Prescription onlyLower-cost generic available


(Conjugated Estrogens)

  • Pill
  • Hot flashes and night sweats
  • Vaginal dryness and inflammation
  • Low estrogen
  • Primary ovarian failure
  • Prevention of postmenopausal osteoporosis
  • Metastatic breast cancer
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Treats low estrogen, relieves menopause symptoms, and lowers your risk of osteoporosis.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Premarin (Conjugated Estrogens) relieves menopausal symptoms and prevents bone loss. It's an oral hormone replacement, so it can have a lot of side effects, and it's important to think through the benefits and potential hassles of this drug before using it.

Worth it?Is it worth it?
Effectiveness?Is it effective?
Hassle?Is it a hassle?
  • Premarin (Conjugated Estrogens) replenishes estrogen to your whole body and relieves multiple symptoms due to low estrogen (hot flashes, night sweats, vaginal dryness).
  • Lowers your risk of fractures by keeping your bones healthy. Make sure you also take enough calcium and Vitamin D.
  • Improves mood, energy, and mental alertness for some people.
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.
  • Can help relieve symptoms of prostate cancer or advanced breast cancer in some people.
  • More potential side effects than estrogen creams since it exposes your whole body to estrogen.
  • Increases your risk of uterine and breast cancer.
  • If you have your uterus, you have to take Premarin (Conjugated Estrogens) with another hormone called progestin to lower your risk of uterine cancer.
  • Increases your risk of developing blood clots and stroke.
  • Can't be used in people with liver problems.
  • Can be expensive since it's only available as a brand name product.

Save on your next Premarin (Conjugated Estrogens) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Premarin (Conjugated Estrogens)

From clinical trials of Premarin / Estrogen replacement postmenopause (0.3 mg) ( 658)

  • HeadacheHeadache13% for Premarin vs.14% for placebo
  • Abdominal painAbdominal pain9% for Premarin vs.6% for placebo
  • Breast painBreast pain7% for Premarin vs.8% for placebo
  • NauseaNausea5% for Premarin vs.5% for placebo
  • Thick vaginal dischargeThick vaginal discharge4% for Premarin vs.2% for placebo
  • Vaginal moniliasisVaginal moniliasis4% for Premarin vs.2% for placebo
  • Back painBack pain4% for Premarin vs.1% for placebo
  • PainPain4% for Premarin vs.4% for placebo
  • Sleep difficultySleep difficulty4% for Premarin vs.4% for placebo
  • Muscle weaknessMuscle weakness4% for Premarin vs.1% for placebo

Manufacturers don’t say how common these side effects are

  • Increased appetite
  • Migraine
  • Rash
  • Urinary tract infection
  • Vaginal dryness

What to expect when you start Premarin (Conjugated Estrogens)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • Take Premarin (Conjugated Estrogens) at the same time each day. If you miss a dose, take it as soon as possible, but if it’s almost time for your next dose, take only that dose.
  • Use the lowest dose possible of Premarin (Conjugated Estrogens) and take it only as long as needed. Talk to your doctor regularly to see if you still need treatment. If you’re taking Premarin (Conjugated Estrogens) only for vaginal symptoms or to prevent bone loss, there are other medicines that can work better with fewer side effects (like a vaginal cream for menopause symptoms, or non-estrogen medicine for bone loss).
  • Can cause nausea, dizziness, bloating and breast tenderness.
  • Get emergency care if you notice swelling or pain in your lower legs, sudden shortness of breath, or an unexplained severe headache.
  • Tell your doctor about any unusual vaginal bleeding.

Risks and Warnings for Premarin (Conjugated Estrogens)

Skip Risks and Warnings section. Skip to Tips section.
    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Premarin (Conjugated Estrogens)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is X. It is advised that you: Unsafe
  • Upsides and downsides from our pharmacists
  • Does not expose your partner to estrogen during sexual acitivities like vaginal estrogen creams.