Prescription onlyNo lower cost generic available



  • Cream, gel, or ointment
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Treats eczema.

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Prescription onlyNo lower cost generic available

Our bottom line

Astagraf (Tacrolimus) is effective at treating eczema if other options haven’t helped, but its long-term effects aren’t well known. Your doctor will decide how long you should use it for.


  • Astagraf (Tacrolimus) is effective at treating eczema, if other options haven’t worked or shouldn’t be used.
  • Many people see an improvement in their skin in as early as one week.
  • Doesn’t have alcohol in it, so it won’t dry your skin out.


  • Not available in a generic form.
  • Can’t be used in children under ages 2 years old.
  • Can’t be used if your immune system is weak (for example, if you have cancer or are taking steroids for a long time).
  • Not recommended to be used for a very long period of time. If you have to keep using Astagraf (Tacrolimus), your doctor will probably have you take breaks in-between.

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What to expect when you take Astagraf (Tacrolimus)

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Tips from our pharmacists
  • Apply only to the areas where you have eczema.
  • Use only as long as your doctor tells you to. Don’t use for a longer period of time.
  • May cause some burning, stinging, or itching at first, but this usually goes away as your skin gets used to the medicine.
  • When you apply Astagraf (Tacrolimus) on your skin, don’t cover that area with bandages or dressings.
  • Don’t apply to infected areas of your skin. Let your doctor know if you have an infection.
  • Don’t use sun lamps or tanning beds. Try to limit your time outside in the sun, but if you need to go out, use sun protection.
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Side effects for Astagraf (Tacrolimus)

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These are side effects of Astagraf (Tacrolimus) reported to the FDA by people taking it, and by doctors and pharmacists.

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Risks and Warnings for Astagraf (Tacrolimus)

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  • Cancers of the skin and lymphatic system have been reported in patients using Astagraf (Tacrolimus). However, this is very rare, and it hasn’t been established that Astagraf (Tacrolimus) causes these malignancies. You should apply Astagraf (Tacrolimus) only to the affected areas of your skin, and use for short periods only. Your doctor will decide how long you should be using Astagraf (Tacrolimus).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Astagraf (Tacrolimus)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
  • Upsides and downsides from our pharmacists
  • Doesn’t have alcohol in it, so it won’t dry your skin out.