Prescription onlyLower-cost generic available



Back to: Full Site NavigationSkip to: side effects sectionSkip to: What to expect sectionSkip to: Risks and warnings sectionSkip to: Tips from users and pharmacists

Prevents bone loss.

Skip Upsides & Downsides section. Skip to side effects section.
Prescription onlyLower-cost generic available

Our bottom line

Reclast (Zoledronate) is a first-choice treatment for osteoporosis and is available as a generic, but you have to see a doctor to get each dose.


  • Available in generic.
  • You only have to take this once a year.
What do people say?
36 reviews


  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.

Save on your next Reclast (Zoledronate) prescription

Get the lowest price for your medication, even if you have insurance.

  • (1) 100ml of 5mg/100ml solution bottle
  • Cost for (1) 100ml of 5mg/100ml solution bottle of Reclast (Zoledronate) at pharmacies

What to expect when you take Reclast (Zoledronate)

Skip what to expect section. Skip to Risks & Warnings section.
Tips from our pharmacists
  • Given as an intravenous infusion.
  • Eat normally and drink at least two glasses of liquid before your infusion.
  • Talk to your doctor if you develop swelling, pain, or a sore in your jaw.
  • Call your doctor if you develop pain in your hips, thighs or legs.
  • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
  • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
  • Drink plenty of liquids while you're on this medication.
Skip side effects sections. Skip to What to Expect and Pharmacists Tips section.

Side effects for Reclast (Zoledronate)

From clinical trials of Reclast / Osteoporosis (Men) (5 mg- once per year)  ( 301)

  • Muscle painMuscle pain20% for Reclast vs.7% for placebo
  • FatigueFatigue18% for Reclast vs.6% for placebo
  • Acute phase reactionAcute phase reaction17% for Reclast vs.0% for placebo
  • HeadacheHeadache15% for Reclast vs.6% for placebo
  • Musculoskeletal painMusculoskeletal pain12% for Reclast vs.11% for placebo
  • PainPain12% for Reclast vs.4% for placebo
  • ChillsChills10% for Reclast vs.3% for placebo
  • Influenza-like illnessInfluenza-like illness9% for Reclast vs.2% for placebo
  • Abdominal painAbdominal pain8% for Reclast vs.4% for placebo
  • Shortness of breathShortness of breath7% for Reclast vs.5% for placebo

Manufacturers don’t say how common these side effects are

  • Renal impairment

Risks and Warnings for Reclast (Zoledronate)

Skip Risks and Warnings section. Skip to Tips section.
  • People on Reclast (Zoledronate) have reported severe pain to the bones and muscles. However, this is very rare. Stop taking the medication and talk to your doctor if this happens to you.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Reclast (Zoledronate)

Final section. Do you want to return to drug navigation?
The FDA category for this medication is D. It is advised that you: Weigh risks vs. benefits