Prescription onlyLower-cost generic available



  • Pill
  • Amenorrhea
  • Abnormal uterine bleeding
  • Prevention of uterine cancer in women taking estrogen
  • Endometriosis
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Regulates your menstrual cycle and supplements estrogen treatments for menopause.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Provera (Medroxyprogesterone) works well to regulate your menstrual cycle and stop irregular bleeding. It also protects the uterus from estrogen's harmful effects.

  • Provera (Medroxyprogesterone) can be used to treat multiple hormone problems in women.
  • After menopause, taking estrogen raises your risk of uterine cancer. However, taking progesterone, like in Provera (Medroxyprogesterone), along with estrogen gives you the positive effects of estrogen, but also prevents it from damaging your uterus.
  • Women taking an estrogen/progestin combination medications have a lower risk of uterine cancer.
  • You can't take Provera (Medroxyprogesterone) if you've had a hysterectomy (your uterus removed). You also can't take it if you're pregnant or breastfeeding, have unusual vaginal bleeding, or have a history of blood clots, certain kinds of cancer, stroke, heart attack, liver problems, or bleeding problems.

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Side effects for Provera (Medroxyprogesterone)

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These are side effects of Provera (Medroxyprogesterone) reported to the FDA by people taking it, and by doctors and pharmacists.

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What to expect when you start Provera (Medroxyprogesterone)

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Tips from our pharmacists
  • The dose of Provera (Medroxyprogesterone) will be different depending on what you’re using it for, so take it exactly the way your doctor tells you.
  • Talk to your doctor every few months about using the lowest possible dose of Provera (Medroxyprogesterone). Since there can be a lot of long-term side effects, take it only as long as you need it.
  • Can cause headache, weight gain, breast tenderness, or changes in mood.
  • If you're taking Provera (Medroxyprogesterone) to regulate your period, you'll get withdrawal bleeding 3 to 7 days after stopping Provera (Medroxyprogesterone).

Risks and Warnings for Provera (Medroxyprogesterone)

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    • Higher risk if:
    • Personal or family history of breast cancer

    It is not completely clear if progestin, like as Provera (Medroxyprogesterone), increases your risk of breast cancer. There may be a higher risk if you have a history of breast cancer, so make sure to get routine breast exams.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Provera (Medroxyprogesterone)

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The FDA category for this medication is X. It is advised that you: Unsafe
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  • Tips from our pharmacists
  • Can cause headache, weight gain, breast tenderness, or changes in mood.