Prescription onlyLower-cost generic availableClass: Women's health

Premarin

(conjugated estrogens)

Prescription onlyLower-cost generic availableClass: Women's health
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4.78Premarin

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Our bottom line

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

Prices and discounts
Lowest price for 30 0.625mg tablets
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$165.77

Upsides

  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
People’s experience with Premarin

154reviews so far. What do you think?

Worth itNot sureNot worth it

Downsides

  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
Prices and discounts
Lowest price for 30 0.625mg tablets
Determining your location...
$165.77
How it works

Premarin (Conjugated Estrogens) is an oral medication that replaces estrogen hormones during and after menopause. Higher levels of estrogen lower menopause-related hot flashes, flushing, night sweats, vaginal problems, and bone loss.

People’s experience with Premarin

154reviews so far. What do you think?

Worth itNot sureNot worth it
Used for
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
Dosage forms
  • Pill
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Side effect rates for Premarin (conjugated estrogens)

658 From clinical trials of Premarin / Estrogen replacement postmenopause (0.3 mg)
  • Headache
  • Abdominal pain
  • Breast pain
  • Nausea
  • Vaginal moniliasis
  • Back pain
  • Asthenia
  • Flatulence
  • Pain
  • Insomnia

Risks and Warnings for Premarin (conjugated estrogens)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Premarin (conjugated estrogens)

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Pregnancy
Price
  • The price is too high. I take it daily and have for over 20 years. Without Premarin I have severe hot flashes day and night. I also have mood swings.
Pain
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
Weight
  • Can cause nausea, dizziness, bloating and breast tenderness.