Prescription onlyLower-cost generic available

Remeron

(Mirtazapine)

  • Pill
  • Dissolving tablet
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Improves mood.

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Prescription onlyLower-cost generic available

Our pharmacists’ bottom line

Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.

Worth it?Is it worth it?
Works well?Does it work?
Hassle?Is it a hassle?
  • Effective at relieving some depression symptoms.
  • Starts to work more quickly than most antidepressants.
  • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
  • Good option for people who are underweight or frail, because it can help you gain weight.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.

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Side effects for Remeron (Mirtazapine)

From clinical trials of Remeron / Depression ( 814)

  • DrowsinessDrowsiness54% for Mirtazapine vs.18% for placebo
  • DrowsinessDrowsiness54% for Mirtazapine vs.18% for placebo
  • Dry mouthDry mouth25% for Mirtazapine vs.15% for placebo
  • Increased appetiteIncreased appetite17% for Mirtazapine vs.2% for placebo
  • Increased appetiteIncreased appetite17% for Mirtazapine vs.2% for placebo
  • ConstipationConstipation13% for Mirtazapine vs.7% for placebo
  • Weight gainWeight gain12% for Mirtazapine vs.2% for placebo
  • Weight gainWeight gain12% for Mirtazapine vs.2% for placebo
  • Muscle weaknessMuscle weakness8% for Mirtazapine vs.5% for placebo
  • DizzinessDizziness7% for Mirtazapine vs.3% for placebo

What to expect when you take Remeron (Mirtazapine) for Depression

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Tips from our pharmacists
  • Makes you sleepy. Take at bedtime.
  • Can increase appetite and weight.
  • Takes 8 to 12 weeks to see full effects on mood.
  • Stop taking slowly to avoid withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.

Risks and Warnings for Remeron (Mirtazapine)

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    • Higher risk if:
    • Age 24 years or younger

    Remeron (Mirtazapine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Report anything concerning to a doctor immediately. Remeron (Mirtazapine) is not approved for use in children younger than age 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Tips from pharmacists and people taking Remeron (Mirtazapine)

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The FDA category for this medication is C. It is advised that you: Weigh risks vs. benefits
Pregnancy
Food
  • Time of dose is important. If taking it for GI, then take it before meals. Taking it at bedtime, kept me up for 3 hours. No kidding!
    Age: 67
    Gender: Woman
    Taken for: Depression and GI
    Duration taken: Two years or more
Sex
  • Sleepiness, feeling 25 years older than I am, sexual dsyfunction, so glad to be coming off it.
    Age: 40
    Gender: Man
    Taken for: Depression
    Duration taken: A year or so
  • Strong antihistamine effects = take a few days off work when you start, because you will sleep nonstop. Not sure if there were sexual side effects, because I was just tired anyway. Don't think it had much effect.
    Age: 29
    Gender: Woman
    Taken for: Depression, Anxiety
    Duration taken: A few months
Sleep
  • Going from panic attacks weekly, around two hours of sleep a night, and high blood pressure, this medicine has been amazing. I sleep great with little anxiety a day and have normal blood pressure. This is just a few of the many changes.
    Age: 17
    Gender: Woman
    Taken for: Depression
  • It was the best sleep of my life. But I also gained 30lbs in 3 months. I am at weight that I never in my life have weighed. Which is all the Remeron side effect. It truly makes me hate taking this medicine.
    Age: 30
    Gender: Woman
    Taken for: Depression
  • Works well getting u off to sleep but found my moods were either super high or massive lows nothing in between
    Age: 37
    Gender: Man
    Taken for: Depression
Weight gain or loss
  • Upsides and downsides from our pharmacists
  • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
  • Good option for people who are underweight or frail, because it can help you gain weight.
  • Tips from our pharmacists
  • Can increase appetite and weight.
  • Risks from our pharmacists
  • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
  • It was the best sleep of my life. But I also gained 30lbs in 3 months. I am at weight that I never in my life have weighed. Which is all the Remeron side effect. It truly makes me hate taking this medicine.
    Age: 30
    Gender: Woman
    Taken for: Depression
  • Side effects awful weight gain and they suddenly stop working but you still get withdrawal
    Age: 32
    Gender: Woman
    Taken for: Depression
  • Remeron is working incredibly for my insomnia and well for my depression. The main side effect I've experienced is weight gain which is ok because I was underweight prior to starting this medication. It hasn't relieved my anxiety much.
    Age: 21
    Gender: Man
    Taken for: Depression