Pristiq

(Desvenlafaxine)

3.5/ 5 average rating with 196 reviewsforPristiq
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Improves mood.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

Quick facts about Pristiq
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (desvenlafaxine)
Prices and discounts
Lowest price for 30 50mg tablets
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$383.51

Upsides

  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.

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What to expect from Pristiq, on one page

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People’s experience with Pristiq

196reviews so far. What do you think?

Downsides

  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.

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Get our free fact sheet

What to expect from Pristiq, on one page

Download Fact Sheet
Prices and discounts
Lowest price for 30 50mg tablets
Determining your location...
$383.51
How it works

Pristiq (Desvenlafaxine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.

Quick facts about Pristiq
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (desvenlafaxine)

Dosage forms

  • Extended release
People’s experience with Pristiq

196reviews so far. What do you think?

What to expect when you take Pristiq (Desvenlafaxine) for Depression

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Skip side effects section. Skip to risks and warnings section.

Side effect rates for Pristiq (Desvenlafaxine)

From 953 clinical trials of Pristiq when taken for major depressive disorder (50 mg)
  • Nausea
  • Dizziness
  • Dry mouth
  • Hyperhidrosis
  • Constipation
  • Insomnia
  • Fatigue
  • Decreased appetite
  • Somnolence
  • Vomiting

Risks and Warnings for Pristiq (Desvenlafaxine)

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    • Higher risk if:
    • Age 24 years or younger

    Pristiq (Desvenlafaxine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Pristiq (Desvenlafaxine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Pristiq (Desvenlafaxine)

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Pregnancy
Price
  • Reviewed Pristiqon 8/28/2015Avoid withdrawal at ALL COSTS. Vivid nightmares, migraines and insane mood swings. I take 100mg 1x 24/7 with buspirone. It was effective in the beginning, but has tapered off. I would suggest another medication before this one.
    23
    Woman
    Two years or more
    Depression
Alcohol
  • Reviewed Pristiqon 3/22/2017Alcohol definitely has a stronger effect on this medication. I am usually pretty warm compared to before I started this medication and sweating happens relatively easy. Occasionally, I feel jittery, get hot flashes, or have ringing in my ears. I also noticed I yawn more during physical activity.
    21
    Man
    A few months
    Depression
Food
  • Reviewed Pristiqon 8/18/2017Don't take it before bed. Take it in the morning around lunch for best results
    19
    Woman
    Two years or more
    Depression
Pain
  • Reviewed Pristiqon 1/22/2016Do not miss. Back of your neck hurts and it feels as if little electrical shocks are going up into your brain. Take it at the same time every day. It saved me. Period.
    48
    Man
    Two years or more
Sleep
  • Reviewed Pristiqon 12/28/2016Definitely take in the morning. I had no drowsiness, but rather felt more alert. I couldn't sleep when taken in the evening. Uptake is practically nonexistent with 50mg being both a starting and therapeutic dose. Took about a week and half for noticeable change. Within a month, great benefit along side psychological talk therapy.
    22
    Woman
    Depression
Weight
  • Reviewed Pristiqon 10/7/2016Although this is supposed to be weight neutral I gained 15lbs in 4 months. I was constantly hungry and bloated. Some of this could have been due to the Extreme APATHY I encountered on this medicine. It reduced the extreme anxiety encountered while being unemployed and I can say it did help turn that around, but almost to an extreme point of apathetic procrastination & Fatigue.
    40
    Man
    Depression