Prescription onlyNo lower cost generic available



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Prevents bone loss.

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Prescription onlyNo lower cost generic available

Our bottom line

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.


  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.


  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.

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What to expect when you take Prolia (Denosumab)

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Tips from our pharmacists
  • Remember to get your shot every 6 months. Write it down on your calendar.
  • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
  • Can cause skin irritation, joint pain, limb pain, and back pain.
  • Let your doctor know if you start getting more infections.
  • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
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Side effects for Prolia (Denosumab)

From clinical trials of Prolia / Osteoporosis in postmenopausal women (60 mg)  ( 7762)

  • Back painBack pain35% for Prolia vs.35% for placebo
  • Pain in extremityPain in extremity12% for Prolia vs.11% for placebo
  • Musculoskeletal painMusculoskeletal pain8% for Prolia vs.8% for placebo
  • HypercholesterolemiaHypercholesterolemia7% for Prolia vs.6% for placebo
  • Bladder infectionBladder infection6% for Prolia vs.6% for placebo
  • Ankle and leg swellingAnkle and leg swelling5% for Prolia vs.4% for placebo
  • Ear, nose, or throat infectionEar, nose, or throat infection5% for Prolia vs.4% for placebo
  • SciaticaSciatica5% for Prolia vs.4% for placebo
  • VertigoVertigo5% for Prolia vs.5% for placebo
  • Lung infectionLung infection4% for Prolia vs.4% for placebo

Risks and Warnings for Prolia (Denosumab)

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    • Higher risk if:
    • Taking steroids

    Some people who take Prolia (Denosumab) have had unusual thigh fractures. However, it’s unclear if Prolia (Denosumab) causes these fractures. Report any unusual hip, thigh, or groin pain to your doctor.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Prolia (Denosumab)

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The FDA category for this medication is X. It is advised that you: Unsafe