4.9/ 7 average rating with 15 reviewsforProlia

Prolia
Alternatives

(Denosumab)

Prolia (Denosumab)

Prescription only

Fosamax (alendronate)

Prescription only
1 of 6 alternatives
Prevents bone loss.

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

Prevents bone loss.

Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.

Upsides
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
  • First choice to treat osteoporosis
  • Lowers your risk of fractures due to osteoporosis.
  • Available generic.
  • Available as daily, weekly, or twice weekly dosing.
  • Comes as a regular tablet, an oral solution, or effervescent tablet.
Downsides
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
  • Can harm your esophagus if you don't remain upright for 30 minutes after taking it.
  • Not recommended for people who can't sit or stand upright for at least 30 minutes.
  • Can increase the risk of atypical fractures.
  • Can cause bad heartburn or stomach problems.
Used for
Dosage forms
  • Injection
  • Pill
  • Effervescent tablet
  • Liquid
Price
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$2204.82
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$4
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Reviews
15 
33%
think this treatment is worth it
40%
think this treatment works well
27%
think this treatment is a hassle

Have you used Prolia (Denosumab)?

Leave a review
169 
43%
think this treatment is worth it
30%
think this treatment works well
19%
think this treatment is a hassle

Have you used Fosamax (alendronate)?

Leave a review
Side effects
10possible side effects
  • Back pain
    35%
  • Pain in extremity
    12%
  • Musculoskeletal pain
    8%
  • Hypercholesterolemia
    7%
  • Cystitis
    6%
  • Vertigo
    5%
  • Edema peripheral
    5%
  • Upper respiratory tract infection
    5%
  • Sciatica
    5%
  • Pneumonia
    4%
See more detailed side effects
1possible side effects
  • Abdominal pain
    2%
See more detailed side effects
Risks and warnings
  • Leg bone fractures

    Taking steroids

  • Low calcium blood levels

    Kidney problems

    ...and 3 more risk factors

  • Infection

    Weak immune system

    ...and 1 more risk factors

  • Problems in the jaw bone

    Oral or dental surgery

    ...and 3 more risk factors

See more detailed risks and warnings
  • Irritation and ulcers to the stomach and esophagus

    Taking anti-inflammatory medicines like ibuprofen, and naproxen

    ...and 3 more risk factors

  • Problems in the jaw bone

    Oral or dental surgery

    ...and 3 more risk factors

See more detailed risks and warnings