Prescription onlyLower-cost generic availableClass: Gastrointestinal

Reglan Alternatives

(metoclopramide)

Prescription onlyLower-cost generic availableClass: Gastrointestinal
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Compare Reglan (metoclopramide) to alternatives

These medications are comparable to Reglan (metoclopramide) or used for similar purposes.

Reglan
(metoclopramide)

Thorazine
(chlorpromazine)

Compro
(prochlorperazine)

Phenergan
(promethazine)

Trilafon
(perphenazine)

Marinol
(dronabinol)

Sancuso
(granisetron)

Relieves nausea and vomiting. Reglan (metoclopramide) can stimulate your gut and relieve nausea, but it can only be used for a short period of time due to avoid serious side-effects.Stabilizes your mood. Thorazine (chlorpromazine) has more side effects than other medicines like it. It is most useful during psychotic episodes because it slows you down quickly.Helps you feel less queasy. Compro (Prochlorperazine) can be used to treat severe nausea and vomiting and can be taken orally or rectally, but get ready for a nap.Helps you feel less queasy. Phenergan (Promethazine) is used to treat and prevent nausea and vomiting from surgery, motion sickness, or pregnancy. While it's cheap and available in different forms to make it easier to take, it can make you feel very sleepy, and its side effects mean that children under 2 and adults over 65 shouldn't take it.Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.Coming soon.Coming soon.
Reviews & ratings
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Have you used Reglan (metoclopramide)?
Worth itNot sureNot worth it

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Have you used Thorazine (chlorpromazine)?
Worth itNot sureNot worth it
Reviews for Compro
45%
+5% better vs. Reglan
35%
+15% better vs. Reglan
35%
-48% worse vs. Reglan
Have you used Compro (prochlorperazine)?
Worth itNot sureNot worth it
Reviews for Phenergan
82%
-32% worse vs. Reglan
76%
-26% worse vs. Reglan
5%
-78% worse vs. Reglan
Have you used Phenergan (promethazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it

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Have you used Marinol (dronabinol)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Sancuso (granisetron)?
Worth itNot sureNot worth it
Side effects
ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
  • Restlessness 10%
  • Drowsiness 10%
  • Fatigue 10%
  • Lack of energy 10%
More Reglan side effects »

The chlorpromazine FDA package insert doesn’t have numbers about how common side effects are.

More about chlorpromazine side effects »

The Compro FDA package insert doesn’t have numbers about how common side effects are.

More about Compro side effects »

The Phenergan FDA package insert doesn’t have numbers about how common side effects are.

More about Phenergan side effects »

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »

We haven’t found good data for Marinol side effects.

FDA side effect reports for Marinol »

We haven’t found good data for Sancuso side effects.

FDA side effect reports for Sancuso »
How it works
ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
Reglan (metoclopramide) is stimulates receptors in your gut to promote the normal emptying of food and reduce nausea.Thorazine (chlorpromazine) is a derivative of phenothiazine, which regulates dopamine levels in your brain to improve your mood.Compro (Prochlorperazine) is an antiemetic (anti-nausea medicine). It works by blocking signals in the part of your brain that causes vomiting.Phenergan (Promethazine) is an antihistamine, which helps control allergies. It also seems to block your body's natural reflex for vomiting, which makes it useful as an antiemetic (anti-nausea medicine).Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.Coming soon.Coming soon.
Type of medication
ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
  • Pill
  • Dissolving tablet
  • Liquid
  • Injectable
  • Pill
  • Injection
  • Pill
  • Suppository
  • Pill
  • Liquid
  • Suppository
  • Pill
  • Pill
  • Pill
  • Liquid
  • Patch
Used for
ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
  • Diabetic Gastroparesis
  • AIDS Loss Of Appetite Chemotherapy Induced Nausea And Vomiting Prophylaxis
  • Chemotherapy Induced Nausea And Vomiting
Risk factors for serious side effects
ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
  • Elderly
  • Women
  • Diabetics
  • Depression
  • Younger than 30 years old
Detailed Reglan (metoclopramide) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
  • Asthma
  • COPD
  • Acute respiratory infections
Detailed Thorazine (chlorpromazine) risks & warnings »
  • Over age 65
  • Dementia
  • Taking antipsychotics
  • History of seizures
  • Age over 65
Detailed Compro (prochlorperazine) risks & warnings »
  • Children under 2 years of age
  • History of seizures
  • Age over 65
Detailed Phenergan (promethazine) risks & warnings »
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
    Coming soon.
      Coming soon.
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      Alcohol
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      • Can make you drowsy so don't drink alcohol or drive while on Reglan (metoclopramide).
      • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
      • Don't drink alcohol to avoid intense side effects.
      • Don't drink alcohol to avoid intense side effects.
      • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
      No alcohol related info.No alcohol related info.
      Kidneys and liver
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      • You may need a lower dose if you have kidney problems.
      No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.No kidneys and liver related info.
      Pain
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      No pain related info.No pain related info.
      • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
      • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
      No pain related info.No pain related info.No pain related info.
      Sleep
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      No sleep related info.
      • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
      • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
      • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
      • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
      • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
      • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
      No sleep related info.No sleep related info.
      Weight
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      No weight related info.No weight related info.No weight related info.No weight related info.
      • You're more likely to gain weight.
      No weight related info.No weight related info.
      Upsides and benefits
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      • Especially useful for relieving nausea caused by cancer chemotherapy.
      • Available in an affordable, generic version
      • If tablets are hard for you to swallow, Reglan (metoclopramide) is also available in as an orally disintegrating tablet or liquid form.
      • Acts fast to slow you down during a psychotic episode.
      • Can also be used for nausea or migraines.
      • Safe for use in children as young as 6 months.
      • Comes in a sugar-coated pill for easy administration.
      • Available in generic, so it's cheap.
      • Can be taken by mouth, as a shot, or rectally.
      • Can take anywhere from 10 minutes (by shot) to 60 minutes (rectally) to start working.
      • Available in generic.
      • Available as a syrup or tablet that you can take by mouth, or as a rectal suppository if you're unable to take anything by mouth.
      • Trilafon (perphenazine) can be much cheaper than other medicines.
      • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
      Coming soonComing soon
      Downsides and risks
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      • Use for more than 12 weeks can cause involuntary movements of the eyes, tongue, face, arm, or legs.
      • May take a while to relieve nausea and vomiting caused by delayed gastric emptying.
      • Not a good option if you have Parkinson's disease, history of seizures, or blockage in your gut.
      • You may need a lower dose if you have kidney problems.
      • Has more side effects than other medicines like it.
      • Can affect how your other medicines work.
      • Makes you more sensitive to the sun.
      • Can make you dizzy or lightheaded, especially when injected.
      • Cannot be stopped right away.
      • Can make you really drowsy. Drinking alcohol with it can make the drowsiness even worse.
      • Can't be used by people over 65 because they can be more affected by the side effects.
      • It can make you more likely to get heatstroke.
      • Can make you feel very sleepy, especially if you're taking other drugs that can make you sleepy or if you drink alcohol.
      • Can't be used in children under 2 years of age or if you're over 65 because of increased risk from side effects.
      • Can make your skin more sensitive to the sun.
      • You're more likely to gain weight.
      • You can be more sensitive to temperature changes.
      • You're more likely to catch colds and flu.
      Coming soonComing soon
      Tips from our pharmacists for people taking the medication
      ReglanchlorpromazineComproPhenerganperphenazineMarinolSancuso
      • Can make you drowsy so don't drink alcohol or drive while on Reglan (metoclopramide).
      • Most doctors prescribe Reglan (metoclopramide) 4 times a day, 30 minutes before each meal, and before bed.
      • Stop Reglan (metoclopramide) and contact a doctor immediately if you begin to have unusual, repetitive movements of the eyes, tongue, face, arm, or legs.
      • Other medicines may interfere with how Reglan (metoclopramide) works so be sure to tell your doctor or pharmacist before starting any medicines.
      • Can make you very sleepy so don't drive or do anything that requires concentration until you know how it affects you.
      • Can cause involuntary muscle movements just like other medicines for your mood.
      • Can dry you out and make you more sensitive to the sun.
      • Don't combine with alcohol or narcotics because it can cause you to stop breathing.
      • Cannot be stopped suddenly.
      • Compro comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
      • You'll likely feel very sleepy, sluggish, or less alert after taking Compro. Avoid driving or other tasks that require your focused attention; be safe.
      • Don't drink alcohol to avoid intense side effects.
      • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Compro.
      • Avoid using if you experience seizures (epilepsy).
      • Don't use if you're 65 or older because you're at higher risk for serious side effects.
      • Promethazine comes in different forms. Be clear on which one you were prescribed - swallow tablets orally, unwrap and insert suppositories rectally.
      • Don't give to kids 2 and under.
      • You'll likely feel very sleepy, sluggish, or less alert after taking Promethazine. Avoid driving or other tasks that require your focused attention; be safe.
      • Don't drink alcohol to avoid intense side effects.
      • Taking certain medications for pain, allergies, or mood conditions can worsen the side effects of Promethazine.
      • Avoid using if you experience seizures (epilepsy).
      • Don't use if you're 65 or older because you're at higher risk for serious side effects.
      • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
      • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
      • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
      • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
      • Take Trilafon (perphenazine) with food to avoid stomach upset.
      Coming soonComing soon
      Learn more
      More about ReglanSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Reglan (metoclopramide)?
      Worth itNot sureNot worth it
      More about chlorpromazineSide effectsFDA package insert
      Have you used Thorazine (chlorpromazine)?
      Worth itNot sureNot worth it
      More about ComproSide effectsReviews & ratingsFDA package insert
      Have you used Compro (prochlorperazine)?
      Worth itNot sureNot worth it
      More about PhenerganSide effectsReviews & ratingsFDA package insert
      Have you used Phenergan (promethazine)?
      Worth itNot sureNot worth it
      More about perphenazineSide effectsFDA package insert
      Have you used Trilafon (perphenazine)?
      Worth itNot sureNot worth it
      More about MarinolSide effectsReviews & ratingsFDA package insert
      Have you used Marinol (dronabinol)?
      Worth itNot sureNot worth it
      More about SancusoSide effectsFDA package insert
      Have you used Sancuso (granisetron)?
      Worth itNot sureNot worth it