Prescription onlyLower-cost generic availableClass: Women's health

Prometrium Alternatives

(progesterone)

Prescription onlyLower-cost generic availableClass: Women's health
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Compare Prometrium (progesterone) to alternatives

These medications are comparable to Prometrium (progesterone) or used for similar purposes.

Prometrium
(progesterone)

Aygestin
(norethindrone)

Provera
(medroxyprogesterone)

Taken for irregular bleeding or paired with estrogen replacements for menopause. Prometrium (Progesterone) regulates menstrual cycles, treats heavy bleeding, and prevents thickening of the uterus.Regulates your menstrual cycle and treats irregular bleeding. Aygestin (norethindrone) regulates the menstrual cycle and treats heavy or irregular vaginal bleeding. It's easy to take and isn't expensive.Regulates your menstrual cycle and supplements estrogen treatments for menopause. Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.58Prometrium
Reviews for Prometrium
61%
of people (All ages) say Prometrium is worth it
41%
say it works well
17%
say it's a big hassle
Have you used Prometrium (progesterone)?
Worth itNot sureNot worth it
Reviews for Aygestin
40%
+21% better vs. Prometrium
23%
+18% better vs. Prometrium
23%
+6% better vs. Prometrium
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it

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Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it
Side effects
PrometriumAygestinProvera
  • Headache 4%
  • Breast tenderness 21%
  • Low mood disorder 7%
  • Dizziness 6%
  • Abdominal bloating 7%
  • Urinary problems 2%
  • Vaginal discharge 7%
More Prometrium side effects »

The Aygestin FDA package insert doesn’t have numbers about how common side effects are.

More about Aygestin side effects »

We haven’t found good data for Provera side effects.

FDA side effect reports for Provera »
How it works
PrometriumAygestinProvera
Prometrium (Progesterone) contains progesterone, a hormone that regulates the menstrual cycle and protects the uterus from the negative effects of estrogen when used for postmenopausal treatment.Aygestin (norethindrone) contains norethindrone, a synthetic progesterone hormone. It regulates your period, treats irregular vaginal bleeding, and eases the pain of endometriosis (a condition where tissue that lines your uterus is found in other parts of the body).Provera (Medroxyprogesterone) contains medroxyprogesterone, a progesterone hormone that works to balance hormone changes in the body. In premenopausal women, it prevents thickening of the uterus lining and regulates your menstrual cycle. It's also added to hormone therapy to protect the uterus from the harmful effects of estrogen.
Type of medication
PrometriumAygestinProvera
Prescription onlyPrescription onlyPrescription only
Available as
PrometriumAygestinProvera
  • Pill
  • Injection
  • Pill
  • Pill
Used for
PrometriumAygestinProvera
  • Amenorrhea
  • Pain Caused By Endometriosis
  • Amenorrhea
Risk factors for serious side effects
PrometriumAygestinProvera
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Prometrium (progesterone) risks & warnings »
  • Personal or family history of blood clots
  • Smoking
  • Obesity
  • Systemic lupus erythematosus (SLE)
  • History of depression
Detailed Aygestin (norethindrone) risks & warnings »
  • Personal or family history of breast cancer
  • Family history of ovarian cancer
  • Personal or family history of blood clots
  • Smoking
  • Obesity
Detailed Provera (medroxyprogesterone) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Kidneys and liver
PrometriumAygestinProvera
No kidneys and liver related info.
  • Aygestin (norethindrone) is broken down by the liver, so if the liver is damaged, the drug can build up in your body. Tell your doctor if you've had liver disease or damage. Your doctor will have to change Aygestin (norethindrone) to a different medicine.
No kidneys and liver related info.
Pain
PrometriumAygestinProvera
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Relives pain from endometriosis.
  • Aygestin (norethindrone) can raise your risk of blood clots, which can be very dangerous. You're more likely to have them if you smoke tobacco, are obese, or if you or your family have ever had blood clots. Get medical care right away if you have pain in your legs or arms, bad headaches, trouble breathing, or sudden changes in your speech or vision.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
No pain related info.
Weight
PrometriumAygestinProvera
  • Prometrium (Progesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Can make you gain weight.
  • Provera (Medroxyprogesterone) contains progestin. It could cause a higher risk of ovarian cancer, especially if you have a family history of it. Your doctor can help you weigh the risks versus the benefits of this medication.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
Upsides and benefits
PrometriumAygestinProvera
  • Helps to regulate your menstrual cycle.
  • Relives pain from endometriosis.
  • Lowers the risk of uterine cancer when used with estrogen in women with an intact uterus.
  • Available as a capsule or an injection, so you can choose what works best for you.
  • Helps to regulate your period.
  • Decreases bleeding from hormone imbalance.
  • Available as a generic medication, so it costs less.
  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
Downsides and risks
PrometriumAygestinProvera
  • Prometrium (Progesterone) capsules contain peanut oil, so you can't take it if you're allergic to peanuts.
  • Prometrium (Progesterone) can cause serious birth defects in babies, so you can't take Prometrium (Progesterone) if you’re pregnant or breast-feeding.
  • Increases your risk of blood clots.
  • Can make you gain weight.
  • Higher risk of blood clots.
  • Not for people who are post-menopausal, pregnant, or breast-feeding.
  • Can cause a lot of side effects.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.
Tips from our pharmacists for people taking the medication
PrometriumAygestinProvera
  • The dose of Prometrium (Progesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it the same time every day.
  • Prometrium (Progesterone) capsules can make you feel tired or dizzy, so take it just before you go to sleep every night.
  • If you have trouble swallowing the capsule, take it with a full glass of water while standing up.
  • Can cause cramps, bloating, trouble sleeping, acne, weight gain, facial skin discoloration, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • Get immediate medical help if you have sudden vision changes or one-sided weakness (signs of stroke) or chest pain and trouble breathing (signs of a pulmonary embolism).
  • The dose of Aygestin (norethindrone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • It's important to take it at the same time every day.
  • Talk to your doctor every few months about using the lowest possible dose of Aygestin (norethindrone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • If you're taking Aygestin (norethindrone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Aygestin (norethindrone).
  • Aygestin (norethindrone) can cause cramps, bloating, trouble sleeping, acne, weight gain, or irregular periods.
  • Tell your doctor about any severe stomach pain or yellowing of your eyes or skin.
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).
Learn more
More about PrometriumSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prometrium (progesterone)?
Worth itNot sureNot worth it
More about AygestinSide effectsReviews & ratingsFDA package insert
Have you used Aygestin (norethindrone)?
Worth itNot sureNot worth it
More about ProveraSide effectsReviews & ratingsFDA package insert
Have you used Provera (medroxyprogesterone)?
Worth itNot sureNot worth it