Prescription onlyClass: Autoimmune

Remicade Alternatives

(infliximab)

Prescription onlyClass: Autoimmune
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Compare Remicade (infliximab) to alternatives

These medications are comparable to Remicade (infliximab) or used for similar purposes.

Remicade
(infliximab)

Cimzia
(certolizumab)

Enbrel
(etanercept)

Humira
(adalimumab)

Simponi
(golimumab)

Calms down your immune system. Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.Calms the immune system and prevents joint damage. Cimzia (certolizumab) effectively calms down your immune system, but you have to be comfortable receiving injections.Calms down your immune system to prevent joint damage. Enbrel (etanercept) effectively calms down your immune system, but it puts you at risk of serious infections.Calms down the immune system. Humira (adalimumab) is good for treating many autoimmune conditions, but it can also cause serious side effects.Calms down the immune system. Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.44Remicade
Reviews for Remicade
76%
of people (All ages) say Remicade is worth it
62%
say it works well
15%
say it's a big hassle
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it
Reviews for Enbrel
62%
+14% better vs. Remicade
53%
+9% better vs. Remicade
17%
+2% better vs. Remicade
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it
Reviews for Humira
60%
+16% better vs. Remicade
51%
+11% better vs. Remicade
26%
+11% better vs. Remicade
182 reviews
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Simponi (golimumab)?
Worth itNot sureNot worth it
Side effects
RemicadeCimziaEnbrelHumiraSimponi
  • Upper airway infection 7%
  • Nausea 1%
  • Headache 4%
  • Sinus infection 6%
  • Sore throat 4%
  • Coughinng 4%
  • Abdominal pain 4%
  • Bronchitis 1%
  • Rash 5%
More Remicade side effects »
  • Infections 8%
  • Upper airway infections 7%
  • Urinary tract infections 1%
  • Joint pain 2%
  • Headache 1%
  • High blood pressure 3%
  • Common cold 4%
  • Back pain 3%
  • Fever 1%
  • Sore throat 2%
More Cimzia side effects »
  • Infections 11%
  • Upper airway infections 8%
  • Injection site reactions 26%
  • Non-upper respiratory infections 6%
  • Rash 1%
  • Fever 3%
  • Itchiness 1%
More Enbrel side effects »
  • Upper airway infection 4%
  • Rash 6%
  • Headache 4%
  • Sinus infection 2%
  • Nausea 1%
  • Injection site reactions 7%
  • Urinary tract infection 3%
  • Flu syndrome 1%
  • Stomach pain 3%
  • High cholesterol 2%
More Humira side effects »
  • Common cold 3%
  • Injection site reaction 4%
  • Viral infections (such as influenza and herpes) 2%
  • Increased liver function test (alt) 1%
  • Increased liver function test (ast) 1%
  • High blood pressure 1%
  • Bronchitis 1%
  • Superficial fungal infections 1%
  • Tingling sensation 1%
  • Dizziness 1%
More Simponi side effects »
How it works
RemicadeCimziaEnbrelHumiraSimponi
Remicade (infliximab) blocks a protein in your immune system called TNF (tumor necrosis factor) that causes inflammation.Cimzia (certolizumab) blocks a protein called TNF (tumor necrosis factor) that causes inflammation.Enbrel (etanercept) blocks a protein called TNF (tumor necrosis factor) in the immune system which lowers inflammation, relieves symptoms and prevents disease progression.Humira (adalimumab) is a TNF blocker which stops inflammation.Simponi (golimumab) blocks a protein called TNF (tumor necrosis factor) that revs up the immune system. Blocking TNF lowers inflammation, relieves symptoms and prevents disease progression. Simponi (golimumab) is also known as a biologic DMARD (disease-modifying anti-rheumatic drug) - or just a "biologic" - when used to treat rheumatoid arthritis.
Type of medication
RemicadeCimziaEnbrelHumiraSimponi
Prescription onlyPrescription onlyPrescription onlyPrescription onlyPrescription only
Available as
RemicadeCimziaEnbrelHumiraSimponi
  • Injection
  • Injection
  • Injection
  • Injection
  • Injection
Used for
RemicadeCimziaEnbrelHumiraSimponi
Risk factors for serious side effects
RemicadeCimziaEnbrelHumiraSimponi
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Comorbidities
  • History of malignancy
Detailed Remicade (infliximab) risks & warnings »
  • Taking other immunosuppressant medications such as methotrexate or steroids
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Cimzia (certolizumab)
Detailed Cimzia (certolizumab) risks & warnings »
  • Latex allergy
  • History of heart failure
  • Taking other immunosuppressant drugs
  • Age 65 or older
Detailed Enbrel (etanercept) risks & warnings »
  • Taking other immunosuppressant medications such as Kineret or Orencia
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • Comorbidities
  • Taking other immunosuppressant medications, such as azathiprine or 6-mercaptopurine, at the same time as Humira (adalimumab)
Detailed Humira (adalimumab) risks & warnings »
  • Taking other immunosuppressant drugs
  • Age 65 or older
  • Active, chronic, or recurrent infection
  • History of malignancy
Detailed Simponi (golimumab) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Weight
RemicadeCimziaEnbrelHumiraSimponi
  • Although rare, Remicade (infliximab) can hurt your liver. If you have appetite/weight loss, stomach discomfort, vomiting, or dark urine, talk to your doctor. If you have yellowing of skin/eyes, talk to your doctor right away.
No weight related info.No weight related info.No weight related info.No weight related info.
Upsides and benefits
RemicadeCimziaEnbrelHumiraSimponi
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • People taking Cimzia (certolizumab) for Crohn's disease, rheumatoid arthritis and other autoimmune conditions had greater clinical response compared to people who did not take Cimzia (certolizumab).
  • Compared to some other drugs used to treat autoimmune conditions, Cimzia (certolizumab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
  • You can give yourself Cimzia (certolizumab) on your own at home rather than visiting a clinic or hospital.
  • After the initial dosing, you need to take Cimzia (certolizumab) every 4 weeks.
  • Cimzia (certolizumab) has been on the market for almost 10 years.
  • People taking Enbrel (etanercept) for rheumatoid arthritis showed significant improvement and were able to reduce the dose or stop their other RA medicines.
  • Enbrel (etanercept) can work for you even if other medications didn't help your rheumatoid arthritis.
  • Enbrel (etanercept) is the first biologic approved for moderate to severe rheumatoid arthritis. Since it has been around for a long time, its side effects are well known.
  • Many people have only minor or no side effects.
  • It's available as a pre-filled syringe and SureClick auto-injector pen which some people find more convenient and easier to use.
  • Humira (adalimumab) is effective in reducing symptoms in all of its approved indications.
  • You can give yourself Humira (adalimumab) on your own at home rather than visiting a clinic or hospital.
  • Humira (adalimumab) treats many different autoimmune conditions.
  • Available in a single-use pen (Humira Pen) that may be more convenient and easier for some people to use.
  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
Downsides and risks
RemicadeCimziaEnbrelHumiraSimponi
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
  • Cimzia (certolizumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, or had tuberculosis (TB) in the past.
  • Can in some cases cause bladder infections, rash and respiratory infections (cold or flu)
  • In rare cases, Cimzia (certolizumab) has been associated with cancers in children and adolescents.
  • Can increase your risk of side effects if you have a history of heart failure, nervous system conditions, or hepatitis B.
  • There's no generic available and it can be expensive.
  • Enbrel (etanercept) raises your risk of serious or life-threatening infections, including tuberculosis (TB).
  • Enbrel (etanercept) can increase the risk of lymphoma, leukemia and other cancers.
  • May not be the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Enbrel (etanercept).
  • You could get injection site reactions such as redness, swelling, rash, itching, or bruising.
  • Not first-choice treatment for rheumatoid arthritis.
  • Humira (adalimumab) is an injection and not an oral medication.
  • Humira (adalimumab) is expensive because there's no generic available yet.
  • Humira (adalimumab) lowers your ability to fight infection and in some cases can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
  • You'll need to properly dispose of the needle, syringes, or Pen in a sharps container.
  • Humira (adalimumab) needs to be refrigerated until you use it, so if you're traveling, you'll need to carry it in a cooler with an ice pack.
  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
Tips from our pharmacists for people taking the medication
RemicadeCimziaEnbrelHumiraSimponi
  • Remicade (infliximab) can in some cases cause a serious allergic reaction either immediately or several days after the treatment. Your doctor can give you medicines that will lower this risk.
  • Your doctor will test you for tuberculosis before taking Remicade (infliximab) and regularly during treatment.
  • Remicade (infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms.
  • You should not receive any live vaccines while taking Remicade (infliximab). Tell your doctor that you are taking Remicade (infliximab) before receiving any vaccines.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • Cimzia (certolizumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so.
  • Each time you use Cimzia (certolizumab), it's important to rotate the sites you chose to inject it in. Don't inject Cimzia (certolizumab) into skin that's red, bruised, or irritated.
  • Keep Cimzia (certolizumab) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
  • Cimzia (certolizumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • If you have any signs or new or worsening symptoms such as heart, neurological, or autoimmune conditions, talk to your doctor. Tell your doctor about symptoms such as bruising or bleeding.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container and not in the trash.
  • Enbrel (etanercept) is available as an injection and a SureClick Autoinjector. You and your doctor can discuss which is best for you.
  • Enbrel (etanercept) is a medication that's injected under the skin (subcutaneous). Your doctor can give you your first dose, then let you self-inject it once you learn how to do it correctly.
  • Enbrel (etanercept) lowers your immune system's ability to fight infections including tuberculosis (TB), fungal, viral, and bacterial infections. Your doctor will check for TB and hepatitis B before starting Enbrel (etanercept). Let your doctor know if you come down with a fever, cough, or notice flu-like symptoms before or during treatment.
  • Enbrel (etanercept) can cause redness, rash, swelling, itching, or bruising at the site of injection. Do not inject into skin that's already red, bruised, or irritated. Rotate your injection areas to avoid skin reactions.
  • Keep Enbrel (etanercept) refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it. Enbrel (etanercept) should not be used if kept at room temperature for longer than 14 days.
  • You should not receive certain vaccinations with Enbrel (etanercept). Discuss with your doctor about your vaccine history and whether you need to receive any vaccines before treatment.
  • Humira (adalimumab) is a medication that's injected under the skin. Your doctor can give you your first dose, then you can inject yourself at home once you feel comfortable doing so on your own.
  • Humira (adalimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Humira (adalimumab), it's important to rotate the sites you chose to inject it in. Don't inject Humira (adalimumab) into skin that's red, bruised, or irritated.
  • As with all injection medicines, store securely away from children and throw away used syringes in an FDA-approved sharps disposal container, and not in the trash.
  • Simponi (golimumab) is an immunosuppressant medication that's injected under the skin (subcutaneous) once a month.
  • Simponi (golimumab) lowers your ability to fight infections, so it's important to let your doctor know if you have a fever, cough, or flu-like symptoms.
  • Tell your doctor if you have an allergy to latex since the syringe needle cover has latex in it.
  • Each time you use Simponi (golimumab), it's important to rotate the sites you chose to inject it in (either your abdomen, thigh, or upper arm). Don't inject Simponi (golimumab) into skin that's red, bruised, or irritated.
  • Keep it refrigerated, and let it sit at room temperature for about 30 minutes before injecting yourself. Do not shake the Simponi (golimumab) autoinjector at any time.
  • People taking Simponi (golimumab) should not get live vaccines. Talk to your doctor before receiving any vaccines.
Learn more
More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Remicade (infliximab)?
Worth itNot sureNot worth it
More about CimziaSide effectsReviews & ratingsFDA package insert
Have you used Cimzia (certolizumab)?
Worth itNot sureNot worth it
More about EnbrelSide effectsReviews & ratingsFDA package insert
Have you used Enbrel (etanercept)?
Worth itNot sureNot worth it
More about HumiraSide effectsReviews & ratingsFDA package insert
Have you used Humira (adalimumab)?
Worth itNot sureNot worth it
More about SimponiSide effectsFDA package insert
Have you used Simponi (golimumab)?
Worth itNot sureNot worth it