Prescription onlyLower-cost generic available

Premarin

(Conjugated Estrogens)

Prescription onlyLower-cost generic available
  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
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Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

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Our bottom line

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

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Upsides

  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
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Downsides

  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.
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Side effect rates for Premarin (Conjugated Estrogens)

658 From clinical trials of Premarin / Estrogen replacement postmenopause (0.3 mg)
  • Headache
  • Abdominal pain
  • Breast pain
  • Nausea
  • Thick vaginal discharge
  • Vaginal moniliasis
  • Pain
  • Sleep difficulty
  • Muscle weakness
  • Passing gas

Risks and Warnings for Premarin (Conjugated Estrogens)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Premarin (Conjugated Estrogens)

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Pregnancy
Pain
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
Weight
  • Can cause nausea, dizziness, bloating and breast tenderness.