Prescription onlyClass: Women's health

Crinone Alternatives

(Progesterone Vaginal Gel)

Prescription onlyClass: Women's health
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Compare Crinone (Progesterone Vaginal Gel) to alternatives

These medications are comparable to Crinone (Progesterone Vaginal Gel) or used for similar purposes.

Crinone
(Progesterone Vaginal Gel)

Endometrin
(Progesterone Vaginal Insert)

Aygestin
(Norethindrone)

Prometrium
(Progesterone)

Provera
(Medroxyprogesterone)

Regulates your menstrual cycle and supports fertility treatments. Crinone (Progesterone Vaginal Gel) is a long-acting vaginal gel used in fertility treatments, and you don't have to apply it as often as progesterone vaginal inserts.Supports fertility treatments. Endometrin (Progesterone Vaginal Insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.Regulates your menstrual cycle and treats irregular bleeding. Aygestin (Norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.Taken for irregular bleeding or paired with estrogen replacements for menopause. Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
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Reviews & ratings
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Have you used Crinone (Progesterone Vaginal Gel)?
Worth itNot sureNot worth it
Reviews for Endometrin (Progesterone Vaginal Insert)
45%
+45% better vs. Crinone (Progesterone Vaginal Gel)
20%
+20% better vs. Crinone (Progesterone Vaginal Gel)
27%
-27% worse vs. Crinone (Progesterone Vaginal Gel)
Have you used Endometrin (Progesterone Vaginal Insert)?
Worth itNot sureNot worth it
Reviews for Aygestin (Norethindrone)
40%
+40% better vs. Crinone (Progesterone Vaginal Gel)
23%
+23% better vs. Crinone (Progesterone Vaginal Gel)
23%
-23% worse vs. Crinone (Progesterone Vaginal Gel)
Have you used Aygestin (Norethindrone)?
Worth itNot sureNot worth it
Reviews for Prometrium (Progesterone)
61%
+61% better vs. Crinone (Progesterone Vaginal Gel)
41%
+41% better vs. Crinone (Progesterone Vaginal Gel)
17%
-17% worse vs. Crinone (Progesterone Vaginal Gel)
Have you used Prometrium (Progesterone)?
Worth itNot sureNot worth it

Not enough reviews for this drug. Help someone out, leave a review!

Have you used Provera (Medroxyprogesterone)?
Worth itNot sureNot worth it
Side effects
Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
  • Cramps 15%
  • Headache 13%
  • Breast pain 13%
  • Pain 8%
  • Bloating 7%
  • Nausea 7%
  • Vaginal discharge 7%
  • Dizziness 5%
  • Moniliasis genital 5%
  • Pruritus genital 5%
More Progesterone Vaginal Gel side effects »
  • Post-oocyte retrieval pain 28%
  • Abdominal pain 12%
  • Nausea 8%
  • Ovarian hyperstimulation syndrome 7%
  • Headache 4%
  • Abdominal distension 4%
  • Uterine spasm 4%
  • Vomiting 3%
  • Vaginal bleeding 3%
More Endometrin side effects »

The Aygestin FDA package insert doesn’t have numbers about how common side effects are.

More about Aygestin side effects »
  • Headache 4%
  • Breast tenderness 21%
  • Low mood disorder 7%
  • Dizziness 6%
  • Abdominal bloating 7%
  • Urinary problems 2%
  • Vaginal discharge 7%
More Prometrium side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
Crinone (Progesterone Vaginal Gel) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.Endometrin (Progesterone Vaginal Insert) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.Aygestin (Norethindrone) contains norethindrone, a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).Prometrium (Progesterone) contains progesterone, a hormone that regulates the menstrual cycle and protects the uterus from the negative effects of estrogen when used for postmenopausal treatment.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
Prescription only
Prescription only
Prescription only
Prescription only
Prescription only
Available as
Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
  • Vaginal cream, gel, or ointment
  • Vaginal insert
  • Pill
  • Pill
  • Injection
  • Pill
Used for
Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
  • Female Infertility
  • Female Infertility
  • Pain Caused By Endometriosis
  • Amenorrhea
  • Amenorrhea
Risk factors for serious side effects
Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • Diabetes
  • Heart failure
  • Kidney problems
  • Obesity
Detailed Crinone (Progesterone Vaginal Gel) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • Diabetes
  • Heart failure
  • Kidney problems
  • Obesity
Detailed Endometrin (Progesterone Vaginal Insert) risks & warnings »
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Systemic lupus erythematosus (SLE)
    • History of depression
    • Diabetes
    • History of liver problems
    • High cholesterol levels
    Detailed Aygestin (Norethindrone) risks & warnings »
    • Personal or family history of breast cancer
    • Family history of ovarian cancer
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
    • Allergy to peanuts
    • Heart failure
    • Kidney problems
    • Obesity
    • History of depression
    Detailed Prometrium (Progesterone) risks & warnings »
    • Personal or family history of breast cancer
    • Family history of ovarian cancer
    • Personal or family history of blood clots
    • Smoking
    • Obesity
    • Hypertension
    • Diabetes
    • High cholesterol
    • Systemic lupus erythematosus (SLE)
    • History of depression
    • History of liver problems
    • Women of childbearing age
    Detailed Provera (Medroxyprogesterone) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

    Kidneys and liver
    Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
    No kidneys and liver related info.No kidneys and liver related info.
    • Aygestin (Norethindrone) is broken down by the liver, so if the liver is damaged, the drug can build up in your body. Tell your doctor if you've had liver disease or damage. Your doctor will have to change Aygestin (Norethindrone) to a different medicine.
    No kidneys and liver related info.No kidneys and liver related info.
    Pain
    Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
    No pain related info.No pain related info.
    • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
    • Aygestin (Norethindrone) can raise your risk of blood clots, which can be very dangerous. You're more likely to have them if you smoke tobacco, are obese, or if you or your family have ever had blood clots. Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.
    • Relives pain from endometriosis.
    • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
    No pain related info.
    Weight
    Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
    • Crinone (Progesterone Vaginal Gel) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
    • Endometrin (Progesterone Vaginal Insert) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
    • Can make you gain weight.
    • Aygestin (Norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
    • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
    • Prometrium (Progesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
    Upsides and benefits
    Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
    • Helps increase your chances of getting pregnant.
    • Regulates your menstrual cycle.
    • Exposes your body to less hormone compared to progesterone pills or injections.
    • Crinone (Progesterone Vaginal Gel) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg. If you become pregnant, Crinone (Progesterone Vaginal Gel) can be used for another 10 to 12 weeks until your progesterone levels are high enough.
    • Women can also use Crinone (Progesterone Vaginal Gel) to treat secondary amenorrhea (the absence of menstrual cycles in women who used to have a regular period) due to a decrease in the hormone progesterone. Crinone (Progesterone Vaginal Gel) is used to bring the hormone levels back up to normal.
    • Helps increase your chances of getting pregnant.
    • Regulates your menstrual cycle.
    • Exposes your body to less hormone compared to progesterone pills or injections.
    • Endometrin (Progesterone Vaginal Insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
    • Endometrin (Progesterone Vaginal Insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that make you to lie down when inserting them, Endometrin (Progesterone Vaginal Insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
    • Helps to regulate your period.
    • Decreases bleeding from hormone imbalance.
    • Available as a generic medication, so it costs less.
    • Helps to regulate your menstrual cycle.
    • Relives pain from endometriosis.
    • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
    • Available as a capsule or an injection, so you can choose what works best for you.
    • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
    • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
    • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
    Downsides and risks
    Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
    • Crinone (Progesterone Vaginal Gel) can cause vaginal irritation and burning.
    • Inserting the applicator can possibly cause discomfort or infection.
    • Crinone (Progesterone Vaginal Gel) can cause a white vaginal discharge a few days after taking the medicine, so wearing a panty liner can make you feel more comfortable.
    • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Crinone (Progesterone Vaginal Gel).
    • Endometrin (Progesterone Vaginal Insert) can cause vaginal irritation and burning.
    • Inserting the applicator can possibly cause discomfort or infection.
    • Endometrin (Progesterone Vaginal Insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
    • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after taking Endometrin (Progesterone Vaginal Insert).
    • Can make you gain weight.
    • Higher risk of blood clots.
    • Not for people who are post-menopausal, pregnant, or breast-feeding.
    • Can cause a lot of side effects.
    • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
    • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
    • Increases your risk of blood clots.
    • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
    Tips from our pharmacists for people taking the medication
    Progesterone Vaginal GelEndometrinAygestinPrometriumProvera
    • Read the information you get at your pharmacy about how to use Crinone (Progesterone Vaginal Gel). The diagrams are really helpful and there are different instructions for women using the gel at high altitudes.
    • The dose of Crinone (Progesterone Vaginal Gel) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
    • Crinone (Progesterone Vaginal Gel) is available as a vaginal gel in two different strengths, 4% and 8%. Using more of the 4% gel isn't the same as using the 8% strength.
    • Each vaginal gel applicator is made for a single use and should be thrown away after you use it. Don't worry if a small amount of gel is left in the applicator.
    • Read the information you get in the pharmacy about how to use Endometrin (Progesterone Vaginal Insert). The step-by-step instructions are really helpful to follow.
    • Each vaginal insert applicator is made for a single use and should be thrown away after you use it.
    • The dose of Aygestin (Norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
    • It's important to take it at the same time every day.
    • Talk to your doctor every few months about using the lowest possible dose of Aygestin (Norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
    • If you're taking Aygestin (Norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (Norethindrone).
    • Aygestin (Norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
    • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
    • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
    • It's important to take it the same time every day.
    • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
    • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
    • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
    • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
    • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
    • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
    • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
    • Can cause headache, weight gain, breast tenderness, or changes in mood.
    • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
    Learn more
    More about Progesterone Vaginal GelSide effectsAlternativesFDA package insert
    Have you used Crinone (Progesterone Vaginal Gel)?
    Worth itNot sureNot worth it
    More about EndometrinSide effectsReviews & ratingsFDA package insert
    Have you used Endometrin (Progesterone Vaginal Insert)?
    Worth itNot sureNot worth it
    More about AygestinSide effectsReviews & ratingsFDA package insert
    Have you used Aygestin (Norethindrone)?
    Worth itNot sureNot worth it
    More about PrometriumSide effectsReviews & ratingsFDA package insert
    Have you used Prometrium (Progesterone)?
    Worth itNot sureNot worth it
    More about ProveraSide effectsReviews & ratingsFDA package insert
    Have you used Provera (Medroxyprogesterone)?
    Worth itNot sureNot worth it