Prescription onlyLower-cost generic available



Prescription onlyLower-cost generic available
  • Pill
  • Injection
  • Amenorrhea
  • Prevention of uterine cancer in women taking estrogen
  • Abnormal uterine bleeding
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Taken for irregular bleeding or paired with estrogen replacements for menopause.

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Our bottom line

Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.

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  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
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  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
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Side effect rates for Prometrium (Progesterone)

49 From clinical trials of Prometrium / Amenorrhea (400 mg)
  • Dizziness
  • Abdominal pain (cramping)
  • Headache
  • Breast pain
  • Musculoskeletal pain
  • Infection viral
  • Coughing
  • Back pain
  • Fatigue
  • Irritability

Risks and Warnings for Prometrium (Progesterone)

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    • Higher risk if:
    • Personal or family history of breast cancer

    It is not completely clear if progestin, like as Prometrium (Progesterone), increases your risk of breast cancer. There may be a higher risk if you have a history of breast cancer, so make sure to get routine breast exams.

Common concerns from people taking Prometrium (Progesterone)

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  • Relives pain from endometriosis.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Prometrium (Progesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.