Prescription onlyLower-cost generic availableClass: Mental health



Prescription onlyLower-cost generic availableClass: Mental health
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Improves mood and helps you relax.

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Our bottom line

Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.

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  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
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1319 reviews


  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
How it works

Prozac (Fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.

What to expect when you take Prozac (fluoxetine) for Depression

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Side effect rates for Prozac (fluoxetine)

  • Decreased libido

Risks and Warnings for Prozac (fluoxetine)

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    • Higher risk if:
    • Age 24 years or younger

    Prozac (Fluoxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Prozac (Fluoxetine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Prozac (fluoxetine)

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  • Lowers libido. Suppresses desire to drink alcoholic beverages. Caused significant tinnitus..
  • It worked well. Mixing with alcohol intensifies affects and can be dangerous.
  • Made me very sensitive to alcohol, could not drink while taking this med without causing a panic attack. Also made me get car sick all the time.
  • Take in the morning with food to avoid side effects.
  • Take it with food or it'll make your appetite go away for hours.
  • Take it at the same time every day with food otherwise you could get stomach ache or heart burn
  • Take in morning with food for best results.
  • Caused night sweats but increased energy and decreased chronic pain issues.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Decreases libido, makes me sleepy
  • It makes it REALLY hard to orgasm. Just FYI
  • It causes a lot of dryness and low libido - can definitely tank your sex life.
  • Take at night. Prozac made me drowsy
  • Prozac made me sleepy, so I took it in the evening. Beware - not all generics are the same. Worked wonders! :-)
  • Can't sleep very well, killed my sex drive
  • It never made me gain weight but it killed my sex drive!
  • Can cause weight gain due to its use as a treatment for bulimia. The sexual side affects aren't completely limiting however keep in mind that while it may help those whom are over stimulated to calm down, it can cause extreme difficulty in maintaining an errection and interest, so your wife might get pissed.
  • Too many continued side effects for me. They outweighed the effects of the drug