Prescription onlyLower-cost generic available

Prometrium

(Progesterone)

  • Pill
  • Injection
  • Amenorrhea
  • Prevention of uterine cancer in women taking estrogen
  • Abnormal uterine bleeding
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Taken for irregular bleeding or paired with estrogen replacements for menopause.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.

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  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.

Save on your next Prometrium (Progesterone) prescription

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Side effects for Prometrium (Progesterone)

From clinical trials of Prometrium / Amenorrhea (400 mg) ( 49)

  • DizzinessDizziness24% for Prometrium vs.4% for placebo
  • Abdominal pain (cramping)Abdominal pain (cramping)20% for Prometrium vs.13% for placebo
  • HeadacheHeadache16% for Prometrium vs.8% for placebo
  • Breast painBreast pain16% for Prometrium vs.8% for placebo
  • Musculoskeletal painMusculoskeletal pain12% for Prometrium vs.4% for placebo
  • Infection viralInfection viral12% for Prometrium vs.0% for placebo
  • NauseaNausea8% for Prometrium vs.0% for placebo
  • Back painBack pain8% for Prometrium vs.8% for placebo
  • FatigueFatigue8% for Prometrium vs.4% for placebo
  • IrritabilityIrritability8% for Prometrium vs.4% for placebo

What to expect when you take Prometrium (Progesterone)

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Tips from our pharmacists
  • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it the same time every day.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).

Risks and Warnings for Prometrium (Progesterone)

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    • Higher risk if:
    • Personal or family history of breast cancer

    It is not completely clear if progestin, like as Prometrium (Progesterone), increases your risk of breast cancer. There may be a higher risk if you have a history of breast cancer, so make sure to get routine breast exams.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Prometrium (Progesterone)

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The FDA category for this medication is B. It is advised that you: Probably safe
Pregnancy
Sleep
  • Tips from our pharmacists
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
Weight gain or loss
  • Tips from our pharmacists
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.