Prescription onlyLower-cost generic available

Prozac

(Fluoxetine)

Prescription onlyLower-cost generic available
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Improves mood and helps you relax.

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Our bottom line

Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.

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Upsides

  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
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Downsides

  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.

What to expect when you take Prozac (Fluoxetine) for Depression

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Risks and Warnings for Prozac (Fluoxetine)

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    • Higher risk if:
    • Age 24 years or younger

    Prozac (Fluoxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Prozac (Fluoxetine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Prozac (Fluoxetine)

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Pregnancy
Interactions
  • It made me extremely depressed and interacted with my birth control. I had to stop taking my birth control to take it. I also kept arriving late to work.
Alcohol
  • Made me very sensitive to alcohol, could not drink while taking this med without causing a panic attack. Also made me get car sick all the time.
  • It worked well. Mixing with alcohol intensifies affects and can be dangerous.
  • Lowers libido. Suppresses desire to drink alcoholic beverages. Caused significant tinnitus..
Food
  • Take in the morning with food to avoid side effects.
  • It doesn't say to take with food but I highly encourage it. I also encourage drinking lots of fluids after taking it I find that it helps with the stomach butterflies that last a couple of weeks. Take it early in the morning if you want to go to sleep at a reasonable time and make sure your doctor knows if sleep IS a problem. Stick out the side effects, if they are only mildly uncomfortable it will get better and you will love watching it work even more once they've passed.
  • Take in morning with food for best results.
  • Take it at the same time every day with food otherwise you could get stomach ache or heart burn
Pain
  • Caused night sweats but increased energy and decreased chronic pain issues.
Sex
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • It causes a lot of dryness and low libido - can definitely tank your sex life.
  • Lowers libido. Suppresses desire to drink alcoholic beverages. Caused significant tinnitus..
  • It makes it REALLY hard to orgasm. Just FYI
Sleep
  • might make you sleepy
  • In order to combat the drowsiness, I recommend taking this medication before bed.
  • That it would make you sleepier.
Weight
  • It caused me to gain weight, which made my depression worse
  • Some weight gain
  • Too many continued side effects for me. They outweighed the effects of the drug