Prescription onlyLower-cost generic availableClass: Mental health



Prescription onlyLower-cost generic availableClass: Mental health
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Improves mood.

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Our bottom line

Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.

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  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
  • Good option for people who are underweight or frail, because it can help you gain weight.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
People say this drug is:
152 reviews


  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
How it works

Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.

What to expect when you take Remeron (mirtazapine) for Depression

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Side effect rates for Remeron (mirtazapine)

814 From clinical trials of Remeron / Depression
  • Drowsiness
  • Dry mouth
  • Increased appetite
  • Constipation
  • Weight gain
  • Muscle weakness
  • Dizziness
  • Flu syndrome
  • Abnormal dreams
  • Thinking abnormal

Risks and Warnings for Remeron (mirtazapine)

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    • Higher risk if:
    • Age 24 years or younger

    Remeron (Mirtazapine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Remeron (Mirtazapine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Remeron (mirtazapine)

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  • Sleepiness, feeling 25 years older than I am, sexual dsyfunction, so glad to be coming off it.
  • 15mg in morn,15mg at night.occasionally drowsy.anxiety a million times learning to drive again(terrified before)Now over my bad needle phobia .no more night terrors or insomnia.also take Bach rescue remedy as needed helps alot
  • A few sideffects but overcame these within a few weeks - great for anxiety in combo with diazepam/clonazepam. Taking 45mg every night. Sleepiness was only noticeable when I was taking 15mg on the way up to my current dose thankfully :)
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Can increase appetite and weight.
  • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
  • Tons of weight gain and increased appetite. Makes my lows super low and harder to get out of.
  • Not ideal if you dont want to gain weight!
  • Side effects awful weight gain and they suddenly stop working but you still get withdrawal