Prescription onlyClass: Women's health


(progesterone vaginal gel)

Prescription onlyClass: Women's health
Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Common concerns from users and pharmacists

Regulates your menstrual cycle and supports fertility treatments.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Crinone (Progesterone Vaginal Gel) is a long-acting vaginal gel used in fertility treatments, and you don't have to apply it as often as progesterone vaginal inserts.

No pricing data for this drug at this filter setting. Try searching onGoodRx


  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Crinone (Progesterone Vaginal Gel) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg. If you become pregnant, Crinone (Progesterone Vaginal Gel) can be used for another 10 to 12 weeks until your progesterone levels are high enough.
  • Women can also use Crinone (Progesterone Vaginal Gel) to treat secondary amenorrhea (the absence of menstrual cycles in women who used to have a regular period) due to a decrease in the hormone progesterone. Crinone (Progesterone Vaginal Gel) is used to bring the hormone levels back up to normal.


  • Crinone (Progesterone Vaginal Gel) can cause vaginal irritation and burning.
  • Inserting the applicator can possibly cause discomfort or infection.
  • Crinone (Progesterone Vaginal Gel) can cause a white vaginal discharge a few days after taking the medicine, so wearing a panty liner can make you feel more comfortable.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Crinone (Progesterone Vaginal Gel).
How it works

Crinone (Progesterone Vaginal Gel) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.

Skip side effects section. Skip to What to Expect and Pharmacists Tips section.

Side effect rates for Crinone (progesterone vaginal gel)

62 From clinical trials of Progesterone Vaginal Gel / Amenorrhea (4% gel)
  • Mood swings
  • Fatigue
  • Cramps nos
  • Headache
  • Low mood disorder
  • Sleep disorder
  • Bloating
  • Vaginal discharge
  • Muscle pain
  • Back pain

Risks and Warnings for Crinone (progesterone vaginal gel)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Personal or family history of breast cancer

    It is not completely clear if progestin, like as Crinone (Progesterone Vaginal Gel), increases your risk of breast cancer. There may be a higher risk if you have a history of breast cancer, so make sure to get routine breast exams.

Common concerns from people taking Crinone (progesterone vaginal gel)

Final section. Do you want to return to drug navigation?
  • Crinone (Progesterone Vaginal Gel) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.