Prescription onlyLower-cost generic availableClass: Mental health

Provigil Alternatives

(Modafinil)

Prescription onlyLower-cost generic availableClass: Mental health
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Compare Provigil (Modafinil) to alternatives

These medications are comparable to Provigil (Modafinil) or used for similar purposes.

Provigil
(Modafinil)

Nuvigil
(Armodafinil)

Improves alertness. Provigil (Modafinil) is effective in improving alertness, but it can interact with other medicines and shouldn't be used long-term.Makes you feel awake. Nuvigil (Armodafinil) is effective in improving alertness, but it can interact with other medications and shouldn't be used long-term.
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Reviews & ratings
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Have you used Provigil (Modafinil)?
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Have you used Nuvigil (Armodafinil)?
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Side effects
ProvigilNuvigil
  • Headache 11%
  • Nausea 8%
  • Any side effect 5%
  • Inflammation inside the nose 1%
  • Nervousness 4%
  • Back pain 1%
  • Diarrhea 1%
  • Dizziness 1%
  • Sleep difficulty 4%
  • Indigestion 1%
More Provigil side effects »
  • Headache 8%
  • Adverse events 3%
  • Nausea 4%
  • Dizziness 3%
  • Sleep difficulty 4%
  • Anxiety 3%
  • Dry mouth 3%
  • Diarrhea 2%
  • Indigestion 2%
  • Thirst 1%
More Nuvigil side effects »
How it works
ProvigilNuvigil
Provigil (Modafinil) is a stimulant that helps you feel awake. Researchers don't know exactly how Provigil (Modafinil) works, but it probably affects chemicals (neurotransmitters) in the brain.Nuvigil (Armodafinil) is a stimulant that helps you feel awake by affecting neurotransmitters in the brain.
Type of medication
ProvigilNuvigil
Prescription only
Prescription only
Available as
ProvigilNuvigil
  • Pill
  • Pill
Used for
ProvigilNuvigil
Risk factors for serious side effects
ProvigilNuvigil
  • Taking with alcohol
  • Taking other medicines that make you less alert
    • Current kidney problems
    • Current liver problems
    • History of heart problems
    • History of psychiatric disorder
    • History of bipolar disorder
    Detailed Provigil (Modafinil) risks & warnings »
    • Taking with alcohol
    • Taking other medicines that make you less alert
      • Current kidney problems
      • Current liver problems
      • History of heart problems
      • History of psychiatric disorder
      • History of bipolar disorder
      Detailed Nuvigil (Armodafinil) risks & warnings »
      Pregnancy

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Interactions
      ProvigilNuvigil
      • Interacts with many other medications.
      • Interacts with many other medications.
      Alcohol
      ProvigilNuvigil
      • Don't drink alcohol with Provigil (Modafinil).
      • Don't drink alcohol with Nuvigil (Armodafinil).
      Kidneys and liver
      ProvigilNuvigil
      • Not a good choice if you have liver or kidney problems.
      • Provigil (Modafinil) is broken down by the kidney and liver. If you have kidney or liver problems, you may need to use a lower dose to prevent more side effects.
      • Nuvigil (Armodafinil) is processed in the liver so it's not a good choice if you have liver, or even kidney, problems.
      • Nuvigil (Armodafinil) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose, or other medication, to prevent increased risk of side effects.
      Upsides and benefits
      ProvigilNuvigil
      • It's a non-amphetamine medicine that helps improve alertness.
      • Available in a generic version.
      • Effective in reducing excessive sleepiness in Shift-work Sleep Disorder.
      • Doesn't negatively affect daytime sleep.
      • Effective in treating excess sleepiness in shift work sleep disorder (SWSD).
      • Doesn't negatively affect daytime sleep.
      • It's a non-amphetamine medication that helps improve alertness.
      Downsides and risks
      ProvigilNuvigil
      • Provigil (Modafinil) can be habit-forming, so it's typically not used for long-term treatment.
      • Interacts with many other medications.
      • Taking Provigil (Modafinil) will make hormonal birth control less effective. You should definitely use additional forms of non-hormonal contraception.
      • Not a good choice if you have liver or kidney problems.
      • Nuvigil (Armodafinil) can be habit-forming, so it's typically not used for long-term treatment.
      • Interacts with many other medications.
      • Reduces the effectiveness of birth control pills. You need to use an additional contraceptive method while taking Nuvigil (Armodafinil).
      • Nuvigil (Armodafinil) is processed in the liver so it's not a good choice if you have liver, or even kidney, problems.
      • Not available as a generic.
      Tips from our pharmacists for people taking the medication
      ProvigilNuvigil
      • Take Provigil (Modafinil) about an hour before you need to be fully alert.
      • Taking caffeine with Provigil (Modafinil) can cause you to feel nervous, shaky, and have a faster heartbeat. Try limiting your caffeine intake.
      • Until you know how Provigil (Modafinil) makes you feel, don't drive or perform any tasks that need you to be alert.
      • You can experience withdrawal symptoms if you suddenly stop taking Provigil (Modafinil). Talk to your doctor before making any changes.
      • Tell your doctor right away if you break out in a rash.
      • Don't drink alcohol with Provigil (Modafinil).
      • If using for shift work sleep disorder (SWSD), take Nuvigil (Armodafinil) about an hour before the start of your shift.
      • Taking caffeine with Nuvigil (Armodafinil) can make you feel nervous, shaky, and will raise your heartbeat.
      • If you've been taking Nuvigil (Armodafinil) for a while and decide to stop it, you'll experience withdrawal symptoms if you stop it too fast.
      • Tell your doctor right away if you break out in a rash.
      • Don't drink alcohol with Nuvigil (Armodafinil).
      Learn more
      More about ProvigilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Provigil (Modafinil)?
      Worth itNot sureNot worth it
      More about NuvigilSide effectsReviews & ratingsFDA package insert
      Have you used Nuvigil (Armodafinil)?
      Worth itNot sureNot worth it