Prescription onlyLower-cost generic available

Provigil

(Modafinil)

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Improves alertness.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.

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Works well?Does it work?
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  • It's a non-amphetamine medicine that helps improve alertness.
  • Available in a generic version.
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
  • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
  • Interacts with many other medications.
  • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
  • Not a good choice if you have liver or kidney problems.

Save on your next Provigil (Modafinil) prescription

Be sure you’re getting the lowest price for your medication, even if you have insurance.

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Side effects for Provigil (Modafinil)

From clinical trials of Provigil / Excessive sleepiness ( 1501)

  • HeadacheHeadache34% for Provigil vs.23% for placebo
  • NauseaNausea11% for Provigil vs.3% for placebo
  • Any side effectAny side effect8% for Provigil vs.3% for placebo
  • Inflammation inside the noseInflammation inside the nose7% for Provigil vs.6% for placebo
  • NervousnessNervousness7% for Provigil vs.3% for placebo
  • Back painBack pain6% for Provigil vs.5% for placebo
  • DiarrheaDiarrhea6% for Provigil vs.5% for placebo
  • AnxietyAnxiety5% for Provigil vs.1% for placebo
  • IndigestionIndigestion5% for Provigil vs.4% for placebo
  • DizzinessDizziness5% for Provigil vs.4% for placebo

What to expect when you take Provigil (Modafinil) for Narcolepsy

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Tips from our pharmacists
  • Take Provigil (Modafinil) about an hour before you need to be fully alert.
  • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
  • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
  • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
  • Tell your doctor right away if you break out in a rash.
  • Don't drink alcohol with Provigil (Modafinil).

Risks and Warnings for Provigil (Modafinil)

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    • Higher risk if:
    • Taking with alcohol
    • Taking other medicines that make you less alert

    Provigil (Modafinil) lowers your ability to focus, think, and react. Be careful. Avoid activities that require you to be alert, such as driving a car or operating machinery, until you know how this medication affects you.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Provigil (Modafinil)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Alcohol
  • Tips from our pharmacists
  • Don't drink alcohol with Provigil (Modafinil).
Kidneys & liver
  • Upsides and downsides from our pharmacists
  • Not a good choice if you have liver or kidney problems.
  • Risks from our pharmacists
  • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
Sleep
  • Upsides and downsides from our pharmacists
  • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
  • Doesn't negatively affect daytime sleep.
  • Around $20/pill without insurance. Can cause headaches while getting used to. Take it in the morning or risk being too alert to sleep. Not speedy like amphetamines
    Age: 33
    Gender: Woman
    Taken for: Excessive daytime sleepiness
  • I have RLS, and helped me tremendously with sleepiness in the daytime. As long as I did not take after noon, had no problems sleeping. It is expensive and my inurance company just stopped paying for it. Just started ritalin today. Wish lu
    Age: 59
    Gender: Woman
    Taken for: Excessive daytime sleepiness