Prograf

(tacrolimus)

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Prevents rejection of a transplanted organ.

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Our bottom line

Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.

Quick facts about Prograf
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tacrolimus)
Prices and discounts
Lowest price for 90 1mg tablets
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$451.06

Upsides

  • Prevents your body from rejecting a transplanted organ.
  • Available as an extended-release pill, so it can be taken just once daily.
  • Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.

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What to expect from Prograf, on one page

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Downsides

  • Regular blood tests are required for monitoring while on Prograf (tacrolimus).
  • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
  • Increases your risk of infection and certain cancers.

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What to expect from Prograf, on one page

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Prices and discounts
Lowest price for 90 1mg tablets
Determining your location...
$451.06
How it works

Prograf (tacrolimus) is an immunosuppresant that lowers the activity of your immune system, so it doesn't attack the transplanted organ.

Quick facts about Prograf
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tacrolimus)

Used for

  • Prevention of heart transplant rejection
  • Prevention of liver transplant rejection
  • Prevention of kidney transplant rejection

Dosage forms

  • Pill
  • Extended release
  • Injection
Tried Prograf? Write a review!

What to expect when you take Prograf (tacrolimus) for Transplant rejection prevention

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Side effect rates for Prograf (tacrolimus)

From 157 clinical trials of Prograf when taken for heart transplant (taken with azathioprine and corticosteroids)
  • High blood pressure
  • Kidney Function Abnormal
  • Anemia
  • Low white blood cells
  • Viral infection
  • Diabetes Mellitus
  • Infection
  • High blood sugar
  • High cholesterol
  • Bronchitis

Risks and Warnings for Prograf (tacrolimus)

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    • Higher risk if:
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system

    Prograf (tacrolimus) works by lowering your immune response, so it increases your risk of bacterial, fungal, or viral infections.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Prograf (tacrolimus)

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Kidneys and liver
  • Prograf (tacrolimus) can cause kidney damage, especially in patients with poor kidney function, or who are taking other drugs that can damage the kidneys. Your doctor will order blood tests to check your kidney function and Prograf (tacrolimus) levels, and will change your dose if needed.
  • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.