimara ProCombipatchEstradiol Norethindrone
  • Follow the dosing schedule exactly to take the estrogen-only and combination estrogen/progestin pills.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • You can get some bleeding if you miss several doses in a row.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Replace the patch weekly on a different area of your skin to lower your risk of skin irritation.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Replace the patch twice a week (every 3-4 days) on a different area of your skin to lower your risk of skin irritation.
  • Remove the patch by tearing the package by hand and not with scissors. Never cut the patch.
  • Apply the sticky side of the patch to clean, dry, hairless skin below your waistline on areas as instructed by the manufacturer (never on your breast).
  • Fold together the sticky sides of used patches before throwing them away to avoid exposing others to the medicine. Don't flush them down the toilet.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
  • Shouldn't be used forever. Talk to your doctor regularly to see if you still need treatment.
  • Can cause nausea, dizziness, bloating, and breast tenderness.
  • Tell your doctor about any unusual vaginal bleeding.
  • Get emergency care if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision.
Learn more
More about PrefestSide effectsAlternativesFDA package insert
More about AngeliqSide effectsFDA package insert
More about Climara ProSide effectsReviews & ratingsFDA package insert
More about CombipatchSide effectsReviews & ratingsFDA package insert
More about Estradiol NorethindroneSide effectsReviews & ratingsFDA package insert