Prescription onlyNo lower cost generic available

Premarin Vaginal Cream

(Conjugated Estrogens)

  • Vaginal cream, gel, or ointment
  • Vaginal dryness and inflammation
  • Painful intercourse from menopause
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Relieves vaginal dryness and pain due to menopause.

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Prescription onlyNo lower cost generic available

Our pharmacists’ bottom line

Premarin Vaginal Cream (Conjugated Estrogens) works well for vaginal problems caused by menopause, and it has fewer side effects than estrogen pills.

  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • Works locally in the vagina and doesn't expose the rest of your body to estrogen like pills do.
  • Premarin Vaginal Cream (Conjugated Estrogens) doesn't need to be used forever, so you can work with your doctor to see how long you’ll need to continue treatment.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).
  • Vaginal estrogens can weaken latex (rubber) condoms, cervical caps, and diaphragms, so you can't rely on these for birth control for 72 hours after using Premarin Vaginal Cream (Conjugated Estrogens).
  • If you have severe vaginal dryness, you might have pain, bleeding, or infections from repeatedly inserting the applicator.
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Even though Premarin Vaginal Cream (Conjugated Estrogens) is used in the vagina, it's possible some of the estrogens will get into the rest of your body and cause side effects that happen more often with estrogen pills.
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Side effects for Premarin Vaginal Cream (Conjugated Estrogens)

From clinical trials of Premarin Vaginal Cream / Symptoms associated with menopause (.3 mg) ( 658)

  • Any side effectAny side effect90% for Premarin cream vs.85% for placebo
  • HeadacheHeadache28% for Premarin cream vs.28% for placebo
  • InfectionInfection23% for Premarin cream vs.22% for placebo
  • PainPain20% for Premarin cream vs.18% for placebo
  • Abdominal painAbdominal pain17% for Premarin cream vs.11% for placebo
  • Back painBack pain13% for Premarin cream vs.12% for placebo
  • Sore throatSore throat12% for Premarin cream vs.11% for placebo
  • IndigestionIndigestion11% for Premarin cream vs.14% for placebo
  • Inflammation inside the noseInflammation inside the nose10% for Premarin cream vs.13% for placebo
  • Flu syndromeFlu syndrome10% for Premarin cream vs.11% for placebo

What to expect when you take Premarin Vaginal Cream (Conjugated Estrogens)

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Tips from our pharmacists
  • Your doctor will tell you how often to use Premarin Vaginal Cream (Conjugated Estrogens). If you're taking Premarin Vaginal Cream (Conjugated Estrogens) regularly, use it around the same time each day.
  • Attach the applicator to the tube. Once the dose is measured, insert the applicator deeply into your vagina, and press the plunger to release all the medicine. Clean the applicator after each use.
  • More effective if you use it at bedtime.
  • Consider wearing a panty liner after use.
  • Most people don't have many side effects, but temporary nausea, dizziness, bloating, and breast tenderness are possible.

Risks and Warnings for Premarin Vaginal Cream (Conjugated Estrogens)

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    • Higher risk if:
    • Using estrogen for more than one year

    Vaginal bleeding after menopause can be a warning sign of uterus (endometrial) cancer, so let your doctor know if you notice any unusual bleeding. When estrogen is prescribed to women after menopause who still have a uterus, progestin should be used with it to lower the risk of cancer. Low-dose vaginal estrogen products are often a better choice than oral pills for women 65 years or older who have vaginal symptoms.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Premarin Vaginal Cream (Conjugated Estrogens)

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The FDA category for this medication is X. It is advised that you: Unsafe
Pregnancy
Sex
  • Upsides and downsides from our pharmacists
  • Some of the medicine can be absorbed into your partner's skin, so you can’t have vaginal sex right after using Premarin Vaginal Cream (Conjugated Estrogens).
  • Premarin Vaginal Cream (Conjugated Estrogens) relieves vaginal dryness and irritation to make sex more enjoyable.
  • For painful sex, it can work better than over-the-counter vaginal lubricants because Premarin Vaginal Cream (Conjugated Estrogens) treats the cause of the problem (low estrogen levels), not just the symptoms (dryness).