Prescription onlyLower-cost generic availableClass: Transplant

Prograf Alternatives

(tacrolimus)

Prescription onlyLower-cost generic availableClass: Transplant
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Compare Prograf (tacrolimus) to alternatives

These medications are comparable to Prograf (tacrolimus) or used for similar purposes.

Prograf
(tacrolimus)

Cellcept
(mycophenolate mofetil)

Sandimmune
(cyclosporine)

Rapamune
(sirolimus)

Afinitor
(everolimus)

Prevents rejection of a transplanted organ. Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.Prevents organ transplant rejection. Cellcept (Mycophenolate Mofetil) is a good medication that prevents rejection of an organ transplant, but it can cause annoying stomach problems like diarrhea.Coming soon.Coming soon.Coming soon.
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Reviews & ratings
Filter group. All currently selected
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prograf (tacrolimus)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Cellcept (mycophenolate mofetil)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Sandimmune (cyclosporine)?
Worth itNot sureNot worth it

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Have you used Rapamune (sirolimus)?
Worth itNot sureNot worth it

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Have you used Afinitor (everolimus)?
Worth itNot sureNot worth it
Side effects
PrografCellceptSandimmuneRapamuneAfinitor
  • Diarrhea 72%
  • Headache 64%
  • Sleep difficulty 64%
  • Pain 63%
  • Abdominal pain 59%
  • Tremor 56%
  • Lack of energy 52%
  • Fever 48%
  • Low blood magnesium 48%
  • High blood sugar 47%
More Prograf side effects »
  • Urinary tract infection 37%
  • Pain 33%
  • High blood pressure 32%
  • Diarrhea 31%
  • Leg or ankle swelling 28%
  • Low red blood cells 26%
  • Abdominal pain 25%
  • Constipation 23%
  • Low white blood cells 23%
  • Infection 22%
More Cellcept side effects »

We haven’t found good data for Sandimmune side effects.

FDA side effect reports for Sandimmune »

We haven’t found good data for Rapamune side effects.

FDA side effect reports for Rapamune »

We haven’t found good data for Afinitor side effects.

FDA side effect reports for Afinitor »
How it works
PrografCellceptSandimmuneRapamuneAfinitor
Prograf (tacrolimus) is an immunosuppresant that lowers the activity of your immune system, so it doesn't attack the transplanted organ.Cellcept (Mycophenolate Mofetil) is an immunosuppresant that lowers the activity of your immune system, so it doesn't attack the transplanted organ.Coming soon.Coming soon.Coming soon.
Type of medication
PrografCellceptSandimmuneRapamuneAfinitor
Prescription onlyPrescription only
Available as
PrografCellceptSandimmuneRapamuneAfinitor
  • Pill
  • Extended release
  • Injection
  • Pill
  • Oral suspension
  • Pill
  • Liquid
  • Pill
  • Liquid
  • Pill
Used for
PrografCellceptSandimmuneRapamuneAfinitor
  • Prevention Of Heart Transplant Rejection
  • Cardiac Transplant Rejection Prophylaxis Liver Transplant Rejection Prophylaxis Plaque Psoriasis Severe
  • Renal Transplant Rejection
  • Angiomyolipoma Of Kidney Tuberous Sclerosis Syndrome
Risk factors for serious side effects
PrografCellceptSandimmuneRapamuneAfinitor
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
  • Taking Prograf (tacrolimus) for a long time
  • History of heart problems
Detailed Prograf (tacrolimus) risks & warnings »
  • Women of childbearing age
  • Taking other immunosuppressant drugs
  • Age 60 or older
  • Weak immune system
Detailed Cellcept (mycophenolate mofetil) risks & warnings »
    Coming soon.
      Coming soon.
        Coming soon.
        Pregnancy

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        Kidneys and liver
        PrografCellceptSandimmuneRapamuneAfinitor
        • Prograf (tacrolimus) can cause kidney damage, especially in patients with poor kidney function, or who are taking other drugs that can damage the kidneys. Your doctor will order blood tests to check your kidney function and Prograf (tacrolimus) levels, and will change your dose if needed.
        • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
        • It's a first-choice medication for preventing organ rejection since it doesn't hurt the kidneys or liver like other medications in its class.
        No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
        Weight
        PrografCellceptSandimmuneRapamuneAfinitor
        No weight related info.
        • Cellcept (Mycophenolate Mofetil) can increase your risk of serious or life-threatening bacterial, fungal, and viral infections. In some cases, infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). If you develop symptoms of fever, chills, muscle aches, or you notice dark urine, appetite/weight loss, vomiting, or a skin rash, tell your doctor and get medical care right away.
        No weight related info.No weight related info.No weight related info.
        Upsides and benefits
        PrografCellceptSandimmuneRapamuneAfinitor
        • Prevents your body from rejecting a transplanted organ.
        • Available as an extended-release pill, so it can be taken just once daily.
        • Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.
        • It's a first-choice medication for preventing organ rejection since it doesn't hurt the kidneys or liver like other medications in its class.
        • Can often be used by itself to prevent rejection without using more complicated medications like steroids or Tacrolimus.
        • However, survival rates are the highest and rejection is the lowest when Cellcept (Mycophenolate Mofetil) is used with other medications to prevent transplant rejection.
        Coming soonComing soonComing soon
        Downsides and risks
        PrografCellceptSandimmuneRapamuneAfinitor
        • Regular blood tests are required for monitoring while on Prograf (tacrolimus).
        • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
        • Increases your risk of infection and certain cancers.
        • Regular blood tests are needed, especially in the beginning, to make sure Cellcept (Mycophenolate Mofetil) isn't affecting your body in a bad way.
        • Diarrhea is the main reason why people stop taking Cellcept (Mycophenolate Mofetil).
        • If you're interested in becoming pregnant, you need to switch to a different medication since Cellcept (Mycophenolate Mofetil) can cause serious birth defects.
        • You may need to take another medicine to control your blood pressure, blood sugar, or cholesterol while on this.
        • Since it's an immunosuppressant, it can increase your risk of infections and certain cancers.
        Coming soonComing soonComing soon
        Tips from our pharmacists for people taking the medication
        PrografCellceptSandimmuneRapamuneAfinitor
        • Take your anti-rejection medicine consistently and at the same time each day.
        • It is important to check with your doctor before starting any other medicines, vitamins, or supplements to make sure it doesn't interfere with how your anti-rejection medicines work.
        • You will be more likely to catch an infection so practice good hand hygiene and avoid close contact with people who are sick. Also, wear gloves when you garden, keep any wounds clean and covered, and avoid sharing towels.
        • Can make you burn easily so wear protective clothing and sunblock if you have to be out in the sun.
        • Avoid grapefruit or grapefruit juice while on Prograf (tacrolimus).
        • You will need to get blood tests done regularly to make sure the drug is working properly.
        • Take Cellcept (Mycophenolate Mofetil) on an empty stomach, at least 1 hour before or 2 hours after a meal.
        • Don't be out in the sun for too long since you're more likely to get sunburned and increase the risk of skin cancer. Wear protective clothing and sunblock if you have to be out.
        • Cellcept (Mycophenolate Mofetil) can hurt or kill a fetus during pregnancy. Females of childbearing age must use two forms of birth control 4 weeks before, during, and 6 weeks after treatment.
        • Can cause stomach upset, headache, trouble sleeping, or affect your blood pressure, blood sugar, and cholesterol control.
        • Let your doctor know about any unusual bleeding, low energy, weakness, or flu-like symptoms.
        Coming soonComing soonComing soon
        Learn more
        More about PrografSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Prograf (tacrolimus)?
        Worth itNot sureNot worth it
        More about CellceptSide effectsReviews & ratingsFDA package insert
        Have you used Cellcept (mycophenolate mofetil)?
        Worth itNot sureNot worth it
        More about SandimmuneSide effectsFDA package insert
        Have you used Sandimmune (cyclosporine)?
        Worth itNot sureNot worth it
        More about RapamuneSide effectsReviews & ratingsFDA package insert
        Have you used Rapamune (sirolimus)?
        Worth itNot sureNot worth it
        More about AfinitorSide effectsFDA package insert
        Have you used Afinitor (everolimus)?
        Worth itNot sureNot worth it