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Provigil Alternatives

(Modafinil)

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Compare Provigil (Modafinil) to alternatives

These medications are comparable to Provigil (Modafinil) or used for similar purposes.

Provigil
(Modafinil)

Nuvigil
(Armodafinil)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Makes you feel awake. Nuvigil (Armodafinil) is effective in improving alertness, but it can interact with other medications and shouldn't be used long-term.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.565217391304348Provigil
Reviews for Provigil (Modafinil)
78%
of people say Provigil (Modafinil) is worth it
70%
say it works well
4%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
ProvigilNuvigil
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Nervousness 4%
  • Sleep difficulty 4%
  • Anxiety 4%
  • Loss of appetite 3%
  • Dry mouth 2%
  • Sore throat 2%
  • Chest pain 2%
More Provigil side effects »
  • Headache 14%
  • Nausea 6%
  • Sleep difficulty 5%
  • Adverse events 3%
  • Dizziness 3%
  • Anxiety 3%
  • Diarrhea 2%
  • Constipation 1%
  • Thirst 1%
  • Heart pounding or racing sensation 1%
More Nuvigil side effects »
How it works
ProvigilNuvigil
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Nuvigil (Armodafinil) is a stimulant that helps you feel awake by affecting neurotransmitters in the brain.
Type of medication
ProvigilNuvigil
StimulantPrescription only
StimulantPrescription only
Available as
ProvigilNuvigil
  • Pill
  • Pill
Used for (click to learn more)
ProvigilNuvigil
Risk factors for serious side effects
ProvigilNuvigil
  • Taking with alcohol
  • Taking other medicines that make you less alert
      • Current kidney problems
      • Current liver problems
      • History of heart problems
      • History of psychiatric disorder
      • History of bipolar disorder
      Detailed Provigil (Modafinil) risks & warnings »
      Coming soon.
      Pregnancy category
      ProvigilNuvigil
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      Alcohol
      • Don't drink alcohol with Provigil (Modafinil).
      • Don't drink alcohol with Nuvigil (Armodafinil).
      Food
      No specific food-related info.No specific food-related info.
      Kidneys and liver
      • Not a good choice if you have liver or kidney problems.
      • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
      • Nuvigil (Armodafinil) is processed in the liver so it's not a good choice if you have liver, or even kidney, problems.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
      • Doesn't negatively affect daytime sleep.
      • Effective in treating excess sleepiness in shift work sleep disorder (SWSD).
      • Doesn't negatively affect daytime sleep.
      • If using for shift work sleep disorder (SWSD), take Nuvigil (Armodafinil) about an hour before the start of your shift.
      Weight
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      ProvigilNuvigil
      • It's a non-amphetamine medicine that helps improve alertness.
      • Available in a generic version.
      • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
      • Doesn't negatively affect daytime sleep.
      • Effective in treating excess sleepiness in shift work sleep disorder (SWSD).
      • It's a non-amphetamine medication that helps improve alertness.
      • Doesn't negatively affect daytime sleep.
      Downsides and risks
      ProvigilNuvigil
      • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
      • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
      • Not a good choice if you have liver or kidney problems.
      • Interacts with many other medications.
      • Nuvigil (Armodafinil) can be habit-forming, so it's typically not used for long-term treatment.
      • Reduces the effectiveness of birth control pills. You need to use an additional contraceptive method while taking Nuvigil (Armodafinil).
      • Nuvigil (Armodafinil) is processed in the liver so it's not a good choice if you have liver, or even kidney, problems.
      • Not available as a generic.
      • Interacts with many other medications.
      Tips from our pharmacists for people taking the medication
      ProvigilNuvigil
      • Take Provigil (Modafinil) about an hour before you need to be fully alert.
      • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
      • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
      • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
      • Don't drink alcohol with Provigil (Modafinil).
      • Tell your doctor right away if you break out in a rash.
      • If using for shift work sleep disorder (SWSD), take Nuvigil (Armodafinil) about an hour before the start of your shift.
      • Taking caffeine with Nuvigil (Armodafinil) can make you feel nervous, shaky, and will raise your heartbeat.
      • If you've been taking Nuvigil (Armodafinil) for a while and decide to stop it, you'll experience withdrawal symptoms if you stop it too fast.
      • Don't drink alcohol with Nuvigil (Armodafinil).
      • Tell your doctor right away if you break out in a rash.
      Learn more
      More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
      More about NuvigilSide effectsReviews & ratingsFDA package insert