Prescription onlyLower-cost generic availableClass: Musculoskeletal

Reclast Alternatives

(zoledronate)

Prescription onlyLower-cost generic availableClass: Musculoskeletal
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Compare Reclast (zoledronate) to alternatives

These medications are comparable to Reclast (zoledronate) or used for similar purposes.

Reclast
(zoledronate)

Fosamax
(alendronate)

Actonel
(risedronate)

Boniva
(ibandronate)

Prolia
(denosumab)

Forteo
(teriparatide)

Evista
(raloxifene)

Miacalcin
(calcitonin)

Prevents bone loss. Reclast (zoledronate) is a good choice for osteoporosis if you aren't able to take bisphosphonates by mouth. It is available as a generic, but you have to see a doctor to get each dose.Prevents bone loss. Fosamax (alendronate) is a first-choice treatment for osteoporosis, but taking it can be a hassle.Prevents bone loss. Actonel (risedronate) is a first-choice treatment for osteoporosis and is available as a generic, but taking it can be a hassle.Prevents bone loss. Boniva (ibandronate) is a first-choice treatment for osteoporosis and is available as a generic, but how you have to take it can be a hassle. It's also only approved for women, not men.Prevents bone loss. Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.Prevents bone loss. Forteo (Teriparatide) is a good second-choice medication to treat bone loss, but it's only available as an injectable.Prevents bone loss and lowers your risk of breast cancer. Evista (Raloxifene) is effective at reducing bone loss and lowering the risk of breast cancer in postmenopausal women, but does carry the risk of blood clots.Treats high calcium levels and prevents bone loss. Miacalcin (calcitonin) can be used for osteoporosis, but it is not a first choice because there are more effective medications available.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.08Reclast
Reviews for Reclast
28%
of people (All ages) say Reclast is worth it
28%
say it works well
36%
say it's a big hassle
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
Reviews for Fosamax
43%
-15% worse vs. Reclast
30%
-2% worse vs. Reclast
19%
-17% worse vs. Reclast
169 reviews
Have you used Fosamax (alendronate)?
Worth itNot sureNot worth it
Reviews for Actonel
36%
-8% worse vs. Reclast
19%
+9% better vs. Reclast
25%
-11% worse vs. Reclast
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
Reviews for Boniva
31%
-3% worse vs. Reclast
20%
+8% better vs. Reclast
27%
-9% worse vs. Reclast
Have you used Boniva (ibandronate)?
Worth itNot sureNot worth it
Reviews for Prolia
33%
-5% worse vs. Reclast
40%
-12% worse vs. Reclast
27%
-9% worse vs. Reclast
Have you used Prolia (denosumab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Forteo (teriparatide)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Evista (raloxifene)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Miacalcin (calcitonin)?
Worth itNot sureNot worth it
Side effects
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • Joint pain 4%
  • Fever 13%
  • High blood pressure 1%
  • Muscle aches 8%
  • Headache 4%
  • Pain in arms or legs 1%
  • Nausea 4%
  • Influenza-like Illness 6%
More Reclast side effects »
  • Abdominal pain 2%
  • Bone, muscle or joint pain 1%
  • Diarrhea 1%
  • Gas 2%
  • Headache 1%
  • Constipation 1%
  • Ulcer in esophagus 2%
More Fosamax side effects »
  • Infection 1%
  • Back pain 2%
  • Joint pain 2%
  • Stomach pain 2%
  • Traumatic bone fracture 3%
  • High blood pressure 1%
More Actonel side effects »
  • Abdominal pain 8%
  • High blood pressure 6%
  • Joint pain 6%
  • Indigestion 6%
  • Diarrhea 5%
  • Back pain 5%
  • Nausea 5%
  • Constipation 4%
  • Cold 4%
  • Pain in arms or legs 4%
More Boniva side effects »
  • Pain in extremity 1%
  • Hypercholesterolemia 1%
  • Edema peripheral 1%
  • Upper respiratory tract infection 1%
  • Sciatica 1%
More Prolia side effects »
  • Rhinitis 1%
  • Arthralgia 2%
  • Asthenia 2%
  • Nausea 2%
  • Dizziness 3%
  • Headache 1%
  • Any side effect 1%
  • Pharyngitis 1%
More Forteo side effects »
  • Arthralgia 2%
  • Flu Syndrome 3%
  • Any side effect 2%
  • Hot Flashes 4%
  • Bronchitis 1%
More Evista side effects »
  • Stuffy nose 5%
  • Back pain 3%
More calcitonin side effects »
How it works
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
Reclast (zoledronate) is a bisphosphonate. It slows down the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.Fosamax (alendronate) is a bisphosphonate, which inhibits bone breakdown.Actonel (risedronate) is a bisphosphonate. It slows down osteoclasts, which are the cells that break down bone. This results in greater bone mass, and lowers the possibility of fractures.Boniva (ibandronate) is a bisphosphonate. It slows down osteoclasts, the cells that break down bone. This results in greater bone mass and lowers the possibility of fractures.Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.Forteo (Teriparatide) works by stimulating cells that build up and strengthen your bones.Evista (Raloxifene) is a selective estrogen receptor modulator (SERM). It acts like estrogen to make your bones stronger and less likely to break, and also protects breast and uterus tissues from other estrogen effects.Miacalcin (calcitonin) blocks the cells that break down bone. This makes stronger bones and lowers calcium levels in the blood.
Type of medication
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • Injection
  • Pill
  • Effervescent tablet
  • Liquid
  • Pill
  • Pill
  • Injection
  • Injection
  • Injection
  • Pill
  • Nasal spray
  • Injection
Used for
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
Risk factors for serious side effects
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • Oral or dental surgery
  • Cancer
  • Poor oral hygiene
  • Low parathyroid hormone
  • History of thyroid surgery
Detailed Reclast (zoledronate) risks & warnings »
  • Taking anti-inflammatory medicines like ibuprofen, and naproxen
  • History of ulcers or stomach or esophageal conditions
  • Difficulty swallowing
  • Problems sitting or standing for at least 30 minutes
  • Oral or dental surgery
Detailed Fosamax (alendronate) risks & warnings »
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 30 minutes after taking the medicine
  • Oral or dental surgery
  • Cancer
Detailed Actonel (risedronate) risks & warnings »
  • Taking with aspirin or other NSAIDS (nonsteroidal anti-inflammatory drugs)
  • History of ulcers, or other stomach or esophageal problems
  • History of difficulty swallowing
  • Unable to sit upright or stand for 60 minutes after taking the medicine
  • Oral or dental surgery
Detailed Boniva (ibandronate) risks & warnings »
  • Taking steroids
  • Kidney problems
  • Not taking calcium supplements
  • Taking other medicines that can lower calcium blood levels
  • History of hypoparathyroidism (low levels of parathyroid hormone)
Detailed Prolia (denosumab) risks & warnings »
  • Paget's bone disease
  • Young people with open epiphyses
  • Hypercalcemia
  • Hyperparathyroidism
  • History of kidney stones
Detailed Forteo (teriparatide) risks & warnings »
  • History of stroke
  • Heart and blood vessel problems
  • History of mini stroke (TIA)
  • Atrial fibrillation
  • Smoking
Detailed Evista (raloxifene) risks & warnings »
  • Allergy to fish
  • Seizure history
  • Low calcium in blood
  • Age 65 and above
  • History of cancer
Detailed Miacalcin (calcitonin) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Alcohol
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.No alcohol related info.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
No alcohol related info.
Food
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • People on Reclast (zoledronate) have had breakdown of the jawbone. However, it is rare. It is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, before any oral/dental procedure, tell your surgeon that you are taking Reclast (zoledronate).
No food related info.
  • Although rare, breakdown of the jawbone has happened in people taking Actonel (risedronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. If you notice pain or swelling in your jaw, talk to your doctor right away. Also, tell your surgeon that you are taking Actonel (risedronate) prior to any oral/dental procedures.
  • Although rare, breakdown of the jawbone has happened in people taking Boniva (ibandronate). This is more likely to happen if you have oral or dental surgery, or if you have poor oral hygiene. The risk might also increase the longer you take Boniva (ibandronate). If you notice pain or swelling in your jaw, talk to your doctor right away.
No food related info.No food related info.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
No food related info.
Kidneys and liver
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • Reclast (zoledronate) can cause kidney injury, especially in people who already have problems with their kidneys. It is important that you get blood tests done before each dose to measure your kidney function. Reclast (zoledronate) shouldn’t be used in people who have very poor kidney function.
  • It can't be used if you have really poor kidney function.
No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
  • Forteo (Teriparatide) can cause kidney stones, especially if you have high calcium levels in your urine. If kidney stones are suspected, your doctor can measure the amount of calcium in your urine to see if you are at risk. Be careful using this medication if you have a history of kidney stones.
  • Evista (Raloxifene) is processed by the kidney and liver. If you have kidney or liver problems, talk to your doctor because you may need a different dose.
No kidneys and liver related info.
Pain
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • Joint pain and muscle pain are common side effects after the infusion.
  • Fosamax (alendronate) can cause bone and muscle pain. However, this is very rare. Stop taking the medication and talk to your doctor if this happens to you.
  • Fosamax (alendronate) can cause fractures in the legs as a result of little or no force. This is rare. If you notice a new dull or aching pain in your hips or thighs, talk to your doctor right away.
  • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
  • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
  • Can cause skin irritation, joint pain, limb pain, and back pain.
No pain related info.No pain related info.No pain related info.
Upsides and benefits
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • Available in generic.
  • Depending on what you're using it for, you may only need to take it as a one-time dose, or every 1 to 2 years.
  • First choice to treat osteoporosis
  • Lowers your risk of fractures due to osteoporosis.
  • Available generic.
  • Available as daily, weekly, or twice weekly dosing.
  • Comes as a regular tablet, an oral solution, or effervescent tablet.
  • Actonel (risedronate) is one of the first choice medicines to treat osteoporosis.
  • It is available in generic.
  • It is available in tablets that can be taken by mouth once or twice a month, once a week, or once a day.
  • Available in generic.
  • Available in pills that can be taken by mouth once a month.
  • Also available as a shot given into your vein every 3 months.
  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
  • If you're unable to use bisphosphonates or are still having fractures despite being on other medications, Forteo (Teriparatide) can be a good alternative.
  • You can start using Forteo (Teriparatide) as soon as you stop using bisphosphonates.
  • Evista (Raloxifene) doesn’t affect the breast or uterus the same way that estrogen does, so the risk of cancer is much lower.
  • Taking Evista (Raloxifene) with calcium and vitamin D improves spine and hip bone health and lowers the risk of fractures.
  • Lowers total cholesterol and low-density lipoprotein (LDL) cholesterol (the bad cholesterol).
  • Using the nasal spray causes fewer side effects than the injectable version.
  • Can help with bone pain if you've had a recent fracture.
  • Available in generic.
Downsides and risks
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • You have to go to your doctor's office or an infusion center to get each dose by IV infusion.
  • It can't be used if you have really poor kidney function.
  • Joint pain and muscle pain are common side effects after the infusion.
  • Can harm your esophagus if you don't remain upright for 30 minutes after taking it.
  • Not recommended for people who can't sit or stand upright for at least 30 minutes.
  • Can increase the risk of atypical fractures.
  • Can cause bad heartburn or stomach problems.
  • You have to take Actonel (risedronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 30 minutes after you take it, which can be a problem if you have trouble moving.
  • You have to take Boniva (ibandronate) first thing in the morning with a full glass of water.
  • You have to remain upright for at least 60 minutes after you take the medicine, which can be a problem if you have mobility issues.
  • It is only approved to treat and prevent osteoporosis in women who have gone through menopause.
  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
  • Only available as a brand medication, so it can be expensive.
  • You have to inject this every day, so it may not be a good option if you don't like needles.
  • Shouldn't take this longer than 18 to 24 months since it can increase the risk of bone cancers.
  • Can only take Evista (Raloxifene) once you’re in menopause. You can't take it if you're pregnant or breastfeeding.
  • Evista (Raloxifene) isn’t as effective as tamoxifen at lowering the risk of invasive breast cancer.
  • Shouldn’t take it with any other forms of estrogen (pills, patches, or injection).
  • It doesn’t increase bone strength as much as estrogen does and isn’t effective for treating hot flashes.
  • Miacalcin (calcitonin) is not as effective as other medications used to stop bone loss or lower calcium levels.
  • You're at a higher risk for certain cancers while taking Miacalcin (calcitonin).
  • If you're allergic to fish, you might also be allergic to Miacalcin (calcitonin).
Tips from our pharmacists for people taking the medication
ReclastFosamaxActonelBonivaProliaForteoEvistacalcitonin
  • Eat normally and drink at least 2 glasses of liquid before your infusion.
  • You can take acetaminophen (Tylenol) to lower fever and chills from the infusion.
  • Talk to your doctor if you develop swelling, pain, or soreness in your jaw.
  • Call your doctor if you develop pain in your hips, thighs, or legs.
  • If you have to have dental or oral surgery, tell your surgeon that you're taking this medication.
  • Drink plenty of liquids while you're on this medicine.
  • Take first thing in the morning with a full glass of water.
  • Avoid eating or drinking for 30 minutes after taking Fosamax (alendronate).
  • Remain upright for 30 minutes after taking Fosamax (alendronate).
  • Talk to your doctor if you develop pain around jaw, throat, chest, abdomen, hips or thighs.
  • Let your doctor know if you have any major dental procedures coming up. You may need to temporarily stop taking Fosamax (alendronate).
  • Dissolve the effervescent tablet in 4 ounces of plain water. When solution stops fizzing, wait 5 minutes before stirring for 10 seconds and drinking.
  • If you're taking the immediate release medicine, take it first thing when you wake up by swallowing the whole pill with a full glass of water.
  • Remain sitting or standing, and don't take any other medications, vitamins, or supplements for at least 30 minutes after you take Actonel (risedronate).
  • If you forget to take your dose, skip it and take it the following morning.
  • Keep taking your calcium and vitamin D.
  • Talk to your doctor if you have pain with swallowing, pain in your chest or stomach, or new or worsening heartburn.
  • If you develop pain in your jaw, hips, or thighs, call your doctor.
  • Can be taken as a pill or as an injection.
  • Take the pill first thing when you wake up by swallowing the whole pill with a full glass of plain water.
  • Don't eat or drink anything, or take other medicines for at least 60 minutes after you've taken the pill.
  • Stay sitting or standing for at least 60 minutes after you take the pill.
  • If you have pain with swallowing around your chest or stomach, new or worsening heartburn, or any pain around your hips, thighs, or jaw, tell your doctor right away.
  • Take the 150 mg tablet on the same day every month. If you forget to take the 150 mg tablet on your chosen day each month, take it on the next day in the morning.
  • Keep taking your calcium and vitamin D.
  • Remember to get your shot every 6 months. Write it down on your calendar.
  • If your doctor also told you to take calcium and vitamin D, remember to take them as well. They'll work with Prolia (Denosumab) to help protect your bones.
  • Can cause skin irritation, joint pain, limb pain, and back pain.
  • Let your doctor know if you start getting more infections.
  • Let your dentist know that you’re taking Prolia (Denosumab) since it can cause problems in the jaw bone after dental procedures.
  • You should be sitting or lying down when you inject Forteo (Teriparatide) since it can make you dizzy.
  • You should inject Forteo (Teriparatide) under the skin in either your thigh or stomach.
  • Make sure the liquid in the vial of Forteo (Teriparatide) is clear and colorless before you inject it. Don't use it if it looks cloudy, colored, or if you see particles inside.
  • Take 1 tablet daily with or without food about the same time each day. It’s important to read the information you get with your medicine about how to take Evista (Raloxifene).
  • Your doctor may tell you to take calcium and vitamin D with Evista (Raloxifene) to prevent osteoporosis (bone thinning and loss), especially if you don’t get enough in your diet.
  • Regular exercise, cutting back on smoking, and drinking less alcohol can also reduce your risk of bone loss.
  • New, unopened nasal spray bottles should be stored in the refrigerator until you use them. Once they are opened, they should be stored at room temperature for up to 35 days.
  • Allow nasal spray bottle to reach room temperature before use. Prime before first use by spraying in the air 5 times until full spray is produced.
  • Toss spray bottle after 30 doses. It may not feel empty yet, but it won't deliver the correct dose anymore.
  • Follow the directions your doctor or pharmacist tells you so you get the full dose every time.
  • Continue to take your calcium or vitamin D.
  • The nasal spray is only used for weak bones. Forms of the drug that are injected in the skin or muscles are used for other conditions such as high calcium in the blood, Paget's disease, and weak bones.
Learn more
More about ReclastSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Reclast (zoledronate)?
Worth itNot sureNot worth it
More about FosamaxSide effectsReviews & ratingsFDA package insert
Have you used Fosamax (alendronate)?
Worth itNot sureNot worth it
More about ActonelSide effectsReviews & ratingsFDA package insert
Have you used Actonel (risedronate)?
Worth itNot sureNot worth it
More about BonivaSide effectsReviews & ratingsFDA package insert
Have you used Boniva (ibandronate)?
Worth itNot sureNot worth it
More about ProliaSide effectsReviews & ratingsFDA package insert
Have you used Prolia (denosumab)?
Worth itNot sureNot worth it
More about ForteoSide effectsReviews & ratingsFDA package insert
Have you used Forteo (teriparatide)?
Worth itNot sureNot worth it
More about EvistaSide effectsReviews & ratingsFDA package insert
Have you used Evista (raloxifene)?
Worth itNot sureNot worth it
More about calcitoninSide effectsFDA package insert
Have you used Miacalcin (calcitonin)?
Worth itNot sureNot worth it