Prescription onlyNo lower cost generic available

Crinone Alternatives

(Progesterone Vaginal Gel)

  • Vaginal cream, gel, or ointment
  • Female infertility
  • Amenorrhea
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Compare Crinone (Progesterone Vaginal Gel) to alternatives

These medications are comparable to Crinone (Progesterone Vaginal Gel) or used for similar purposes.

Crinone
(Progesterone Vaginal Gel)

Endometrin
(Progesterone Vaginal Insert)

Aygestin
(Norethindrone)

Prometrium
(Progesterone)

Provera
(Medroxyprogesterone)

Regulates your menstrual cycle and supports fertility treatments. Crinone (Progesterone Vaginal Gel) is a long-acting vaginal gel used in fertility treatments, and you don't have to apply it as often as progesterone vaginal inserts.Supports fertility treatments. Endometrin (Progesterone Vaginal Insert) is a vaginal insert used in fertility treatments, but you have to apply it more often than progesterone vaginal gel.Regulates your menstrual cycle and treats irregular bleeding. Aygestin (Norethindrone) regulates the menstrual cycle and treats heavy vaginal bleeding. It's easy to take and isn't expensive.Taken for irregular bleeding or paired with estrogen replacements for menopause. Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
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Reviews & ratings
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Reviews for Endometrin (Progesterone Vaginal Insert)
45%
+45% vs. Crinone (Progesterone Vaginal Gel)
20%
+20% vs. Crinone (Progesterone Vaginal Gel)
27%
27% vs. Crinone (Progesterone Vaginal Gel)
Reviews for Aygestin (Norethindrone)
40%
+40% vs. Crinone (Progesterone Vaginal Gel)
23%
+23% vs. Crinone (Progesterone Vaginal Gel)
23%
23% vs. Crinone (Progesterone Vaginal Gel)
Reviews for Prometrium (Progesterone)
62%
+62% vs. Crinone (Progesterone Vaginal Gel)
41%
+41% vs. Crinone (Progesterone Vaginal Gel)
16%
16% vs. Crinone (Progesterone Vaginal Gel)

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
Progesterone vaginal gelEndometrinAygestinPrometriumProvera

The Progesterone vaginal gel FDA package insert doesn’t have numbers about how common side effects are.

More about Progesterone vaginal gel side effects »

The Endometrin FDA package insert doesn’t have numbers about how common side effects are.

More about Endometrin side effects »

We haven’t found good data for Aygestin side effects.

FDA side effect reports for Aygestin »
  • Breast tenderness 21%
  • Dizziness 20%
  • Breast pain 8%
  • Musculoskeletal pain 8%
  • Low mood disorder 7%
  • Abdominal pain (cramping) 7%
  • Vaginal discharge 7%
  • Abdominal bloating 7%
  • Worry 4%
  • Irritability 4%
More Prometrium side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
Crinone (Progesterone Vaginal Gel) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.Endometrin (Progesterone Vaginal Insert) contains progesterone, one of the hormones essential for maintaining a pregnancy. Women on fertility treatment can take progesterone to prepare the lining of the uterus to receive and nourish a fertilized egg.Aygestin (Norethindrone) contains norethindrone, a progestin, which is a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).Prometrium (Progesterone) contains progesterone, a hormone that regulates the menstrual cycle and protects the uterus from the negative effects of estrogen when used for postmenopausal treatment.Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
ProgestinPrescription only
ProgestinPrescription only
ProgestinPrescription only
ProgestinPrescription only
Hormone replacement
Progestin
Prescription only
Available as
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
  • Vaginal cream, gel, or ointment
  • Vaginal insert
  • Pill
  • Pill
  • Injection
  • Pill
Used for (click to learn more)
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
  • Female infertility
  • Female infertility
  • Amenorrhea
  • Amenorrhea
  • Amenorrhea
Risk factors for serious side effects
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Hypertension
  • Diabetes
  • High cholesterol
  • Systemic lupus erythematosus (SLE)
  • Diabetes
  • Heart failure
  • Kidney problems
  • Obesity
Detailed Crinone (Progesterone Vaginal Gel) risks & warnings »
Coming soon.Coming soon.Coming soon.Coming soon.
Pregnancy category
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
BFDA pregnancy category (Probably safe)

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

See the FDA package insert
XFDA pregnancy category (Unsafe)

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.No specific alcohol-related info.
Food
No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.No specific sex-related info.
Sleep
No specific sleep-related info.No specific sleep-related info.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
  • Can make you gain weight.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
Upsides and benefits
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
  • Crinone (Progesterone Vaginal Gel) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg. If you become pregnant, Crinone (Progesterone Vaginal Gel) can be used for another 10 to 12 weeks until your progesterone levels are high enough.
  • Women can also use Crinone (Progesterone Vaginal Gel) to treat secondary amenorrhea (the absence of menstrual cycles in women who used to have a regular period) due to a decrease in the hormone progesterone. Crinone (Progesterone Vaginal Gel) is used to bring the hormone levels back up to normal.
  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Endometrin (Progesterone Vaginal Insert) replaces low levels of progesterone to prepare the lining of your uterus to receive and nourish a fertilized egg.
  • Endometrin (Progesterone Vaginal Insert) comes with step-by-step instructions and is easy to use. Unlike some progesterone products that make you to lie down when inserting them, Endometrin (Progesterone Vaginal Insert) can be inserted while you are standing, sitting, or lying on your back with your knees bent.
  • Helps increase your chances of getting pregnant.
  • Regulates your menstrual cycle.
  • Exposes your body to less hormone compared to progesterone pills or injections.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Aygestin (Norethindrone) is available as a generic medication, so it costs less.
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
Downsides and risks
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
  • Crinone (Progesterone Vaginal Gel) can cause vaginal irritation and burning.
  • Crinone (Progesterone Vaginal Gel) can cause a white vaginal discharge a few days after taking the medicine, so wearing a panty liner can make you feel more comfortable.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after using Crinone (Progesterone Vaginal Gel).
  • Inserting the applicator can possibly cause discomfort or infection.
  • Endometrin (Progesterone Vaginal Insert) can cause vaginal irritation and burning.
  • Endometrin (Progesterone Vaginal Insert) is dosed 2 to 3 times a day, compared to other progesterone products that are dosed 1 to 2 times a day.
  • You can't use tampons or other vaginal products for at least 6 hours before and 6 hours after taking Endometrin (Progesterone Vaginal Insert).
  • Inserting the applicator can possibly cause discomfort or infection.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
Tips from our pharmacists for people taking the medication
Progesterone vaginal gelEndometrinAygestinPrometriumProvera
  • Read the information you get at your pharmacy about how to use Crinone (Progesterone Vaginal Gel). The diagrams are really helpful and there are different instructions for women using the gel at high altitudes.
  • The dose of Crinone (Progesterone Vaginal Gel) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Crinone (Progesterone Vaginal Gel) is available as a vaginal gel in two different strengths, 4% and 8%. Using more of the 4% gel isn't the same as using the 8% strength.
  • Each vaginal gel applicator is made for a single use and should be thrown away after you use it. Don't worry if a small amount of gel is left in the applicator.
  • Read the information you get in the pharmacy about how to use Endometrin (Progesterone Vaginal Insert). The step-by-step instructions are really helpful to follow.
  • Each vaginal insert applicator is made for a single use and should be thrown away after you use it.
  • The dose of Aygestin (Norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (Norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (Norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (Norethindrone).
  • It's important to take it the same time every day.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
  • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
  • It's important to take it the same time every day.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
Learn more
More about Progesterone vaginal gelSide effectsAlternativesFDA package insert
More about EndometrinSide effectsReviews & ratingsFDA package insert
More about AygestinSide effectsReviews & ratingsFDA package insert
More about PrometriumSide effectsReviews & ratingsFDA package insert
More about ProveraSide effectsReviews & ratingsFDA package insert