Prescription onlyNo lower cost generic available


(Progesterone Vaginal Gel)

  • Vaginal cream, gel, or ointment
  • Female infertility
  • Amenorrhea
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Regulates your menstrual cycle and supports fertility treatments.

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Prescription onlyNo lower cost generic available

Our bottom line

Crinone (Progesterone Vaginal Gel) is a long-acting vaginal gel used in fertility treatments, and you don't have to apply it as often as progesterone vaginal inserts.


  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Crinone (Progesterone Vaginal Gel) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg. If you become pregnant, Crinone (Progesterone Vaginal Gel) can be used for another 10 to 12 weeks until your progesterone levels are high enough.
  • Women can also use Crinone (Progesterone Vaginal Gel) to treat secondary amenorrhea (the absence of menstrual cycles in women who used to have a regular period) due to a decrease in the hormone progesterone. Crinone (Progesterone Vaginal Gel) is used to bring the hormone levels back up to normal.


  • Crinone (Progesterone Vaginal Gel) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Crinone (Progesterone Vaginal Gel) can cause a white vaginal discharge a few days after taking the medicine, so wearing a panty liner can make you feel more comfortable.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Crinone (Progesterone Vaginal Gel).
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What to expect when you take Crinone (Progesterone Vaginal Gel)

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Tips from our pharmacists
  • Read the information you get at your pharmacy about how to use Crinone (Progesterone Vaginal Gel). The diagrams are really helpful and there are different instructions for women using the gel at high altitudes.
  • The dose of Crinone (Progesterone Vaginal Gel) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Crinone (Progesterone Vaginal Gel) is available as a vaginal gel in two different strengths, 4% and 8%. Using more of the 4% gel isn't the same as using the 8% strength.
  • Each vaginal gel applicator is made for a single use and should be thrown away after you use it. Don't worry if a small amount of gel is left in the applicator.
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Side effects for Crinone (Progesterone Vaginal Gel)

From clinical trials of Progesterone vaginal gel / Amenorrhea (4% gel)  ( 62)

  • Mood swingsMood swings23% for Progesterone gel vs.0% for placebo
  • FatigueFatigue21% for Progesterone gel vs.0% for placebo
  • Cramps nosCramps nos19% for Progesterone gel vs.0% for placebo
  • HeadacheHeadache19% for Progesterone gel vs.0% for placebo
  • Low mood disorderLow mood disorder19% for Progesterone gel vs.0% for placebo
  • Sleep disorderSleep disorder18% for Progesterone gel vs.0% for placebo
  • BloatingBloating13% for Progesterone gel vs.0% for placebo
  • Vaginal dischargeVaginal discharge11% for Progesterone gel vs.0% for placebo
  • Muscle painMuscle pain8% for Progesterone gel vs.0% for placebo
  • Back painBack pain8% for Progesterone gel vs.0% for placebo

Risks and Warnings for Crinone (Progesterone Vaginal Gel)

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    • Higher risk if:
    • Personal or family history of breast cancer

    It is not completely clear if progestin, like as Crinone (Progesterone Vaginal Gel), increases your risk of breast cancer. There may be a higher risk if you have a history of breast cancer, so make sure to get routine breast exams.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Crinone (Progesterone Vaginal Gel)

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The FDA category for this medication is N. It is advised that you: Unknown